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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FLVCR1

Summary for FLVCR1

Gene information	Gene symbol	FLVCR1
	Ensembl ID	ENSG00000162769
	Entrez ID	28982
	Gene name	FLVCR heme transporter 1
	Synonyms	AXPC1\|FLVCR\|MFSD7B\|PCA\|SLC49A1
	Gene type	protein_coding
	UniProtAcc	Q9Y5Y0

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Dataset with differentially expressed gene: FLVCR1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.383071	3.09e-18

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Expression of FLVCR1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FLVCR1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FLVCR1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FLVCR1	hsa-miR-6867-5p	96.244	NM_014053
FLVCR1	hsa-miR-12136	96.0823	NM_014053
FLVCR1	hsa-miR-377-3p	95.5615	NM_014053
FLVCR1	hsa-miR-4803	95.2311	NM_014053
FLVCR1	hsa-miR-1468-3p	95.0009	NM_014053
FLVCR1	hsa-miR-1297	94.5414	NM_014053
FLVCR1	hsa-miR-758-3p	93.8653	NM_014053
FLVCR1	hsa-miR-26a-5p	91.8359	NM_014053
FLVCR1	hsa-miR-26b-5p	91.8359	NM_014053
FLVCR1	hsa-miR-10527-5p	91.4642	NM_014053
FLVCR1	hsa-miR-30d-5p	90.3182	NM_014053
FLVCR1	hsa-miR-30b-5p	90.3182	NM_014053
FLVCR1	hsa-miR-30a-5p	90.3182	NM_014053
FLVCR1	hsa-miR-30c-5p	90.3182	NM_014053
FLVCR1	hsa-miR-30e-5p	90.3182	NM_014053
FLVCR1	hsa-miR-590-3p	89.4414	NM_014053
FLVCR1	hsa-miR-586	89.2006	NM_014053
FLVCR1	hsa-miR-4465	88.1639	NM_014053
FLVCR1	hsa-miR-498-5p	86.0217	NM_014053
FLVCR1	hsa-miR-4672	85.4129	NM_014053
FLVCR1	hsa-miR-4755-5p	84.0024	NM_014053
FLVCR1	hsa-miR-5006-3p	84.0024	NM_014053
FLVCR1	hsa-miR-26b-3p	83.7241	NM_014053
FLVCR1	hsa-miR-1283	82.5957	NM_014053
FLVCR1	hsa-miR-4799-5p	82.4131	NM_014053
FLVCR1	hsa-miR-6741-5p	82.3948	NM_014053
FLVCR1	hsa-miR-1277-5p	81.9129	NM_014053
FLVCR1	hsa-miR-3941	81.3703	NM_014053
FLVCR1	hsa-miR-3148	81.0223	NM_014053

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Motifs and transcription factors (TFs) regulating FLVCR1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FLVCR1	metacluster_135.11	NR2C2 (directAnnotation).
FLVCR1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FLVCR1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
FLVCR1	cisbp__M00968	MTF2 (directAnnotation).
FLVCR1	cisbp__M00341	PAX6 (directAnnotation).
FLVCR1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."