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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: FKBP1A

Summary for FKBP1A

Gene information	Gene symbol	FKBP1A
	Ensembl ID	ENSG00000088832
	Entrez ID	2280
	Gene name	FKBP prolyl isomerase 1A
	Synonyms	FKBP-12\|FKBP1\|FKBP12\|FKBP12C\|PKC12\|PPIASE
	Gene type	protein_coding
	UniProtAcc	P62942

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Dataset with differentially expressed gene: FKBP1A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.04745	1.82e-12
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.271422	1.71e-13
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.47402	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.859391	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.607955	6.73e-21
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.257358	1.20e-37
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.299785	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	-0.267987	1.00e-10
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	-0.347636	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.336872	1.19e-25
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	cDCs	0.338661	3.09e-03
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	-0.344644	3.26e-15
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.435538	8.82e-26
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.444636	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.357671	2.88e-32
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.328355	9.97e-16
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Mono/Macro	-0.268077	2.73e-15
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.330756	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.279453	8.45e-27
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.362881	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.317792	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.304053	1.20e-24
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.490854	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.253451	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.37423	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.314284	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-1.28554	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.405392	0.00e+00

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Expression of FKBP1A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FKBP1A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FKBP1A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FKBP1A	hsa-miR-4738-3p	95.4588	NM_001199786
FKBP1A	hsa-miR-6802-3p	94.0053	NM_001199786
FKBP1A	hsa-miR-6756-5p	93.6947	NM_001199786
FKBP1A	hsa-miR-3978	92.4903	NM_001199786
FKBP1A	hsa-miR-1250-3p	92.4585	NM_001199786
FKBP1A	hsa-miR-1277-5p	92.3201	NM_001199786
FKBP1A	hsa-miR-6766-5p	91.0797	NM_001199786
FKBP1A	hsa-miR-141-3p	89.9948	NM_054014
FKBP1A	hsa-miR-200a-3p	89.9948	NM_054014
FKBP1A	hsa-miR-4262	89.8832	NM_000801
FKBP1A	hsa-miR-2467-3p	89.7232	NM_000801
FKBP1A	hsa-miR-577	89.3354	NM_001199786
FKBP1A	hsa-miR-570-3p	89.1725	NM_001199786
FKBP1A	hsa-miR-5011-5p	88.7569	NM_001199786
FKBP1A	hsa-miR-3714	88.1814	NM_000801
FKBP1A	hsa-miR-1284	87.9768	NM_001199786
FKBP1A	hsa-miR-3158-3p	87.8517	NM_001199786
FKBP1A	hsa-miR-4796-5p	87.7098	NM_001199786
FKBP1A	hsa-miR-6835-3p	87.6005	NM_001199786
FKBP1A	hsa-miR-548z	87.0273	NM_000801
FKBP1A	hsa-miR-548h-3p	87.0273	NM_000801
FKBP1A	hsa-miR-548d-3p	87.0273	NM_000801
FKBP1A	hsa-miR-548bb-3p	87.0273	NM_000801
FKBP1A	hsa-miR-548ac	87.0273	NM_000801
FKBP1A	hsa-miR-181d-5p	86.9495	NM_000801
FKBP1A	hsa-miR-338-3p	86.395	NM_000801
FKBP1A	hsa-miR-4328	85.6354	NM_054014
FKBP1A	hsa-miR-5582-3p	84.9866	NM_000801
FKBP1A	hsa-miR-561-5p	84.7061	NM_001199786
FKBP1A	hsa-miR-6880-5p	84.0482	NM_001199786
FKBP1A	hsa-miR-6754-3p	83.9305	NM_000801
FKBP1A	hsa-miR-92b-3p	83.8145	NM_001199786
FKBP1A	hsa-miR-92a-3p	83.8145	NM_001199786
FKBP1A	hsa-miR-32-5p	83.8145	NM_001199786
FKBP1A	hsa-miR-3065-3p	83.7228	NM_000801
FKBP1A	hsa-miR-363-3p	83.6828	NM_001199786
FKBP1A	hsa-miR-367-3p	83.6828	NM_001199786
FKBP1A	hsa-miR-25-3p	83.6828	NM_001199786
FKBP1A	hsa-miR-181b-5p	83.5161	NM_000801
FKBP1A	hsa-miR-181c-5p	83.5161	NM_000801
FKBP1A	hsa-miR-181a-5p	83.5161	NM_000801
FKBP1A	hsa-miR-6780b-5p	83.4489	NM_001199786
FKBP1A	hsa-miR-4725-3p	83.4489	NM_001199786
FKBP1A	hsa-miR-4271	82.485	NM_001199786
FKBP1A	hsa-miR-4717-5p	82.4654	NM_001199786
FKBP1A	hsa-miR-3662	82.2604	NM_001199786
FKBP1A	hsa-miR-6511b-3p	82.2117	NM_000801
FKBP1A	hsa-miR-6511a-3p	82.2117	NM_000801
FKBP1A	hsa-miR-183-5p	81.9996	NM_001199786
FKBP1A	hsa-miR-655-5p	81.7901	NM_000801

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Motifs and transcription factors (TFs) regulating FKBP1A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FKBP1A	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
FKBP1A	jaspar__MA1483.2	ELF2 (directAnnotation).
FKBP1A	hdpi__ETV4	ETV4 (directAnnotation).
FKBP1A	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FKBP1A	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
FKBP1A	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
FKBP1A	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
FKBP1A	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
FKBP1A	cisbp__M08198	ELF1 (directAnnotation).
FKBP1A	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
FKBP1A	swissregulon__hs__ELF2	ELF2 (directAnnotation).
FKBP1A	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
FKBP1A	hdpi__FLI1	FLI1 (directAnnotation).
FKBP1A	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
FKBP1A	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
FKBP1A	cisbp__M02645	ETS1 (directAnnotation).
FKBP1A	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
FKBP1A	metacluster_112.5	HOXA4; PAX3; PAX7; PAX7 (directAnnotation).
FKBP1A	hocomoco__ZN490_HUMAN.H11MO.0.C	ZNF490 (directAnnotation).
FKBP1A	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
FKBP1A	transfac_pro__M01660	GABPA (directAnnotation).
FKBP1A	transfac_pro__M06426	ZNF761 (directAnnotation).
FKBP1A	swissregulon__hs__SPI1	SPI1 (directAnnotation).
FKBP1A	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
FKBP1A	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
FKBP1A	jaspar__MA1933.1	SREBF2 (directAnnotation).
FKBP1A	jaspar__MA1708.1	ETV7 (directAnnotation).
FKBP1A	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
FKBP1A	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
FKBP1A	metacluster_32.28	ZFP28 (directAnnotation).
FKBP1A	metacluster_145.10	ZNF24 (directAnnotation).
FKBP1A	transfac_pro__M05941	ZNF471 (directAnnotation).
FKBP1A	kznf__ZNF182_Imbeault2017_OM_RCADE	ZNF182 (directAnnotation).
FKBP1A	kznf__CTCF_Rhee2011.2_ChIP-exo	CTCF (directAnnotation).
FKBP1A	metacluster_32.24	ZNF287 (directAnnotation).
FKBP1A	tfdimers__MD00404	FOXA1; FOXA2; FOXA3; FOXP3 (directAnnotation).
FKBP1A	transfac_pro__M08803	CREM (directAnnotation).
FKBP1A	taipale_tf_pairs__CEBPG_CREB3L1_NGCCACGCAAYN_CAP_repr	CEBPG; CREB3L1 (directAnnotation).
FKBP1A	transfac_pro__M06919	ZNF652 (directAnnotation).
FKBP1A	transfac_pro__M06270	ZNF468 (directAnnotation).
FKBP1A	transfac_pro__M05702	ZNF20 (directAnnotation).
FKBP1A	taipale_tf_pairs__MGA_EVX1_AGGTGNTAATKWNNNNTN_CAP_repr	EVX1; MGA (directAnnotation).
FKBP1A	metacluster_27.29	ZNF583 (directAnnotation). ZNF583 (inferredBy_Orthology).
FKBP1A	taipale_tf_pairs__FLI1_FOXI1_GAAAACCGAAAN_CAP_repr	FLI1; FOXI1 (directAnnotation).
FKBP1A	taipale_cyt_meth__IRF6_ACCGAWACY_FL_meth	IRF6 (directAnnotation).
FKBP1A	transfac_pro__M04748	GABPA (directAnnotation).
FKBP1A	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).
FKBP1A	taipale_tf_pairs__ERF_TBX21_TMACACCGGAAG_CAP	ERF; TBX21 (directAnnotation).
FKBP1A	transfac_pro__M06102	ZNF16 (directAnnotation).
FKBP1A	transfac_pro__M06506	ZFP62 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
FKBP1A	"(21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE"	DB08520	small molecule
FKBP1A	"(3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine"	DB04012	small molecule
FKBP1A	"(3R)-4-(p-toluenesulfonyl)-1,4-thiazane-3-carboxylicacid-L-phenylalanine ethyl ester"	DB01712	small molecule
FKBP1A	"4-hydroxybutan-2-one"	DB04094	small molecule
FKBP1A	"Dorsomorphin"	DB08597	small molecule
FKBP1A	"FKB-001"	DB02888	small molecule
FKBP1A	"Gpi-1046"	DB01951	small molecule
FKBP1A	"GPI-1485"	DB05814	small molecule
FKBP1A	"Heptyl glucoside"	DB03338	small molecule
FKBP1A	"L-709,587"	DB03621	small molecule
FKBP1A	"Methyl Methylsulfinylmethyl Sulfide"	DB02311	small molecule
FKBP1A	"Myristic acid"	DB08231	small molecule
FKBP1A	"Pimecrolimus"	DB00337	small molecule
FKBP1A	"Tacrolimus"	DB00864	small molecule
FKBP1A	"{3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)	DB01723	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."