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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FNDC3B

Summary for FNDC3B

Gene information	Gene symbol	FNDC3B
	Ensembl ID	ENSG00000075420
	Entrez ID	64778
	Gene name	fibronectin type III domain containing 3B
	Synonyms	DKFZp762K137\|FAD104\|FLJ23399\|PRO4979\|YVTM2421
	Gene type	protein_coding
	UniProtAcc	Q53EP0

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Dataset with differentially expressed gene: FNDC3B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.540338	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.255876	1.59e-19
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Plasma cells	0.406405	1.68e-26
GSE212217	patients	Peripheral blood mononuclear cells	Endometrial cancer	Epigenetic MMRd endometrial carcinoma	Immunotherapy	pembrolizumab	post	Plasma cells	0.45281	4.68e-04
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.351638	1.37e-04
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.658936	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.29228	7.26e-11
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.305717	1.73e-11
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.803041	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.296928	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.406865	6.80e-06

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Expression of FNDC3B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FNDC3B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FNDC3B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FNDC3B	hsa-miR-4282	99.4913	NM_001135095
FNDC3B	hsa-miR-5683	99.3561	NM_001135095
FNDC3B	hsa-miR-548k	99.1183	NM_001135095
FNDC3B	hsa-miR-548av-5p	99.1183	NM_001135095
FNDC3B	hsa-miR-8054	99.1183	NM_001135095
FNDC3B	hsa-miR-190a-3p	99.0058	NM_001135095
FNDC3B	hsa-miR-548aw	98.9403	NM_001135095
FNDC3B	hsa-miR-3613-3p	98.4414	NM_001135095
FNDC3B	hsa-miR-4760-5p	97.2452	NM_001135095
FNDC3B	hsa-miR-8061	97.1327	NM_001135095
FNDC3B	hsa-miR-95-5p	96.8003	NM_001135095
FNDC3B	hsa-miR-548au-3p	96.572	NM_001135095
FNDC3B	hsa-miR-5011-5p	95.9068	NM_001135095
FNDC3B	hsa-miR-182-5p	95.897	NM_001135095
FNDC3B	hsa-miR-570-3p	95.7317	NM_001135095
FNDC3B	hsa-miR-4427	95.5954	NM_001135095
FNDC3B	hsa-miR-1284	95.331	NM_001135095
FNDC3B	hsa-miR-875-5p	95.3174	NM_001135095
FNDC3B	hsa-miR-5692a	95.1745	NM_001135095
FNDC3B	hsa-let-7a-3p	94.9581	NM_001135095
FNDC3B	hsa-let-7b-3p	94.9581	NM_001135095
FNDC3B	hsa-miR-98-3p	94.9581	NM_001135095
FNDC3B	hsa-let-7f-1-3p	94.9581	NM_001135095
FNDC3B	hsa-miR-4705	94.8448	NM_001135095
FNDC3B	hsa-miR-4262	94.714	NM_001135095
FNDC3B	hsa-miR-4678	94.6403	NM_001135095
FNDC3B	hsa-miR-548g-5p	94.5361	NM_001135095
FNDC3B	hsa-miR-548x-5p	94.5361	NM_001135095
FNDC3B	hsa-miR-548f-5p	94.5361	NM_001135095
FNDC3B	hsa-miR-548aj-5p	94.5361	NM_001135095
FNDC3B	hsa-miR-450b-5p	94.5129	NM_001135095
FNDC3B	hsa-miR-374c-5p	94.3592	NM_001135095
FNDC3B	hsa-miR-655-3p	94.3592	NM_001135095
FNDC3B	hsa-miR-4680-3p	94.1615	NM_001135095
FNDC3B	hsa-miR-1236-5p	93.9858	NM_001135095
FNDC3B	hsa-miR-1277-5p	93.8023	NM_001135095
FNDC3B	hsa-miR-10523-5p	93.7971	NM_001135095
FNDC3B	hsa-miR-548c-3p	93.4388	NM_001135095
FNDC3B	hsa-miR-610	93.405	NM_001135095
FNDC3B	hsa-miR-181d-5p	93.3753	NM_001135095
FNDC3B	hsa-miR-181b-5p	93.3753	NM_001135095
FNDC3B	hsa-miR-181a-5p	93.3753	NM_001135095
FNDC3B	hsa-miR-181c-5p	93.3753	NM_001135095
FNDC3B	hsa-miR-551b-5p	93.2311	NM_001135095
FNDC3B	hsa-miR-4797-5p	93.1883	NM_001135095
FNDC3B	hsa-miR-548l	92.9446	NM_001135095
FNDC3B	hsa-miR-1468-3p	92.9031	NM_001135095
FNDC3B	hsa-miR-5004-5p	92.8958	NM_001135095
FNDC3B	hsa-miR-4770	92.8096	NM_001135095
FNDC3B	hsa-miR-6088	92.8096	NM_001135095

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Motifs and transcription factors (TFs) regulating FNDC3B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FNDC3B	metacluster_7.13	ZFX (directAnnotation).
FNDC3B	cisbp__M01863	ZNF711 (inferredBy_Orthology).
FNDC3B	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
FNDC3B	metacluster_151.2	ZNF23 (directAnnotation).
FNDC3B	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
FNDC3B	transfac_pro__M05479	ZNF580 (directAnnotation).
FNDC3B	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
FNDC3B	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
FNDC3B	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
FNDC3B	metacluster_182.10	ZFX (directAnnotation).
FNDC3B	transfac_pro__M05628	ZNF735 (directAnnotation).
FNDC3B	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
FNDC3B	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FNDC3B	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
FNDC3B	jaspar__MA0079.5	SP1 (directAnnotation).
FNDC3B	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
FNDC3B	transfac_pro__M06035	ZNF749 (directAnnotation).
FNDC3B	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
FNDC3B	jaspar__MA1596.1	ZNF460 (directAnnotation).
FNDC3B	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
FNDC3B	metacluster_35.7	HINFP (inferredBy_Orthology).
FNDC3B	metacluster_98.1	ZNF524 (directAnnotation).
FNDC3B	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
FNDC3B	metacluster_155.13	ZNF135 (directAnnotation).
FNDC3B	jaspar__MA0039.4	KLF4 (directAnnotation).
FNDC3B	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
FNDC3B	taipale_cyt_meth__KLF3_NRCCGCAGCCCN_FL_meth_repr	KLF3 (directAnnotation).
FNDC3B	tfdimers__MD00457	SREBF1; SREBF2; ZNF354C (directAnnotation).
FNDC3B	transfac_pro__M04595	SALL2 (directAnnotation).
FNDC3B	jaspar__MA1117.1	RELB (directAnnotation).
FNDC3B	metacluster_135.11	NR2C2 (directAnnotation).
FNDC3B	tfdimers__MD00038	TFAP2C (directAnnotation).
FNDC3B	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
FNDC3B	cisbp__M00968	MTF2 (directAnnotation).
FNDC3B	metacluster_160.20	JUND; PRDM15 (directAnnotation).
FNDC3B	cisbp__M00341	PAX6 (directAnnotation).
FNDC3B	metacluster_198.3	ZFP64 (directAnnotation).
FNDC3B	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
FNDC3B	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
FNDC3B	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
FNDC3B	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
FNDC3B	cisbp__M00788	ZFY (inferredBy_Orthology).
FNDC3B	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
FNDC3B	metacluster_175.1	ZNF283 (directAnnotation).
FNDC3B	hdpi__ZNF304	ZNF304 (directAnnotation).
FNDC3B	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
FNDC3B	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
FNDC3B	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
FNDC3B	transfac_pro__M01199	TRIM28 (directAnnotation).
FNDC3B	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."