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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FPR3

Summary for FPR3

Gene information	Gene symbol	FPR3
	Ensembl ID	ENSG00000187474
	Entrez ID	2359
	Gene name	formyl peptide receptor 3
	Synonyms	FMLPY\|FPRH1\|FPRL2\|RMLP-R-I
	Gene type	protein_coding
	UniProtAcc	P25089

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Dataset with differentially expressed gene: FPR3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	0.259076	5.65e-13
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.27483	4.37e-24
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	0.376067	6.48e-04

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Expression of FPR3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FPR3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FPR3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FPR3	hsa-miR-4735-5p	91.9657	NM_002030
FPR3	hsa-miR-433-3p	91.7817	NM_002030
FPR3	hsa-miR-3646	90.898	NM_002030
FPR3	hsa-miR-6507-5p	90.8336	NM_002030
FPR3	hsa-miR-4804-3p	89.0132	NM_002030
FPR3	hsa-miR-4774-5p	87.5569	NM_002030
FPR3	hsa-miR-7-2-3p	87.232	NM_002030
FPR3	hsa-miR-7-1-3p	87.232	NM_002030
FPR3	hsa-miR-4470	84.142	NM_002030
FPR3	hsa-miR-374a-5p	83.5106	NM_002030
FPR3	hsa-miR-4781-3p	81.9109	NM_002030
FPR3	hsa-miR-6808-3p	81.0439	NM_002030
FPR3	hsa-miR-4495	80.6485	NM_002030
FPR3	hsa-miR-374b-5p	80.0958	NM_002030

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Motifs and transcription factors (TFs) regulating FPR3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FPR3	metacluster_56.5	HSF1; HSF1; HSF2 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
FPR3	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
FPR3	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
FPR3	transfac_pro__M06342	ZNF329 (inferredBy_Orthology).
FPR3	metacluster_56.4	HSF1; HSF2; HSF2; HSF4 (directAnnotation).
FPR3	metacluster_22.32	NFE2L2 (directAnnotation).
FPR3	transfac_pro__M05612	ZNF189 (directAnnotation).
FPR3	taipale_tf_pairs__POU2F1_DLX2_WTWTGCATANNTAATTA_CAP_repr	DLX2; POU2F1 (directAnnotation).
FPR3	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
FPR3	transfac_pro__M06267	ZNF805 (directAnnotation).
FPR3	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
FPR3	metacluster_22.29	NFE2 (directAnnotation).
FPR3	transfac_pro__M05877	ZNF467 (inferredBy_Orthology).
FPR3	tfdimers__MD00208	IRF1; LTF (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."