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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: FLI1

Summary for FLI1

Gene information	Gene symbol	FLI1
	Ensembl ID	ENSG00000151702
	Entrez ID	2313
	Gene name	Fli-1 proto-oncogene, ETS transcription factor
	Synonyms	EWSR2\|FLI-1\|SIC-1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: FLI1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.275134	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.255516	2.75e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.325179	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.355741	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.396709	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.477223	6.52e-36
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.250693	5.79e-17
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.256341	0.00e+00

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Expression of FLI1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FLI1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FLI1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FLI1	hsa-miR-5195-3p	99.7068	NM_001167681
FLI1	hsa-miR-145-5p	99.7068	NM_001167681
FLI1	hsa-miR-190a-3p	99.038	NM_001167681
FLI1	hsa-miR-181a-2-3p	98.7931	NM_001167681
FLI1	hsa-miR-5011-5p	98.1628	NM_001167681
FLI1	hsa-miR-548z	94.518	NM_001167681
FLI1	hsa-miR-548bb-3p	94.518	NM_001167681
FLI1	hsa-miR-548d-3p	94.518	NM_001167681
FLI1	hsa-miR-548ac	94.518	NM_001167681
FLI1	hsa-miR-548h-3p	94.518	NM_001167681
FLI1	hsa-miR-193b-3p	94.4523	NM_001167681
FLI1	hsa-miR-193a-3p	94.4523	NM_001167681
FLI1	hsa-let-7a-2-3p	94.4449	NM_001167681
FLI1	hsa-let-7g-3p	94.4449	NM_001167681
FLI1	hsa-miR-3133	94.1121	NM_001167681
FLI1	hsa-miR-580-3p	92.3989	NM_001167681
FLI1	hsa-miR-194-5p	91.4841	NM_001167681
FLI1	hsa-miR-576-5p	91.1376	NM_001167681
FLI1	hsa-miR-4493	90.5051	NM_001167681
FLI1	hsa-miR-1185-1-3p	90.2319	NM_001167681
FLI1	hsa-miR-1185-2-3p	90.2319	NM_001167681
FLI1	hsa-let-7f-2-3p	90.2319	NM_001167681
FLI1	hsa-miR-1237-3p	89.4151	NM_001167681
FLI1	hsa-miR-6875-3p	89.4064	NM_001167681
FLI1	hsa-miR-548aj-3p	88.5151	NM_001167681
FLI1	hsa-miR-548x-3p	88.5151	NM_001167681
FLI1	hsa-miR-5696	88.3508	NM_001167681
FLI1	hsa-miR-215-3p	86.954	NM_001167681
FLI1	hsa-miR-605-5p	86.7537	NM_001167681
FLI1	hsa-miR-297	86.102	NM_001167681
FLI1	hsa-miR-548ae-3p	85.3721	NM_001167681
FLI1	hsa-miR-548am-3p	85.3721	NM_001167681
FLI1	hsa-miR-548j-3p	85.3721	NM_001167681
FLI1	hsa-miR-548ah-3p	85.3721	NM_001167681
FLI1	hsa-miR-548aq-3p	85.3721	NM_001167681
FLI1	hsa-miR-4712-5p	84.479	NM_001167681
FLI1	hsa-miR-770-5p	84.479	NM_001167681
FLI1	hsa-miR-200c-3p	84.3694	NM_001167681
FLI1	hsa-miR-200b-3p	84.3694	NM_001167681
FLI1	hsa-miR-429	84.3694	NM_001167681
FLI1	hsa-miR-4753-5p	83.8351	NM_001167681
FLI1	hsa-miR-4517	83.6484	NM_001167681
FLI1	hsa-miR-138-2-3p	83.5961	NM_001167681
FLI1	hsa-miR-613	83.4187	NM_001167681
FLI1	hsa-miR-206	83.4187	NM_001167681
FLI1	hsa-miR-1-3p	83.4187	NM_001167681
FLI1	hsa-miR-548ar-3p	83.2626	NM_001167681
FLI1	hsa-let-7c-3p	82.5881	NM_001167681
FLI1	hsa-miR-548f-3p	81.9209	NM_001167681
FLI1	hsa-miR-548a-3p	81.9209	NM_001167681

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Motifs and transcription factors (TFs) regulating FLI1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FLI1	transfac_public__M00024	E2F1 (directAnnotation).
FLI1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
FLI1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
FLI1	transfac_pro__M04950	EGR1 (directAnnotation).
FLI1	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
FLI1	transfac_pro__M00652	NRF1 (directAnnotation).
FLI1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
FLI1	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
FLI1	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
FLI1	metacluster_22.29	NFE2 (directAnnotation).
FLI1	tfdimers__MD00339	HMGA1; HMGA2; TFAP2C (directAnnotation).
FLI1	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
FLI1	metacluster_22.13	MAFK (inferredBy_Orthology).
FLI1	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
FLI1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
FLI1	transfac_pro__M05721	ZNF235 (directAnnotation).
FLI1	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
FLI1	transfac_public__M00040	ATF2 (directAnnotation).
FLI1	metacluster_141.4	GLIS2 (directAnnotation).
FLI1	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
FLI1	hdpi__TP73	TP73 (directAnnotation).
FLI1	cisbp__M08198	ELF1 (directAnnotation).
FLI1	transfac_pro__M06032	ZNF727 (directAnnotation).
FLI1	hdpi__NRL	NRL (directAnnotation).
FLI1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
FLI1	cisbp__M00968	MTF2 (directAnnotation).
FLI1	transfac_pro__M07310	SP5 (directAnnotation).
FLI1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
FLI1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
FLI1	metacluster_155.11	SPZ1 (directAnnotation).
FLI1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
FLI1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
FLI1	hdpi__HTATIP2	HTATIP2 (directAnnotation).
FLI1	hdpi__HIP2	UBE2K (directAnnotation).
FLI1	hdpi__ZNF304	ZNF304 (directAnnotation).
FLI1	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
FLI1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
FLI1	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
FLI1	transfac_pro__M02089	E2F3 (directAnnotation).
FLI1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FLI1	cisbp__M07938	E2F1 (directAnnotation).
FLI1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
FLI1	transfac_pro__M04817	ZBTB33 (directAnnotation).
FLI1	tfdimers__MD00483	ZBTB14 (directAnnotation).
FLI1	transfac_pro__M07317	CTBP1 (directAnnotation).
FLI1	transfac_pro__M12697	ZNF142 (directAnnotation).
FLI1	transfac_pro__M00716	ZBTB14 (directAnnotation).
FLI1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
FLI1	transfac_pro__M03806	ZBTB7C (directAnnotation).
FLI1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
FLI1	metacluster_191.3	up	Malignant cells	GSE153697	NA
FLI1	metacluster_166.4	up	Malignant cells	GSE153697	NA
FLI1	hdpi__FLI1	up	Malignant cells	GSE153697	NA
FLI1	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	up	Malignant cells	GSE153697	NA
FLI1	hdpi__FLI1	down	Malignant cells	GSE161801_PI	pre
FLI1	hdpi__FLI1	up	B cells	GSE169246_PacBlood	pre
FLI1	taipale_tf_pairs__FLI1_CEBPD_RNCGGANNTTGCGCAAN_CAP	up	B cells	GSE169246_PacBlood	pre
FLI1	hdpi__FLI1	up	CD4+ T cells	GSE169246_PacBlood	pre
FLI1	taipale_tf_pairs__FLI1_DLX2_ACCGGAARTNNNYAATTA_HT	up	CD4+ T cells	GSE169246_PacBlood	pre
FLI1	taipale_tf_pairs__FLI1_CEBPD_RNCGGANNTTGCGCAAN_CAP	up	CD4+ T cells	GSE169246_PacBlood	pre
FLI1	metacluster_166.4	up	CD4+ T cells	GSE169246_PacBlood	pre
FLI1	hdpi__FLI1	up	CD8+ T cells	GSE169246_PacBlood	pre
FLI1	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	up	CD8+ T cells	GSE169246_PacBlood	pre
FLI1	metacluster_166.4	up	CD8+ T cells	GSE169246_PacBlood	pre
FLI1	metacluster_191.3	up	CD8+ T cells	GSE169246_PacBlood	pre
FLI1	taipale_tf_pairs__FLI1_DLX2_ACCGGAARTNNNYAATTA_HT	up	CD8+ T cells	GSE169246_PacBlood	pre
FLI1	hdpi__FLI1	up	cDCs	GSE169246_PacBlood	pre
FLI1	taipale_tf_pairs__FLI1_DLX2_ACCGGAARTNNNYAATTA_HT	up	cDCs	GSE169246_PacBlood	pre
FLI1	metacluster_191.3	up	cDCs	GSE169246_PacBlood	pre
FLI1	metacluster_166.4	up	cDCs	GSE169246_PacBlood	pre
FLI1	hdpi__FLI1	up	NK cells	GSE169246_PacBlood	pre
FLI1	metacluster_166.4	up	NK cells	GSE169246_PacBlood	pre
FLI1	metacluster_191.3	up	NK cells	GSE169246_PacBlood	pre
FLI1	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	up	NK cells	GSE169246_PacBlood	pre
FLI1	metacluster_35.2	up	NK cells	GSE169246_PacBlood	pre
FLI1	hdpi__FLI1	up	Malignant cells	GSE199333	post
FLI1	metacluster_191.3	up	Malignant cells	GSE199333	post
FLI1	metacluster_166.4	up	Malignant cells	GSE199333	post

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."