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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FRMD4A

Summary for FRMD4A

Gene information	Gene symbol	FRMD4A
	Ensembl ID	ENSG00000151474
	Entrez ID	55691
	Gene name	FERM domain containing 4A
	Synonyms	bA295P9.4\|FLJ10210\|FRMD4\|KIAA1294
	Gene type	protein_coding
	UniProtAcc	Q9P2Q2

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Dataset with differentially expressed gene: FRMD4A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.312846	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.57209	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.325932	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.390507	0.00e+00

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Expression of FRMD4A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FRMD4A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FRMD4A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FRMD4A	hsa-miR-570-3p	93.9188	NM_001318336
FRMD4A	hsa-miR-450b-5p	92.9593	NM_001318336
FRMD4A	hsa-miR-7844-5p	92.8573	NM_001318336
FRMD4A	hsa-miR-6765-3p	91.6004	NM_001318336
FRMD4A	hsa-miR-5006-3p	91.5709	NM_001318336
FRMD4A	hsa-miR-4755-5p	91.5709	NM_001318336
FRMD4A	hsa-miR-19a-5p	91.044	NM_001318336
FRMD4A	hsa-miR-19b-2-5p	91.044	NM_001318336
FRMD4A	hsa-miR-19b-1-5p	91.044	NM_001318336
FRMD4A	hsa-miR-3679-3p	90.853	NM_001318336
FRMD4A	hsa-miR-186-5p	90.1847	NM_001318336
FRMD4A	hsa-miR-302e	89.9189	NM_001318336
FRMD4A	hsa-miR-6878-5p	89.328	NM_001318336
FRMD4A	hsa-miR-3934-5p	88.5205	NM_001318336
FRMD4A	hsa-miR-877-3p	88.194	NM_001318336
FRMD4A	hsa-miR-19a-3p	88.0092	NM_001318336
FRMD4A	hsa-miR-19b-3p	88.0092	NM_001318336
FRMD4A	hsa-miR-502-5p	87.6753	NM_001318336
FRMD4A	hsa-miR-4495	87.3826	NM_001318336
FRMD4A	hsa-miR-7150	87.3356	NM_001318336
FRMD4A	hsa-miR-655-3p	87.2039	NM_001318336
FRMD4A	hsa-miR-374c-5p	87.2039	NM_001318336
FRMD4A	hsa-miR-548az-5p	85.2778	NM_001318336
FRMD4A	hsa-miR-548t-5p	85.2778	NM_001318336
FRMD4A	hsa-miR-302d-3p	84.6524	NM_001318336
FRMD4A	hsa-miR-302a-3p	84.6524	NM_001318336
FRMD4A	hsa-miR-302b-3p	84.6524	NM_001318336
FRMD4A	hsa-miR-302c-3p	84.6524	NM_001318336
FRMD4A	hsa-miR-520d-3p	84.6524	NM_001318336
FRMD4A	hsa-miR-520e-3p	84.6524	NM_001318336
FRMD4A	hsa-miR-372-3p	84.6524	NM_001318336
FRMD4A	hsa-miR-520b-3p	84.6524	NM_001318336
FRMD4A	hsa-miR-520a-3p	84.6524	NM_001318336
FRMD4A	hsa-miR-520c-3p	84.6524	NM_001318336
FRMD4A	hsa-miR-548n	84.4776	NM_001318336
FRMD4A	hsa-miR-373-3p	84.0944	NM_001318336
FRMD4A	hsa-miR-3618	83.4251	NM_001318336
FRMD4A	hsa-miR-493-5p	83.3415	NM_001318336
FRMD4A	hsa-miR-4775	82.4821	NM_001318336
FRMD4A	hsa-miR-3085-3p	82.4801	NM_001318336
FRMD4A	hsa-miR-149-5p	82.0016	NM_001318336
FRMD4A	hsa-miR-887-5p	81.7949	NM_001318336
FRMD4A	hsa-miR-4772-3p	81.7938	NM_001318336
FRMD4A	hsa-miR-4446-5p	81.5776	NM_001318336
FRMD4A	hsa-miR-548m	81.3187	NM_001318336
FRMD4A	hsa-miR-3129-3p	81.1967	NM_001318336
FRMD4A	hsa-miR-5583-5p	81.1967	NM_001318336

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Motifs and transcription factors (TFs) regulating FRMD4A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FRMD4A	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
FRMD4A	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
FRMD4A	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
FRMD4A	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
FRMD4A	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
FRMD4A	jaspar__MA1933.1	SREBF2 (directAnnotation).
FRMD4A	swissregulon__hs__ETV6	ETV6 (directAnnotation).
FRMD4A	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
FRMD4A	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
FRMD4A	swissregulon__hs__ELF2	ELF2 (directAnnotation).
FRMD4A	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
FRMD4A	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
FRMD4A	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
FRMD4A	cisbp__M08198	ELF1 (directAnnotation).
FRMD4A	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
FRMD4A	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
FRMD4A	taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAP	ETV2; TEF (directAnnotation).
FRMD4A	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
FRMD4A	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
FRMD4A	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."