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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FGD6

Summary for FGD6

Gene information	Gene symbol	FGD6
	Ensembl ID	ENSG00000180263
	Entrez ID	55785
	Gene name	FYVE, RhoGEF and PH domain containing 6
	Synonyms	FLJ11183\|ZFYVE24
	Gene type	protein_coding
	UniProtAcc	Q6ZV73

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Dataset with differentially expressed gene: FGD6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.452305	0.00e+00

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Expression of FGD6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FGD6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FGD6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FGD6	hsa-miR-153-5p	98.4869	NM_018351
FGD6	hsa-miR-4328	97.8792	NM_018351
FGD6	hsa-miR-1250-3p	97.7621	NM_018351
FGD6	hsa-miR-144-3p	96.5357	NM_018351
FGD6	hsa-miR-4256	96.1079	NM_018351
FGD6	hsa-miR-11181-5p	96.1079	NM_018351
FGD6	hsa-miR-6866-5p	95.412	NM_018351
FGD6	hsa-miR-6809-3p	94.5373	NM_018351
FGD6	hsa-miR-5692a	94.3935	NM_018351
FGD6	hsa-miR-34a-5p	93.9505	NM_018351
FGD6	hsa-miR-449a	93.9505	NM_018351
FGD6	hsa-miR-3145-3p	93.7384	NM_018351
FGD6	hsa-miR-5590-3p	93.6439	NM_018351
FGD6	hsa-miR-3143	93.0893	NM_018351
FGD6	hsa-miR-142-5p	92.3621	NM_018351
FGD6	hsa-miR-449b-5p	91.864	NM_018351
FGD6	hsa-miR-34c-5p	91.864	NM_018351
FGD6	hsa-miR-4753-3p	91.6129	NM_018351
FGD6	hsa-miR-3662	91.0041	NM_018351
FGD6	hsa-miR-4803	90.4081	NM_018351
FGD6	hsa-miR-548l	90.3772	NM_018351
FGD6	hsa-miR-340-5p	90.2876	NM_018351
FGD6	hsa-miR-548x-5p	89.7765	NM_018351
FGD6	hsa-miR-548g-5p	89.7765	NM_018351
FGD6	hsa-miR-548aj-5p	89.7765	NM_018351
FGD6	hsa-miR-548f-5p	89.7765	NM_018351
FGD6	hsa-miR-4302	89.5796	NM_018351
FGD6	hsa-miR-4500	89.4441	NM_018351
FGD6	hsa-miR-4533	88.6118	NM_018351
FGD6	hsa-miR-548au-3p	86.8475	NM_018351
FGD6	hsa-miR-30d-5p	86.7081	NM_018351
FGD6	hsa-miR-30c-5p	86.7081	NM_018351
FGD6	hsa-miR-30a-5p	86.7081	NM_018351
FGD6	hsa-miR-30e-5p	86.7081	NM_018351
FGD6	hsa-miR-30b-5p	86.7081	NM_018351
FGD6	hsa-miR-4722-3p	85.4826	NM_018351
FGD6	hsa-miR-4760-5p	85.0723	NM_018351
FGD6	hsa-miR-1827	85.0652	NM_018351
FGD6	hsa-miR-1233-3p	84.5618	NM_018351
FGD6	hsa-miR-6727-3p	84.528	NM_018351
FGD6	hsa-miR-548aj-3p	84.434	NM_018351
FGD6	hsa-miR-548x-3p	84.434	NM_018351
FGD6	hsa-miR-4713-3p	84.1709	NM_018351
FGD6	hsa-miR-6876-5p	84.0634	NM_018351
FGD6	hsa-let-7c-5p	83.7738	NM_018351
FGD6	hsa-let-7b-5p	83.7738	NM_018351
FGD6	hsa-let-7e-5p	83.7738	NM_018351
FGD6	hsa-let-7f-5p	83.7738	NM_018351
FGD6	hsa-let-7i-5p	83.7738	NM_018351
FGD6	hsa-let-7a-5p	83.7738	NM_018351

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Motifs and transcription factors (TFs) regulating FGD6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FGD6	metacluster_160.20	JUND; PRDM15 (directAnnotation).
FGD6	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
FGD6	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
FGD6	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."