Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: FOXP3

Summary for FOXP3

Gene information	Gene symbol	FOXP3
	Ensembl ID	ENSG00000049768
	Entrez ID	50943
	Gene name	forkhead box P3
	Synonyms	AIID\|DIETER\|IPEX\|JM2\|PIDX\|SCURFIN\|XPID
	Gene type	protein_coding
	UniProtAcc	Q9BZS1

Top

Dataset with differentially expressed gene: FOXP3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.568281	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.391178	1.92e-14
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.813185	3.08e-16
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	-0.378244	5.98e-06

Top

Expression of FOXP3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to FOXP3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating FOXP3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FOXP3	hsa-miR-6867-5p	99.6986	NM_001114377
FOXP3	hsa-miR-4649-3p	94.6426	NM_014009
FOXP3	hsa-miR-6818-5p	93.3104	NM_014009
FOXP3	hsa-miR-147a	91.4718	NM_014009
FOXP3	hsa-miR-5572	91.1336	NM_014009
FOXP3	hsa-miR-134-3p	87.2548	NM_014009
FOXP3	hsa-miR-3911	84.9062	NM_014009
FOXP3	hsa-miR-7974	83.6975	NM_014009
FOXP3	hsa-miR-644a	83.5185	NM_014009
FOXP3	hsa-miR-7854-3p	82.7089	NM_014009
FOXP3	hsa-miR-10401-5p	81.6306	NM_014009

Page: 1

Top

Motifs and transcription factors (TFs) regulating FOXP3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FOXP3	metacluster_2.6	IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).
FOXP3	metacluster_32.25	ZNF287 (directAnnotation).
FOXP3	metacluster_130.2	ZNF182; ZNF22; ZNF225; ZNF225; ZNF285; ZNF362; ZNF362; ZNF384; ZNF487; ZNF512; ZNF570; ZNF613 (directAnnotation). ZNF384 (inferredBy_Orthology).
FOXP3	metacluster_22.18	BACH2 (inferredBy_Orthology).
FOXP3	metacluster_130.3	ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
FOXP3	dbtfbs__ZNF610_HEK293_ENCSR691TXI_merged_N1	ZNF610 (directAnnotation).
FOXP3	transfac_pro__M06499	ZNF383 (directAnnotation).
FOXP3	metacluster_22.32	NFE2L2 (directAnnotation).
FOXP3	metacluster_22.13	MAFK (inferredBy_Orthology).
FOXP3	metacluster_22.19	NFE2 (directAnnotation).
FOXP3	transfac_pro__M07448	ZBED1 (directAnnotation).
FOXP3	hdpi__RAB18	RAB18 (directAnnotation).
FOXP3	homer__VVRRAACAATGG_Sox7	SOX7 (inferredBy_Orthology).
FOXP3	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
FOXP3	metacluster_22.20	MAFG (directAnnotation).
FOXP3	transfac_pro__M05942	ZNF700 (directAnnotation).
FOXP3	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
FOXP3	metacluster_22.36	BACH2 (directAnnotation).
FOXP3	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
FOXP3	metacluster_74.19	HNF1A (inferredBy_Orthology).
FOXP3	metacluster_22.37	BACH1 (directAnnotation).
FOXP3	swissregulon__hs__HBP1	HBP1 (directAnnotation).
FOXP3	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
FOXP3	tfdimers__MD00423	ARID3A; PAX4 (directAnnotation).
FOXP3	hocomoco__FOXP1_HUMAN.H11MO.0.A	FOXP1 (directAnnotation).
FOXP3	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
FOXP3	transfac_pro__M06408	ZSCAN30 (directAnnotation).
FOXP3	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
FOXP3	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
FOXP3	transfac_pro__M05939	ZNF471 (directAnnotation).
FOXP3	metacluster_141.4	GLIS2 (directAnnotation).
FOXP3	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
FOXP3	tfdimers__MD00330	up	CD4+ T cells	GSE169246_PacAteTissue	pre

Page: 1

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."