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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: FHIT

Summary for FHIT

Gene information	Gene symbol	FHIT
	Ensembl ID	ENSG00000189283
	Entrez ID	2272
	Gene name	fragile histidine triad diadenosine triphosphatase
	Synonyms	AP3Aase\|FRA3B
	Gene type	protein_coding
	UniProtAcc	P49789

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Dataset with differentially expressed gene: FHIT

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.256929	4.28e-29
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.746171	0.00e+00

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Expression of FHIT in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FHIT

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FHIT

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FHIT	hsa-miR-4779	89.896	NM_001320900
FHIT	hsa-miR-940	86.4372	NM_001320900
FHIT	hsa-miR-6893-5p	86.4372	NM_001320900
FHIT	hsa-miR-6808-5p	86.4372	NM_001320900
FHIT	hsa-miR-340-5p	85.2468	NM_001320900
FHIT	hsa-miR-4259	84.9865	NM_001320900
FHIT	hsa-miR-1228-3p	84.7555	NM_001320900
FHIT	hsa-miR-7-5p	84.5349	NM_001320900
FHIT	hsa-miR-518c-5p	84.3588	NM_001166243
FHIT	hsa-miR-590-3p	84.2325	NM_001320900
FHIT	hsa-miR-6770-5p	83.5063	NM_001166243
FHIT	hsa-miR-4450	83.4905	NM_001166243
FHIT	hsa-miR-10522-5p	83.0559	NM_001166243
FHIT	hsa-miR-491-5p	82.1552	NM_001166243
FHIT	hsa-miR-5590-3p	81.1985	NM_001166243
FHIT	hsa-miR-142-5p	81.1985	NM_001166243
FHIT	hsa-miR-4678	80.5041	NM_001166243
FHIT	hsa-miR-6745	80.24	NM_001166243

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Motifs and transcription factors (TFs) regulating FHIT

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FHIT	metacluster_7.13	ZFX (directAnnotation).
FHIT	cisbp__M01863	ZNF711 (inferredBy_Orthology).
FHIT	metacluster_151.2	ZNF23 (directAnnotation).
FHIT	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
FHIT	transfac_pro__M05479	ZNF580 (directAnnotation).
FHIT	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
FHIT	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
FHIT	transfac_pro__M06071	ZNF814 (directAnnotation).
FHIT	transfac_pro__M05628	ZNF735 (directAnnotation).
FHIT	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
FHIT	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FHIT	jaspar__MA0079.5	SP1 (directAnnotation).
FHIT	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
FHIT	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
FHIT	cisbp__M00968	MTF2 (directAnnotation).
FHIT	metacluster_160.20	JUND; PRDM15 (directAnnotation).
FHIT	cisbp__M00341	PAX6 (directAnnotation).
FHIT	metacluster_198.3	ZFP64 (directAnnotation).
FHIT	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
FHIT	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
FHIT	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
FHIT	cisbp__M00788	ZFY (inferredBy_Orthology).
FHIT	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
FHIT	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
FHIT	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
FHIT	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
FHIT	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
FHIT	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
FHIT	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
FHIT	"Adenosine monotungstate"	DB02373	small molecule
FHIT	"Ado-P-Ch2-P-Ps-Ado"	DB04389	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."