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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: FCGR1A

Summary for FCGR1A

Gene information	Gene symbol	FCGR1A
	Ensembl ID	ENSG00000150337
	Entrez ID	2209
	Gene name	Fc gamma receptor Ia
	Synonyms	CD64\|CD64A\|FCG1\|FcgammaRI\|FcgammaRIa\|FCGR1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: FCGR1A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.452497	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	0.363698	1.17e-04
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.329045	1.13e-16
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.365482	5.84e-14
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	0.344157	0.00e+00

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Expression of FCGR1A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FCGR1A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FCGR1A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FCGR1A	hsa-miR-4251	95.3655	NM_000566
FCGR1A	hsa-miR-517-5p	94.6101	NM_000566
FCGR1A	hsa-miR-6856-3p	87.2599	NM_000566
FCGR1A	hsa-miR-2681-5p	86.7997	NM_000566
FCGR1A	hsa-miR-4729	86.6313	NM_000566
FCGR1A	hsa-miR-6818-3p	85.9172	NM_000566
FCGR1A	hsa-miR-422a	82.3545	NM_000566
FCGR1A	hsa-miR-378d	82.3545	NM_000566
FCGR1A	hsa-miR-378f	82.3545	NM_000566
FCGR1A	hsa-miR-378e	82.3545	NM_000566
FCGR1A	hsa-miR-378c	82.3545	NM_000566
FCGR1A	hsa-miR-378h	82.3545	NM_000566
FCGR1A	hsa-miR-378a-3p	82.3545	NM_000566
FCGR1A	hsa-miR-378i	82.3545	NM_000566
FCGR1A	hsa-miR-378b	82.3545	NM_000566
FCGR1A	hsa-miR-3182	82.0656	NM_000566

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Motifs and transcription factors (TFs) regulating FCGR1A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FCGR1A	hocomoco__ZN652_HUMAN.H11MO.0.D	ZNF652 (directAnnotation).
FCGR1A	taipale_tf_pairs__GCM1_CEBPB_MTRSGGGNNNNNNTTRCGYAAN_CAP	CEBPB; GCM1 (directAnnotation).
FCGR1A	metacluster_168.4	ZNF652 (directAnnotation).
FCGR1A	transfac_pro__M05542	SNAPC4 (directAnnotation).
FCGR1A	homer__TWGTCTGV_Smad3	SMAD3 (inferredBy_Orthology).
FCGR1A	transfac_pro__M06131	ZNF10 (directAnnotation).
FCGR1A	transfac_pro__M06246	ZNF177 (directAnnotation).
FCGR1A	metacluster_79.18	ZNF81; ZNF81 (directAnnotation).
FCGR1A	transfac_pro__M05387	ZNF653 (inferredBy_Orthology).
FCGR1A	metacluster_131.2	ZNF257 (directAnnotation).
FCGR1A	metacluster_90.6	ESRRA; ESRRA; ESRRA; ESRRA; ESRRA; ESRRG; ESRRG; ESRRG; ESRRG; NR5A1; NR5A1; NR5A1; NR5A2; NR5A2; NR5A2; NR5A2 (directAnnotation). AR; ESR1; ESR2; ESRRA; ESRRA; ESRRA; ESRRB; ESRRB; ESRRG; ESRRG; NR3C1; NR3C2; NR5A2; PGR (inferredBy_Orthology).
FCGR1A	swissregulon__hs__ETV6	ETV6 (directAnnotation).
FCGR1A	transfac_pro__M05560	AEBP2 (directAnnotation).
FCGR1A	transfac_pro__M06553	ZNF420 (directAnnotation).
FCGR1A	tfdimers__MD00145	ELF1; ELF2; ELK1; ELK4; ERF; ERG; ETS1; ETS2; ETV7; FLI1; TCF7L2 (directAnnotation).
FCGR1A	transfac_pro__M06749	ZNF222 (directAnnotation).
FCGR1A	tfdimers__MD00349	GABPA; YY2 (directAnnotation).
FCGR1A	transfac_pro__M05730	ZNF630 (directAnnotation).
FCGR1A	transfac_pro__M05896	ZNF713 (directAnnotation).
FCGR1A	metacluster_79.1	ZNF713; ZNF713; ZNF713 (directAnnotation).
FCGR1A	transfac_pro__M06839	ZNF263 (inferredBy_Orthology).
FCGR1A	transfac_pro__M06070	ZNF732 (directAnnotation).
FCGR1A	transfac_pro__M06398	ZNF761 (directAnnotation).
FCGR1A	tfdimers__MD00446	PDX1; TFAP2C (directAnnotation).
FCGR1A	tfdimers__MD00295	EBF1; STAT6 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
FCGR1A	"Alemtuzumab"	DB00087	biotech
FCGR1A	"Bevacizumab"	DB00112	biotech
FCGR1A	"Catumaxomab"	DB06607	biotech
FCGR1A	"Cetuximab"	DB00002	biotech
FCGR1A	"Daclizumab"	DB00111	biotech
FCGR1A	"Etanercept"	DB00005	biotech
FCGR1A	"Gemtuzumab ozogamicin"	DB00056	biotech
FCGR1A	"Human immunoglobulin G"	DB00028	biotech
FCGR1A	"Natalizumab"	DB00108	biotech
FCGR1A	"Palivizumab"	DB00110	biotech
FCGR1A	"Porfimer sodium"	DB00707	small molecule
FCGR1A	"Sarilumab"	DB11767	biotech
FCGR1A	"Trastuzumab deruxtecan"	DB14962	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."