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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FJX1

Summary for FJX1

Gene information	Gene symbol	FJX1
	Ensembl ID	ENSG00000179431
	Entrez ID	24147
	Gene name	four-jointed box kinase 1
	Synonyms	FLJ22416\|FLJ25593
	Gene type	protein_coding
	UniProtAcc	Q86VR8

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Dataset with differentially expressed gene: FJX1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.367639	5.79e-17
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.412534	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.269099	2.65e-07

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Expression of FJX1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FJX1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FJX1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FJX1	hsa-miR-20a-5p	96.4669	NM_014344
FJX1	hsa-miR-106b-5p	96.4669	NM_014344
FJX1	hsa-miR-526b-3p	96.0033	NM_014344
FJX1	hsa-miR-93-5p	96.0033	NM_014344
FJX1	hsa-miR-17-5p	96.0033	NM_014344
FJX1	hsa-miR-20b-5p	96.0033	NM_014344
FJX1	hsa-miR-519d-3p	96.0033	NM_014344
FJX1	hsa-miR-106a-5p	96.0033	NM_014344
FJX1	hsa-miR-6832-3p	91.9736	NM_014344
FJX1	hsa-miR-4742-5p	90.8716	NM_014344
FJX1	hsa-miR-519a-3p	90.851	NM_014344
FJX1	hsa-miR-519c-3p	90.851	NM_014344
FJX1	hsa-miR-519b-3p	90.851	NM_014344
FJX1	hsa-miR-4778-5p	88.8594	NM_014344
FJX1	hsa-miR-4725-5p	88.6092	NM_014344
FJX1	hsa-miR-504-5p	88.6092	NM_014344
FJX1	hsa-miR-5681a	87.4405	NM_014344
FJX1	hsa-miR-548ar-3p	86.2419	NM_014344
FJX1	hsa-miR-2355-3p	84.9548	NM_014344
FJX1	hsa-miR-4306	84.1198	NM_014344
FJX1	hsa-miR-1972	83.7106	NM_014344
FJX1	hsa-miR-4796-3p	83.2452	NM_014344
FJX1	hsa-miR-4299	82.9214	NM_014344
FJX1	hsa-miR-3646	82.5316	NM_014344
FJX1	hsa-miR-6853-5p	82.1968	NM_014344
FJX1	hsa-miR-3686	81.4389	NM_014344
FJX1	hsa-miR-6511b-3p	80.6348	NM_014344
FJX1	hsa-miR-6511a-3p	80.6348	NM_014344
FJX1	hsa-miR-1185-2-3p	80.5792	NM_014344
FJX1	hsa-let-7f-2-3p	80.5792	NM_014344
FJX1	hsa-miR-1185-1-3p	80.5792	NM_014344
FJX1	hsa-miR-3163	80.1313	NM_014344

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Motifs and transcription factors (TFs) regulating FJX1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FJX1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
FJX1	hocomoco__KAISO_HUMAN.H11MO.2.A	ZBTB33 (directAnnotation).
FJX1	dbtfbs__ZNF121_HEK293_ENCSR224QDY_merged_N3	ZNF121 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."