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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FILIP1L

Summary for FILIP1L

Gene information	Gene symbol	FILIP1L
	Ensembl ID	ENSG00000168386
	Entrez ID	11259
	Gene name	filamin A interacting protein 1 like
	Synonyms	DOC-1\|GIP130
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: FILIP1L

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.420455	2.68e-35

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Expression of FILIP1L in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FILIP1L

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FILIP1L

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FILIP1L	hsa-miR-3646	97.8892	NM_014890
FILIP1L	hsa-miR-6515-5p	96.7308	NM_001042459
FILIP1L	hsa-miR-502-5p	96.4378	NM_001042459
FILIP1L	hsa-miR-3688-3p	95.8017	NM_014890
FILIP1L	hsa-miR-4771	93.0055	NM_001042459
FILIP1L	hsa-miR-6841-3p	92.8859	NM_001042459
FILIP1L	hsa-miR-548aw	92.2814	NM_001042459
FILIP1L	hsa-miR-6797-5p	91.774	NM_001042459
FILIP1L	hsa-miR-1249-5p	91.774	NM_001042459
FILIP1L	hsa-miR-4699-3p	88.3012	NM_001042459
FILIP1L	hsa-miR-4802-5p	87.3732	NM_001042459
FILIP1L	hsa-miR-1843	87.3732	NM_001042459
FILIP1L	hsa-miR-1273h-3p	87.264	NM_001042459
FILIP1L	hsa-miR-5010-5p	85.4487	NM_014890
FILIP1L	hsa-miR-4525	85.4487	NM_014890
FILIP1L	hsa-miR-4515	85.3418	NM_014890
FILIP1L	hsa-miR-1275	84.8791	NM_014890
FILIP1L	hsa-miR-6757-5p	84.8199	NM_001042459
FILIP1L	hsa-miR-519a-3p	84.2488	NM_001042459
FILIP1L	hsa-miR-519b-3p	84.2488	NM_001042459
FILIP1L	hsa-miR-519c-3p	84.2488	NM_001042459
FILIP1L	hsa-miR-4676-3p	84.0507	NM_014890
FILIP1L	hsa-miR-452-5p	84.0507	NM_014890
FILIP1L	hsa-miR-892c-3p	84.0507	NM_014890
FILIP1L	hsa-miR-8064	83.3665	NM_001042459
FILIP1L	hsa-miR-1185-1-3p	83.3571	NM_001042459
FILIP1L	hsa-miR-1185-2-3p	83.3571	NM_001042459
FILIP1L	hsa-miR-196a-3p	82.0128	NM_001042459

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Motifs and transcription factors (TFs) regulating FILIP1L

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FILIP1L	transfac_pro__M07608	ILF2; NFAT5; NFATC1; NFATC2; NFATC4 (directAnnotation).
FILIP1L	metacluster_22.11	NFE2 (directAnnotation).
FILIP1L	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
FILIP1L	transfac_pro__M06359	ZNF562 (directAnnotation).
FILIP1L	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
FILIP1L	transfac_pro__M06605	ZNF681 (directAnnotation).
FILIP1L	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
FILIP1L	metacluster_22.36	BACH2 (directAnnotation).
FILIP1L	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).
FILIP1L	metacluster_22.17	NFE2 (directAnnotation).
FILIP1L	tfdimers__MD00296	MYB; ZEB1 (directAnnotation).
FILIP1L	tfdimers__MD00074	SOX4; YY2 (directAnnotation).
FILIP1L	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
FILIP1L	transfac_pro__M03555	ILF2; NFATC2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."