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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: FGG

Summary for FGG

Gene information	Gene symbol	FGG
	Ensembl ID	ENSG00000171557
	Entrez ID	2266
	Gene name	fibrinogen gamma chain
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P02679

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Dataset with differentially expressed gene: FGG

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-3.5014	0.00e+00

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Expression of FGG in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FGG

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FGG

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FGG	hsa-miR-4795-3p	96.2159	NM_021870
FGG	hsa-miR-4496	95.8946	NM_000509
FGG	hsa-miR-4279	92.7132	NM_021870
FGG	hsa-miR-6507-3p	92.3491	NM_000509
FGG	hsa-miR-3935	91.8684	NM_000509
FGG	hsa-miR-548ar-3p	91.8283	NM_000509
FGG	hsa-miR-203a-3p	89.331	NM_000509
FGG	hsa-miR-126-5p	89.0947	NM_021870
FGG	hsa-miR-548f-3p	88.7956	NM_000509
FGG	hsa-miR-548bc	88.7956	NM_000509
FGG	hsa-miR-548a-3p	88.7956	NM_000509
FGG	hsa-miR-548az-3p	88.7956	NM_000509
FGG	hsa-miR-548e-3p	88.7956	NM_000509
FGG	hsa-miR-4666b	88.6612	NM_000509
FGG	hsa-miR-6817-3p	88.5213	NM_000509
FGG	hsa-miR-95-5p	88.4236	NM_021870
FGG	hsa-miR-4261	88.1486	NM_000509
FGG	hsa-miR-190a-3p	87.0861	NM_021870
FGG	hsa-miR-147b-5p	86.3901	NM_000509
FGG	hsa-miR-1305	86.0352	NM_000509
FGG	hsa-miR-1910-5p	84.7331	NM_021870
FGG	hsa-miR-6514-5p	84.5053	NM_000509
FGG	hsa-miR-3662	83.8878	NM_000509
FGG	hsa-miR-6126	83.6928	NM_021870
FGG	hsa-miR-6759-5p	83.2288	NM_021870
FGG	hsa-miR-577	81.9273	NM_000509

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Motifs and transcription factors (TFs) regulating FGG

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
FGG	"Alteplase"	DB00009	biotech
FGG	"Human thrombin"	DB11571	biotech
FGG	"Thrombin alfa"	DB11572	biotech
FGG	"Thrombin"	DB11300	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."