Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FSTL1

Summary for FSTL1

Gene information	Gene symbol	FSTL1
	Ensembl ID	ENSG00000163430
	Entrez ID	11167
	Gene name	follistatin like 1
	Synonyms	FRP\|FSL1\|OCC-1\|OCC1\|tsc36
	Gene type	protein_coding
	UniProtAcc	Q12841

Top

Dataset with differentially expressed gene: FSTL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.470357	0.00e+00
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.38753	4.20e-45
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.340618	1.16e-24
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.554885	1.05e-39
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.785206	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.575316	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.40567	0.00e+00

Top

Expression of FSTL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to FSTL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating FSTL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FSTL1	hsa-miR-9-5p	97.5663	NM_007085
FSTL1	hsa-miR-7-2-3p	97.4632	NM_007085
FSTL1	hsa-miR-7-1-3p	97.4632	NM_007085
FSTL1	hsa-miR-548f-5p	97.0577	NM_007085
FSTL1	hsa-miR-548aj-5p	97.0577	NM_007085
FSTL1	hsa-miR-548x-5p	97.0577	NM_007085
FSTL1	hsa-miR-548g-5p	97.0577	NM_007085
FSTL1	hsa-miR-1468-3p	96.4709	NM_007085
FSTL1	hsa-miR-548aw	94.1851	NM_007085
FSTL1	hsa-miR-5682	93.8715	NM_007085
FSTL1	hsa-miR-10522-5p	92.5904	NM_007085
FSTL1	hsa-miR-4496	92.0531	NM_007085
FSTL1	hsa-miR-29a-3p	91.4896	NM_007085
FSTL1	hsa-miR-29c-3p	91.4896	NM_007085
FSTL1	hsa-miR-29b-3p	91.4896	NM_007085
FSTL1	hsa-miR-6875-5p	91.1392	NM_007085
FSTL1	hsa-miR-3126-5p	91.1392	NM_007085
FSTL1	hsa-miR-12136	90.6785	NM_007085
FSTL1	hsa-miR-4795-5p	90.4663	NM_007085
FSTL1	hsa-miR-6782-3p	89.2065	NM_007085
FSTL1	hsa-miR-6871-3p	88.5604	NM_007085
FSTL1	hsa-miR-9902	86.8719	NM_007085
FSTL1	hsa-miR-651-3p	86.2103	NM_007085
FSTL1	hsa-miR-10527-5p	85.5524	NM_007085
FSTL1	hsa-miR-12123	84.7033	NM_007085
FSTL1	hsa-miR-5692b	84.4867	NM_007085
FSTL1	hsa-miR-5692c	84.4867	NM_007085
FSTL1	hsa-miR-1275	84.0456	NM_007085
FSTL1	hsa-miR-3166	83.5239	NM_007085
FSTL1	hsa-miR-4709-3p	82.5482	NM_007085
FSTL1	hsa-miR-4506	82.289	NM_007085
FSTL1	hsa-miR-200b-3p	82.2599	NM_007085
FSTL1	hsa-miR-429	82.2599	NM_007085
FSTL1	hsa-miR-200c-3p	82.2599	NM_007085
FSTL1	hsa-miR-3976	81.9378	NM_007085
FSTL1	hsa-miR-4283	81.3701	NM_007085
FSTL1	hsa-miR-548j-3p	80.076	NM_007085
FSTL1	hsa-miR-548am-3p	80.076	NM_007085
FSTL1	hsa-miR-548ae-3p	80.076	NM_007085
FSTL1	hsa-miR-548ah-3p	80.076	NM_007085
FSTL1	hsa-miR-548aq-3p	80.076	NM_007085

Page: 1

Top

Motifs and transcription factors (TFs) regulating FSTL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FSTL1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
FSTL1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
FSTL1	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
FSTL1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
FSTL1	hdpi__ETV4	ETV4 (directAnnotation).
FSTL1	jaspar__MA1122.1	TFDP1 (directAnnotation).
FSTL1	jaspar__MA1509.1	IRF6 (directAnnotation).
FSTL1	transfac_pro__M06359	ZNF562 (directAnnotation).
FSTL1	transfac_public__M00491	PATZ1 (directAnnotation).
FSTL1	transfac_pro__M05770	ZNF77 (directAnnotation).
FSTL1	tfdimers__MD00516	SOX10 (directAnnotation).
FSTL1	metacluster_22.39	NFE2L2 (directAnnotation).
FSTL1	metacluster_110.2	ZNF549 (directAnnotation).
FSTL1	transfac_pro__M06404	ZNF497 (directAnnotation).
FSTL1	jaspar__MA0079.5	SP1 (directAnnotation).
FSTL1	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
FSTL1	transfac_pro__M01253	CNOT3 (directAnnotation).
FSTL1	transfac_pro__M04817	ZBTB33 (directAnnotation).
FSTL1	transfac_pro__M07260	IKZF1 (directAnnotation).
FSTL1	transfac_pro__M01835	KLF4 (directAnnotation).
FSTL1	hocomoco__PATZ1_HUMAN.H11MO.1.C	PATZ1 (directAnnotation).
FSTL1	swissregulon__hs__MTA3	MTA3 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."