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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FRZB

Summary for FRZB

Gene information	Gene symbol	FRZB
	Ensembl ID	ENSG00000162998
	Entrez ID	2487
	Gene name	frizzled related protein
	Synonyms	FRE\|FRITZ\|FRP-3\|FRZB-1\|FRZB-PEN\|FRZB1\|FZRB\|hFIZ\|SFRP3\|SRFP3
	Gene type	protein_coding
	UniProtAcc	Q92765

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Dataset with differentially expressed gene: FRZB

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	-0.810532	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	1.53098	1.23e-24
GSE161195	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	DARA-KRD (daratumumab + carfilzomib + lenalidomide + dexamethasone)	pre	Malignant cells	-0.321842	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	1.69515	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	1.2634	0.00e+00

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Expression of FRZB in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FRZB

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FRZB

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FRZB	hsa-miR-30d-5p	97.8767	NM_001463
FRZB	hsa-miR-30e-5p	97.8767	NM_001463
FRZB	hsa-miR-30c-5p	97.8767	NM_001463
FRZB	hsa-miR-30b-5p	97.8767	NM_001463
FRZB	hsa-miR-30a-5p	97.8767	NM_001463
FRZB	hsa-miR-4795-3p	96.3975	NM_001463
FRZB	hsa-miR-29a-5p	95.9471	NM_001463
FRZB	hsa-miR-3606-5p	94.4036	NM_001463
FRZB	hsa-miR-4760-3p	94.0707	NM_001463
FRZB	hsa-miR-454-3p	93.7053	NM_001463
FRZB	hsa-miR-1264	93.5423	NM_001463
FRZB	hsa-miR-4295	92.5848	NM_001463
FRZB	hsa-miR-301a-3p	92.1679	NM_001463
FRZB	hsa-miR-301b-3p	92.1679	NM_001463
FRZB	hsa-miR-3666	92.1679	NM_001463
FRZB	hsa-miR-130a-3p	92.1679	NM_001463
FRZB	hsa-miR-130b-3p	92.1679	NM_001463
FRZB	hsa-miR-5197-3p	91.6912	NM_001463
FRZB	hsa-miR-4671-3p	89.7692	NM_001463
FRZB	hsa-miR-4664-5p	89.3117	NM_001463
FRZB	hsa-miR-371b-5p	88.248	NM_001463
FRZB	hsa-miR-616-5p	88.248	NM_001463
FRZB	hsa-miR-373-5p	88.248	NM_001463
FRZB	hsa-miR-342-5p	88.0177	NM_001463
FRZB	hsa-miR-6876-5p	87.4454	NM_001463
FRZB	hsa-miR-4476	87.4454	NM_001463
FRZB	hsa-miR-4455	87.2131	NM_001463
FRZB	hsa-miR-659-3p	86.1376	NM_001463
FRZB	hsa-miR-3910	85.7805	NM_001463
FRZB	hsa-miR-548x-5p	84.3966	NM_001463
FRZB	hsa-miR-548f-5p	84.3966	NM_001463
FRZB	hsa-miR-548g-5p	84.3966	NM_001463
FRZB	hsa-miR-548aj-5p	84.3966	NM_001463
FRZB	hsa-miR-629-5p	83.8632	NM_001463
FRZB	hsa-miR-6828-5p	83.2191	NM_001463
FRZB	hsa-miR-1297	82.6104	NM_001463
FRZB	hsa-miR-340-5p	82.4889	NM_001463
FRZB	hsa-miR-3150b-3p	82.0236	NM_001463
FRZB	hsa-miR-4784	82.0236	NM_001463
FRZB	hsa-miR-6839-3p	81.3498	NM_001463
FRZB	hsa-miR-3121-5p	80.0829	NM_001463

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Motifs and transcription factors (TFs) regulating FRZB

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FRZB	transfac_pro__M02082	ISL2 (directAnnotation).
FRZB	transfac_pro__M05538	ZNF536 (inferredBy_Orthology).
FRZB	metacluster_139.7	XBP1 (directAnnotation). XBP1 (inferredBy_Orthology).
FRZB	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
FRZB	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
FRZB	transfac_pro__M05804	ZBTB41 (inferredBy_Orthology).
FRZB	jaspar__MA1125.1	ZNF384 (directAnnotation).
FRZB	taipale_tf_pairs__GCM1_CEBPB_ATRSGGGNNNNTTRCGYAAN_CAP_repr	CEBPB; GCM1 (directAnnotation).
FRZB	transfac_pro__M06766	ZNF835 (directAnnotation).
FRZB	transfac_pro__M06943	PBX3 (directAnnotation).
FRZB	jaspar__MA1963.1	SATB1 (directAnnotation).
FRZB	transfac_pro__M06226	ZNF460 (directAnnotation).
FRZB	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."