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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FEM1B

Summary for FEM1B

Gene information	Gene symbol	FEM1B
	Ensembl ID	ENSG00000169018
	Entrez ID	10116
	Gene name	fem-1 homolog B
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9UK73

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Dataset with differentially expressed gene: FEM1B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.498322	0.00e+00

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Expression of FEM1B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FEM1B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FEM1B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FEM1B	hsa-miR-607	99.0948	NM_015322
FEM1B	hsa-miR-1250-3p	96.8058	NM_015322
FEM1B	hsa-miR-153-5p	96.2892	NM_015322
FEM1B	hsa-miR-5682	96.262	NM_015322
FEM1B	hsa-miR-7157-5p	94.2637	NM_015322
FEM1B	hsa-miR-585-5p	93.4926	NM_015322
FEM1B	hsa-miR-548c-3p	93.3379	NM_015322
FEM1B	hsa-miR-4310	93.3227	NM_015322
FEM1B	hsa-miR-29b-3p	92.0543	NM_015322
FEM1B	hsa-miR-29a-3p	92.0543	NM_015322
FEM1B	hsa-miR-29c-3p	92.0543	NM_015322
FEM1B	hsa-miR-4672	91.8322	NM_015322
FEM1B	hsa-miR-96-5p	91.1472	NM_015322
FEM1B	hsa-miR-128-3p	90.9899	NM_015322
FEM1B	hsa-miR-216a-3p	90.9899	NM_015322
FEM1B	hsa-miR-3120-5p	90.0686	NM_015322
FEM1B	hsa-miR-513a-3p	89.963	NM_015322
FEM1B	hsa-miR-513c-3p	89.963	NM_015322
FEM1B	hsa-miR-3681-3p	89.6439	NM_015322
FEM1B	hsa-miR-4724-5p	89.56	NM_015322
FEM1B	hsa-miR-5692a	88.6247	NM_015322
FEM1B	hsa-miR-1271-5p	88.4839	NM_015322
FEM1B	hsa-miR-12133	88.4839	NM_015322
FEM1B	hsa-miR-4679	88.1516	NM_015322
FEM1B	hsa-miR-3606-3p	87.0733	NM_015322
FEM1B	hsa-miR-4275	86.7672	NM_015322
FEM1B	hsa-miR-4476	86.6188	NM_015322
FEM1B	hsa-miR-6876-5p	86.6188	NM_015322
FEM1B	hsa-miR-320a-3p	85.9154	NM_015322
FEM1B	hsa-miR-320c	85.9154	NM_015322
FEM1B	hsa-miR-320d	85.9154	NM_015322
FEM1B	hsa-miR-320b	85.9154	NM_015322
FEM1B	hsa-miR-4429	85.9154	NM_015322
FEM1B	hsa-miR-3913-3p	85.2479	NM_015322
FEM1B	hsa-miR-3121-3p	85.1975	NM_015322
FEM1B	hsa-miR-6083	85.0461	NM_015322
FEM1B	hsa-miR-600	84.2022	NM_015322
FEM1B	hsa-miR-32-3p	82.6772	NM_015322
FEM1B	hsa-miR-3140-3p	82.6111	NM_015322
FEM1B	hsa-miR-335-3p	81.8122	NM_015322
FEM1B	hsa-miR-5088-3p	81.0564	NM_015322
FEM1B	hsa-miR-6881-3p	80.5597	NM_015322
FEM1B	hsa-miR-582-5p	80.2484	NM_015322
FEM1B	hsa-miR-4659b-5p	80.0934	NM_015322

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Motifs and transcription factors (TFs) regulating FEM1B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FEM1B	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FEM1B	metacluster_7.13	ZFX (directAnnotation).
FEM1B	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
FEM1B	metacluster_160.20	JUND; PRDM15 (directAnnotation).
FEM1B	metacluster_198.3	ZFP64 (directAnnotation).
FEM1B	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
FEM1B	cisbp__M00788	ZFY (inferredBy_Orthology).
FEM1B	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
FEM1B	metacluster_175.1	ZNF283 (directAnnotation).
FEM1B	hdpi__ZNF304	ZNF304 (directAnnotation).
FEM1B	metacluster_151.2	ZNF23 (directAnnotation).
FEM1B	transfac_pro__M03806	ZBTB7C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."