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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FGF13

Summary for FGF13

Gene information	Gene symbol	FGF13
	Ensembl ID	ENSG00000129682
	Entrez ID	2258
	Gene name	fibroblast growth factor 13
	Synonyms	FGF2\|FHF2\|FLJ30672\|LINC00889
	Gene type	protein_coding
	UniProtAcc	Q92913

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Dataset with differentially expressed gene: FGF13

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.265571	5.25e-03
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.412588	5.15e-26

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Expression of FGF13 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FGF13

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FGF13

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FGF13	hsa-miR-3529-3p	99.6475	NM_001139501
FGF13	hsa-miR-4801	98.6265	NM_001139498
FGF13	hsa-miR-196a-1-3p	97.9092	NM_001139498
FGF13	hsa-miR-570-3p	97.6015	NM_001139498
FGF13	hsa-miR-4694-3p	97.4645	NM_001139498
FGF13	hsa-miR-4731-3p	97.2894	NM_001139498
FGF13	hsa-miR-302c-5p	96.4038	NM_001139498
FGF13	hsa-miR-4786-3p	95.802	NM_001139498
FGF13	hsa-miR-5004-3p	95.0031	NM_001139498
FGF13	hsa-miR-3675-5p	94.9961	NM_001139498
FGF13	hsa-miR-4775	94.5301	NM_001139498
FGF13	hsa-miR-449b-3p	93.9706	NM_001139498
FGF13	hsa-miR-1288-3p	93.6035	NM_001139498
FGF13	hsa-miR-4762-5p	93.4546	NM_001139501
FGF13	hsa-miR-5581-3p	93.2934	NM_001139498
FGF13	hsa-miR-190b-3p	93.1456	NM_001139498
FGF13	hsa-miR-8068	93.0995	NM_001139501
FGF13	hsa-miR-6792-5p	91.622	NM_001139498
FGF13	hsa-miR-340-5p	90.4102	NM_001139498
FGF13	hsa-miR-6732-3p	90.1983	NM_001139498
FGF13	hsa-miR-891b	90.0863	NM_001139498
FGF13	hsa-miR-6872-3p	89.9471	NM_001139498
FGF13	hsa-miR-3679-5p	89.8975	NM_001139501
FGF13	hsa-miR-3169	89.7981	NM_001139498
FGF13	hsa-miR-6729-3p	89.3818	NM_001139501
FGF13	hsa-miR-2052	89.2805	NM_001139501
FGF13	hsa-miR-2113	88.7506	NM_001139501
FGF13	hsa-miR-19b-2-5p	88.4486	NM_001139501
FGF13	hsa-miR-19b-1-5p	88.4486	NM_001139501
FGF13	hsa-miR-584-3p	88.1859	NM_001139498
FGF13	hsa-miR-1185-5p	87.648	NM_001139501
FGF13	hsa-miR-19a-5p	87.1983	NM_001139501
FGF13	hsa-miR-345-3p	87.0146	NM_001139498
FGF13	hsa-miR-10522-5p	86.9305	NM_001139498
FGF13	hsa-miR-590-3p	86.8507	NM_001139498
FGF13	hsa-miR-539-5p	86.7104	NM_001139498
FGF13	hsa-miR-4283	86.6128	NM_001139498
FGF13	hsa-miR-4719	85.2131	NM_001139498
FGF13	hsa-miR-5699-3p	85.0772	NM_001139501
FGF13	hsa-miR-320a-5p	84.8885	NM_001139498
FGF13	hsa-miR-5692b	84.821	NM_001139501
FGF13	hsa-miR-5692c	84.821	NM_001139501
FGF13	hsa-miR-6715a-3p	84.7679	NM_001139498
FGF13	hsa-miR-552-5p	84.0738	NM_001139501
FGF13	hsa-miR-4799-5p	83.4072	NM_001139498
FGF13	hsa-miR-6514-3p	83.2176	NM_001139501
FGF13	hsa-miR-4421	83.0929	NM_001139501
FGF13	hsa-miR-4503	83.0372	NM_001139501
FGF13	hsa-miR-200a-5p	81.8612	NM_001139501
FGF13	hsa-miR-200b-5p	81.8612	NM_001139501

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Motifs and transcription factors (TFs) regulating FGF13

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FGF13	transfac_pro__M05993	ZNF711 (directAnnotation).
FGF13	hocomoco__FOXP1_HUMAN.H11MO.0.A	FOXP1 (directAnnotation).
FGF13	metacluster_22.16	BACH2 (directAnnotation).
FGF13	metacluster_110.2	ZNF549 (directAnnotation).
FGF13	metacluster_22.34	BACH2 (directAnnotation).
FGF13	swissregulon__mm__Atf2	ATF2 (inferredBy_Orthology).
FGF13	metacluster_22.1	MAFF (inferredBy_Orthology).
FGF13	transfac_pro__M06117	ZNF23 (directAnnotation).
FGF13	metacluster_22.37	BACH1 (directAnnotation).
FGF13	metacluster_22.18	BACH2 (inferredBy_Orthology).
FGF13	swissregulon__hs__EZH2	EZH2 (directAnnotation).
FGF13	metacluster_187.7	FEZF1; FEZF1; ZNF384; ZNF384; ZNF384 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
FGF13	metacluster_150.9	VSX2; VSX2 (directAnnotation).
FGF13	metacluster_155.30	ZNF254 (directAnnotation).
FGF13	metacluster_22.23	NFE2 (directAnnotation).
FGF13	transfac_pro__M06404	ZNF497 (directAnnotation).
FGF13	transfac_pro__M06969	EBF4 (inferredBy_Orthology).
FGF13	transfac_pro__M01253	CNOT3 (directAnnotation).
FGF13	transfac_pro__M04817	ZBTB33 (directAnnotation).
FGF13	transfac_pro__M02896	SPI1 (inferredBy_Orthology).
FGF13	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
FGF13	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."