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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FLVCR2

Summary for FLVCR2

Gene information	Gene symbol	FLVCR2
	Ensembl ID	ENSG00000119686
	Entrez ID	55640
	Gene name	FLVCR heme transporter 2
	Synonyms	C14orf58\|CCT\|FLJ20371\|MFSD7C\|SLC49A2
	Gene type	protein_coding
	UniProtAcc	Q9UPI3

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Dataset with differentially expressed gene: FLVCR2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.311643	2.59e-24

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Expression of FLVCR2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FLVCR2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FLVCR2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FLVCR2	hsa-miR-8485	98.5843	NM_017791
FLVCR2	hsa-miR-4753-3p	94.0531	NM_017791
FLVCR2	hsa-miR-30c-5p	93.5977	NM_001195283
FLVCR2	hsa-miR-30d-5p	93.5977	NM_001195283
FLVCR2	hsa-miR-30e-5p	93.5977	NM_001195283
FLVCR2	hsa-miR-30b-5p	93.5977	NM_001195283
FLVCR2	hsa-miR-30a-5p	93.5977	NM_001195283
FLVCR2	hsa-miR-642a-5p	91.1524	NM_001195283
FLVCR2	hsa-miR-4319	90.1349	NM_001195283
FLVCR2	hsa-miR-125a-5p	87.8871	NM_001195283
FLVCR2	hsa-miR-125b-5p	87.8871	NM_001195283
FLVCR2	hsa-miR-6811-5p	85.5603	NM_017791
FLVCR2	hsa-miR-6511b-5p	85.5603	NM_017791
FLVCR2	hsa-miR-4659b-3p	85.0365	NM_017791
FLVCR2	hsa-miR-4659a-3p	85.0365	NM_017791
FLVCR2	hsa-miR-4719	84.4755	NM_017791
FLVCR2	hsa-miR-4667-3p	83.3853	NM_001195283
FLVCR2	hsa-miR-4307	81.4479	NM_017791
FLVCR2	hsa-miR-766-5p	81.05	NM_017791
FLVCR2	hsa-miR-571	80.2282	NM_017791
FLVCR2	hsa-miR-4496	80.1984	NM_017791
FLVCR2	hsa-miR-12124	80.1984	NM_017791

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Motifs and transcription factors (TFs) regulating FLVCR2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FLVCR2	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
FLVCR2	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."