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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FCHSD2

Summary for FCHSD2

Gene information	Gene symbol	FCHSD2
	Ensembl ID	ENSG00000137478
	Entrez ID	9873
	Gene name	FCH and double SH3 domains 2
	Synonyms	KIAA0769\|SH3MD3
	Gene type	protein_coding
	UniProtAcc	O94868

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Dataset with differentially expressed gene: FCHSD2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.337635	9.11e-44

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Expression of FCHSD2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FCHSD2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FCHSD2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FCHSD2	hsa-miR-3529-3p	98.9826	NM_014824
FCHSD2	hsa-miR-3065-5p	98.9741	NM_014824
FCHSD2	hsa-miR-4272	97.7281	NM_014824
FCHSD2	hsa-miR-3190-3p	96.8222	NM_014824
FCHSD2	hsa-miR-4699-5p	95.3627	NM_014824
FCHSD2	hsa-miR-6887-3p	95.2157	NM_014824
FCHSD2	hsa-miR-4695-5p	95.0733	NM_014824
FCHSD2	hsa-miR-1208	94.3108	NM_014824
FCHSD2	hsa-miR-4434	93.5508	NM_014824
FCHSD2	hsa-miR-4516	93.5508	NM_014824
FCHSD2	hsa-miR-5703	93.5508	NM_014824
FCHSD2	hsa-miR-506-3p	92.3705	NM_014824
FCHSD2	hsa-miR-124-3p	92.3705	NM_014824
FCHSD2	hsa-miR-3163	91.8748	NM_014824
FCHSD2	hsa-miR-605-5p	91.7439	NM_014824
FCHSD2	hsa-miR-6507-5p	89.9115	NM_014824
FCHSD2	hsa-miR-3622a-5p	89.711	NM_014824
FCHSD2	hsa-miR-3920	89.3629	NM_014824
FCHSD2	hsa-miR-2113	89.2456	NM_014824
FCHSD2	hsa-miR-508-3p	88.8185	NM_014824
FCHSD2	hsa-miR-646	88.7087	NM_014824
FCHSD2	hsa-miR-3613-3p	88.6432	NM_014824
FCHSD2	hsa-miR-4511	88.4353	NM_014824
FCHSD2	hsa-miR-924	87.1156	NM_014824
FCHSD2	hsa-miR-421	86.9478	NM_014824
FCHSD2	hsa-miR-3926	86.4949	NM_014824
FCHSD2	hsa-miR-18b-5p	86.4066	NM_014824
FCHSD2	hsa-miR-4735-3p	86.4066	NM_014824
FCHSD2	hsa-miR-18a-5p	86.4066	NM_014824
FCHSD2	hsa-miR-3133	86.2352	NM_014824
FCHSD2	hsa-miR-4524a-5p	85.8383	NM_014824
FCHSD2	hsa-miR-4524b-5p	85.8383	NM_014824
FCHSD2	hsa-miR-3148	85.637	NM_014824
FCHSD2	hsa-miR-5691	85.4647	NM_014824
FCHSD2	hsa-miR-6805-3p	85.4647	NM_014824
FCHSD2	hsa-miR-5694	84.8529	NM_014824
FCHSD2	hsa-miR-3064-3p	84.5568	NM_014824
FCHSD2	hsa-miR-1236-3p	84.1756	NM_014824
FCHSD2	hsa-miR-374c-5p	83.9111	NM_014824
FCHSD2	hsa-miR-655-3p	83.9111	NM_014824
FCHSD2	hsa-miR-5589-3p	83.8059	NM_014824
FCHSD2	hsa-miR-330-3p	83.7463	NM_014824
FCHSD2	hsa-miR-4252	83.6075	NM_014824
FCHSD2	hsa-miR-4660	83.28	NM_014824
FCHSD2	hsa-miR-650	83.2703	NM_014824
FCHSD2	hsa-miR-3612	83.2703	NM_014824
FCHSD2	hsa-miR-190b-3p	83.0451	NM_014824
FCHSD2	hsa-miR-3173-3p	82.6485	NM_014824
FCHSD2	hsa-miR-12118	82.6485	NM_014824
FCHSD2	hsa-miR-6891-5p	82.6485	NM_014824

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Motifs and transcription factors (TFs) regulating FCHSD2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FCHSD2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
FCHSD2	transfac_pro__M02089	E2F3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."