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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FOXA1

Summary for FOXA1

Gene information	Gene symbol	FOXA1
	Ensembl ID	ENSG00000129514
	Entrez ID	3169
	Gene name	forkhead box A1
	Synonyms	HNF3A
	Gene type	protein_coding
	UniProtAcc	P55317

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Dataset with differentially expressed gene: FOXA1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.488748	8.33e-04
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.409999	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.313587	1.03e-16

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Expression of FOXA1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FOXA1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
FOXA1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating FOXA1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FOXA1	hsa-miR-4789-5p	98.9512	NM_004496
FOXA1	hsa-miR-4705	96.1504	NM_004496
FOXA1	hsa-miR-551b-5p	92.8013	NM_004496
FOXA1	hsa-miR-186-5p	91.5653	NM_004496
FOXA1	hsa-miR-4330	89.4581	NM_004496
FOXA1	hsa-miR-4729	88.0526	NM_004496
FOXA1	hsa-miR-3646	86.9324	NM_004496
FOXA1	hsa-miR-4277	86.9116	NM_004496
FOXA1	hsa-miR-6830-3p	86.3329	NM_004496
FOXA1	hsa-miR-5696	85.3019	NM_004496
FOXA1	hsa-miR-4425	85.0969	NM_004496
FOXA1	hsa-miR-6835-3p	83.712	NM_004496
FOXA1	hsa-miR-4666a-3p	83.614	NM_004496
FOXA1	hsa-miR-6826-5p	83.4201	NM_004496
FOXA1	hsa-miR-6833-3p	82.9965	NM_004496
FOXA1	hsa-miR-3133	82.8543	NM_004496
FOXA1	hsa-miR-3613-3p	82.2304	NM_004496
FOXA1	hsa-miR-584-5p	81.308	NM_004496
FOXA1	hsa-miR-892c-5p	80.8248	NM_004496
FOXA1	hsa-miR-511-5p	80.7745	NM_004496
FOXA1	hsa-miR-760	80.013	NM_004496

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Motifs and transcription factors (TFs) regulating FOXA1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FOXA1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FOXA1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
FOXA1	metacluster_7.13	ZFX (directAnnotation).
FOXA1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
FOXA1	cisbp__M00341	PAX6 (directAnnotation).
FOXA1	cisbp__M07938	E2F1 (directAnnotation).
FOXA1	jaspar__MA1105.2	GRHL2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."