DRMref Logo

Home

Download

Statistics

Landscape

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Datasets with differential expression of this gene

leaf

Expression of this gene in the resistant group across all datasets and cell types

leaf

Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

leaf

Known drug resistance mechanisms of this gene (This gene does not contain this module)

leaf

MicroRNAs (miRNAs) regulating this gene

leaf

Motifs and transcription factors (TFs) regulating this gene

leaf

Acts as a transcription factor (This gene does not contain this module)

leaf

Acts as a drug target< (This gene does not contain this module)

Gene: FCMR

Summary for FCMR

Gene informationGene symbol

FCMR

Ensembl ID

ENSG00000162894

Entrez ID

9214

Gene nameFc mu receptor
SynonymsFAIM3|FcmuR|TOSO
Gene typeprotein_coding
UniProtAcc

O60667


Top

Dataset with differentially expressed gene: FCMR

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE140440

DU145 and PC cell linesCell lineProstate cancerProstate cancerChemotherapydocetaxelNAMalignant cells2.678258.93e-05

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostB cells0.4123020.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreNK cells0.2600920.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreB cells0.4014130.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreCD8+ T cells0.3528280.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreCD4+ T cells0.3099850.00e+00

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostCD4+ T cells-0.2676950.00e+00

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postB cells0.3004647.17e-03

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpreMalignant cells-0.3368840.00e+00

GSE152469

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibNAMalignant cells-0.3704250.00e+00

Top

Expression of FCMR in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

Top

Significant ligand-receptor pairs related to FCMR

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating FCMR

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
FCMRhsa-miR-873-3p93.0445NM_001142473
FCMRhsa-miR-453491.0135NM_001142473
FCMRhsa-miR-431190.0831NM_001142473
FCMRhsa-miR-138-2-3p88.5739NM_001193338
FCMRhsa-miR-429187.5706NM_001142473
FCMRhsa-miR-302e85.6925NM_001142473
FCMRhsa-miR-808285.2498NM_001142473
FCMRhsa-miR-3151-5p80.8011NM_001142473
Page: 1

Top

Motifs and transcription factors (TFs) regulating FCMR

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
FCMRtransfac_pro__M01150DMRTA2 (directAnnotation).
FCMRtransfac_pro__M05888ZNF467 (inferredBy_Orthology).
FCMRmetacluster_23.6ZNF440; ZSCAN26 (directAnnotation).
FCMRtransfac_pro__M02935ZNF281 (inferredBy_Orthology).
FCMRtransfac_pro__M05986ZNF394 (inferredBy_Orthology).
FCMRtransfac_pro__M06583ZNF845 (directAnnotation).
FCMRflyfactorsurvey__pho_SOLEXA_F1-3YY1 (inferredBy_Orthology).
FCMRtaipale_tf_pairs__ELK1_FOXI1_RSCGGAANRWMAACAN_CAP_reprELK1; FOXI1 (directAnnotation).
FCMRtransfac_pro__M06295ZNF667 (inferredBy_Orthology).
FCMRtransfac_pro__M06951TEF (directAnnotation).
FCMRtransfac_pro__M06438ZNF227 (directAnnotation).
FCMRtaipale_tf_pairs__POU2F1_EOMES_ARGTGTNNNAATATKYNNNCRCNN_CAP_reprEOMES; POU2F1 (directAnnotation).
Page: 1

Top

Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."