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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FLT3LG

Summary for FLT3LG

Gene information	Gene symbol	FLT3LG
	Ensembl ID	ENSG00000090554
	Entrez ID	2323
	Gene name	fms related receptor tyrosine kinase 3 ligand
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: FLT3LG

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	0.273211	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD8+ T cells	-0.291817	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	0.255574	0.00e+00

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Expression of FLT3LG in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FLT3LG

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
FLT3LG	CD8+ T cells	CPI-SS0D97E07F8	FLT3LG_FLT3	FLT3LG	FLT3	False	CD8+ T cells	Progenitors	GSE197268_Axi-cel	post	resistant
FLT3LG	CD8+ T cells	CPI-SS0D97E07F8	FLT3LG_FLT3	FLT3LG	FLT3	False	CD8+ T cells	cDCs	GSE197268_Axi-cel	post	resistant
FLT3LG	CD8+ T cells	CPI-SS0D97E07F8	FLT3LG_FLT3	FLT3LG	FLT3	False	CD8+ T cells	pDCs	GSE197268_Axi-cel	post	resistant
FLT3LG	CD8+ T cells	CPI-SS0D97E07F8	FLT3LG_FLT3	FLT3LG	FLT3	False	CD8+ T cells	B cells	GSE197268_Axi-cel	post	sensitive
FLT3LG	CD8+ T cells	CPI-SS0D97E07F8	FLT3LG_FLT3	FLT3LG	FLT3	False	CD8+ T cells	Progenitors	GSE197268_Axi-cel	post	sensitive
FLT3LG	CD8+ T cells	CPI-SS0D97E07F8	FLT3LG_FLT3	FLT3LG	FLT3	False	CD8+ T cells	cDCs	GSE197268_Axi-cel	post	sensitive
FLT3LG	CD8+ T cells	CPI-SS0D97E07F8	FLT3LG_FLT3	FLT3LG	FLT3	False	CD8+ T cells	pDCs	GSE197268_Axi-cel	post	sensitive
FLT3LG	CD8+ T cells	CPI-SS0D97E07F8	FLT3LG_FLT3	FLT3LG	FLT3	False	CD8+ T cells	Malignant cells	GSE199333	post	resistant
FLT3LG	CD8+ T cells	CPI-SS0D97E07F8	FLT3LG_FLT3	FLT3LG	FLT3	False	CD8+ T cells	Malignant cells	GSE199333	post	sensitive

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FLT3LG

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FLT3LG	hsa-miR-6728-5p	91.7471	NM_001204503
FLT3LG	hsa-let-7g-3p	85.0012	NM_001204502
FLT3LG	hsa-let-7a-2-3p	85.0012	NM_001204502
FLT3LG	hsa-miR-6836-3p	84.7643	NM_001204502
FLT3LG	hsa-miR-5187-5p	82.387	NM_001204503
FLT3LG	hsa-miR-4666a-3p	80.8926	NM_001204502
FLT3LG	hsa-let-7b-3p	80.736	NM_001204502
FLT3LG	hsa-let-7f-1-3p	80.736	NM_001204502
FLT3LG	hsa-let-7a-3p	80.736	NM_001204502
FLT3LG	hsa-miR-98-3p	80.736	NM_001204502

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Motifs and transcription factors (TFs) regulating FLT3LG

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FLT3LG	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
FLT3LG	transfac_pro__M06733	RBAK (directAnnotation).
FLT3LG	metacluster_111.5	E4F1; E4F1 (directAnnotation).
FLT3LG	transfac_pro__M06317	ZNF829 (directAnnotation).
FLT3LG	cisbp__M04023	CREB1 (directAnnotation).
FLT3LG	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
FLT3LG	tfdimers__MD00053	TCF3; ZNF354C (directAnnotation).
FLT3LG	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
FLT3LG	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
FLT3LG	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
FLT3LG	metacluster_2.6	IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).
FLT3LG	transfac_pro__M12441	ZNF281 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."