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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FGFRL1

Summary for FGFRL1

Gene information	Gene symbol	FGFRL1
	Ensembl ID	ENSG00000127418
	Entrez ID	53834
	Gene name	fibroblast growth factor receptor like 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q8N441

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Dataset with differentially expressed gene: FGFRL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.394929	6.65e-32
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.268644	2.51e-15

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Expression of FGFRL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FGFRL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FGFRL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FGFRL1	hsa-miR-6867-5p	100	NM_001004358
FGFRL1	hsa-miR-4673	99.9953	NM_001004356
FGFRL1	hsa-miR-4645-5p	99.9825	NM_001004356
FGFRL1	hsa-miR-4669	97.937	NM_001004356
FGFRL1	hsa-miR-3657	96.3314	NM_001004356
FGFRL1	hsa-miR-4686	94.9817	NM_001004358
FGFRL1	hsa-miR-103a-3p	94.6886	NM_001004358
FGFRL1	hsa-miR-107	94.6886	NM_001004358
FGFRL1	hsa-miR-4692	92.8067	NM_001004358
FGFRL1	hsa-miR-4514	92.4613	NM_001004358
FGFRL1	hsa-miR-6889-3p	89.0213	NM_001004356
FGFRL1	hsa-miR-519a-2-5p	88.8294	NM_001004358
FGFRL1	hsa-miR-520b-5p	88.8294	NM_001004358
FGFRL1	hsa-miR-198	88.7835	NM_001004356
FGFRL1	hsa-miR-7157-3p	87.63	NM_001004356
FGFRL1	hsa-miR-6737-3p	87.63	NM_001004356
FGFRL1	hsa-miR-302a-5p	87.2168	NM_001004358
FGFRL1	hsa-miR-6529-3p	87.0634	NM_001004356
FGFRL1	hsa-miR-618	86.9863	NM_001004358
FGFRL1	hsa-miR-210-3p	86.9393	NM_001004356
FGFRL1	hsa-miR-4520-5p	85.5789	NM_001004356
FGFRL1	hsa-miR-5008-3p	85.4239	NM_001004356
FGFRL1	hsa-miR-4455	83.3269	NM_001004356

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Motifs and transcription factors (TFs) regulating FGFRL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FGFRL1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
FGFRL1	jaspar__MA0079.5	SP1 (directAnnotation).
FGFRL1	hdpi__NFIX	NFIX (directAnnotation).
FGFRL1	metacluster_153.4	SOX12; SOX14; SRY (directAnnotation). SOX5 (inferredBy_Orthology).
FGFRL1	transfac_pro__M02896	SPI1 (inferredBy_Orthology).
FGFRL1	metacluster_74.6	HNF1A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."