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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FBXO45

Summary for FBXO45

Gene information	Gene symbol	FBXO45
	Ensembl ID	ENSG00000174013
	Entrez ID	200933
	Gene name	F-box protein 45
	Synonyms	Fbx45
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: FBXO45

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.256749	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.343617	3.70e-21

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Expression of FBXO45 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FBXO45

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FBXO45

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FBXO45	hsa-miR-3658	98.9123	NM_001105573
FBXO45	hsa-miR-1304-5p	98.8096	NM_001105573
FBXO45	hsa-miR-548c-3p	98.1729	NM_001105573
FBXO45	hsa-miR-3925-3p	97.7499	NM_001105573
FBXO45	hsa-miR-7-2-3p	97.6824	NM_001105573
FBXO45	hsa-miR-7-1-3p	97.6824	NM_001105573
FBXO45	hsa-miR-5692a	96.1339	NM_001105573
FBXO45	hsa-miR-30b-5p	95.9893	NM_001105573
FBXO45	hsa-miR-30e-5p	95.9893	NM_001105573
FBXO45	hsa-miR-30a-5p	95.9893	NM_001105573
FBXO45	hsa-miR-30d-5p	95.9893	NM_001105573
FBXO45	hsa-miR-30c-5p	95.9893	NM_001105573
FBXO45	hsa-miR-3065-3p	95.1599	NM_001105573
FBXO45	hsa-miR-3941	94.9473	NM_001105573
FBXO45	hsa-miR-624-3p	93.8857	NM_001105573
FBXO45	hsa-miR-3124-3p	93.6782	NM_001105573
FBXO45	hsa-miR-4692	93.465	NM_001105573
FBXO45	hsa-miR-4514	93.465	NM_001105573
FBXO45	hsa-miR-590-3p	93.0739	NM_001105573
FBXO45	hsa-miR-4659a-3p	92.9145	NM_001105573
FBXO45	hsa-miR-4659b-3p	92.9145	NM_001105573
FBXO45	hsa-miR-320e	91.8774	NM_001105573
FBXO45	hsa-miR-627-3p	91.5647	NM_001105573
FBXO45	hsa-miR-877-3p	91.3454	NM_001105573
FBXO45	hsa-miR-10226	90.9406	NM_001105573
FBXO45	hsa-miR-103a-2-5p	90.5375	NM_001105573
FBXO45	hsa-miR-103a-1-5p	90.5375	NM_001105573
FBXO45	hsa-miR-3188	89.7817	NM_001105573
FBXO45	hsa-miR-498-5p	89.6644	NM_001105573
FBXO45	hsa-miR-937-5p	89.5166	NM_001105573
FBXO45	hsa-miR-548as-3p	89.3228	NM_001105573
FBXO45	hsa-miR-520d-5p	89.2244	NM_001105573
FBXO45	hsa-miR-8485	88.7355	NM_001105573
FBXO45	hsa-miR-4510	88.0423	NM_001105573
FBXO45	hsa-miR-6130	88.0423	NM_001105573
FBXO45	hsa-miR-4279	88.0103	NM_001105573
FBXO45	hsa-miR-95-5p	88.0072	NM_001105573
FBXO45	hsa-miR-766-3p	88.0006	NM_001105573
FBXO45	hsa-miR-5003-3p	87.9953	NM_001105573
FBXO45	hsa-miR-1-5p	87.9788	NM_001105573
FBXO45	hsa-miR-4778-3p	87.7114	NM_001105573
FBXO45	hsa-miR-515-5p	87.2524	NM_001105573
FBXO45	hsa-miR-6127	86.7421	NM_001105573
FBXO45	hsa-miR-6133	86.7421	NM_001105573
FBXO45	hsa-miR-6129	86.7421	NM_001105573
FBXO45	hsa-miR-524-5p	86.575	NM_001105573
FBXO45	hsa-miR-383-3p	85.9234	NM_001105573
FBXO45	hsa-miR-140-5p	85.7404	NM_001105573
FBXO45	hsa-miR-891a-3p	85.6152	NM_001105573
FBXO45	hsa-miR-603	85.5698	NM_001105573

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Motifs and transcription factors (TFs) regulating FBXO45

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FBXO45	cisbp__M00341	PAX6 (directAnnotation).
FBXO45	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
FBXO45	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
FBXO45	metacluster_175.1	ZNF283 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."