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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FCAR

Summary for FCAR

Gene information	Gene symbol	FCAR
	Ensembl ID	ENSG00000276858
	Entrez ID	2204
	Gene name	Fc alpha receptor
	Synonyms	CD89\|FcalphaR\|FcalphaRI
	Gene type	protein_coding
	UniProtAcc	P24071

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Dataset with differentially expressed gene: FCAR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.26617	1.35e-10

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Expression of FCAR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FCAR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FCAR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FCAR	hsa-miR-5697	97.4538	NM_133271
FCAR	hsa-miR-3613-3p	96.4115	NM_133271
FCAR	hsa-miR-372-5p	89.5871	NM_133271
FCAR	hsa-miR-3654	88.7507	NM_133271
FCAR	hsa-miR-616-5p	88.4217	NM_133271
FCAR	hsa-miR-371b-5p	88.4217	NM_133271
FCAR	hsa-miR-373-5p	88.4217	NM_133271
FCAR	hsa-miR-676-5p	85.9355	NM_133271
FCAR	hsa-miR-4797-3p	85.5909	NM_133271
FCAR	hsa-miR-6780a-5p	83.129	NM_133271
FCAR	hsa-miR-3065-5p	82.5952	NM_133271
FCAR	hsa-miR-6833-3p	82.3199	NM_133271
FCAR	hsa-miR-3163	81.7911	NM_133271
FCAR	hsa-miR-1268b	80.6556	NM_133271
FCAR	hsa-miR-1268a	80.6556	NM_133271
FCAR	hsa-miR-1297	80.3289	NM_133271
FCAR	hsa-miR-4728-5p	80.0292	NM_133271

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Motifs and transcription factors (TFs) regulating FCAR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FCAR	metacluster_22.18	BACH2 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."