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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FBXO4

Summary for FBXO4

Gene information	Gene symbol	FBXO4
	Ensembl ID	ENSG00000151876
	Entrez ID	26272
	Gene name	F-box protein 4
	Synonyms	FBX4
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: FBXO4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.73214	1.37e-07

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Expression of FBXO4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FBXO4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FBXO4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FBXO4	hsa-miR-3180-5p	97.3468	NM_012176
FBXO4	hsa-miR-1277-5p	96.332	NM_033484
FBXO4	hsa-miR-3153	95.8439	NM_033484
FBXO4	hsa-miR-6739-5p	95.614	NM_033484
FBXO4	hsa-miR-6733-5p	95.614	NM_033484
FBXO4	hsa-miR-338-5p	95.5446	NM_033484
FBXO4	hsa-miR-892c-5p	93.8795	NM_033484
FBXO4	hsa-miR-450a-1-3p	93.1153	NM_033484
FBXO4	hsa-miR-4666a-3p	92.5694	NM_033484
FBXO4	hsa-miR-8485	91.9139	NM_033484
FBXO4	hsa-miR-5585-3p	91.5346	NM_033484
FBXO4	hsa-miR-377-3p	91.4857	NM_033484
FBXO4	hsa-miR-548p	89.4812	NM_033484
FBXO4	hsa-miR-548c-3p	89.0883	NM_012176
FBXO4	hsa-miR-335-3p	88.9377	NM_033484
FBXO4	hsa-miR-5692b	88.5245	NM_033484
FBXO4	hsa-miR-5692c	88.5245	NM_033484
FBXO4	hsa-miR-3163	88.26	NM_012176
FBXO4	hsa-miR-3941	87.5879	NM_033484
FBXO4	hsa-miR-513a-3p	87.2599	NM_012176
FBXO4	hsa-miR-513c-3p	87.2599	NM_012176
FBXO4	hsa-miR-153-3p	87.0916	NM_033484
FBXO4	hsa-miR-603	86.8361	NM_033484
FBXO4	hsa-miR-146b-5p	86.5332	NM_033484
FBXO4	hsa-miR-146a-5p	86.5332	NM_033484
FBXO4	hsa-miR-7153-5p	86.5332	NM_033484
FBXO4	hsa-miR-4668-5p	86.1508	NM_033484
FBXO4	hsa-miR-3613-3p	85.8531	NM_033484
FBXO4	hsa-miR-3148	85.0249	NM_033484
FBXO4	hsa-miR-578	84.9432	NM_012176
FBXO4	hsa-miR-5011-5p	84.5774	NM_033484
FBXO4	hsa-miR-5692a	83.9109	NM_012176
FBXO4	hsa-miR-6779-3p	83.693	NM_033484
FBXO4	hsa-miR-3606-3p	83.1463	NM_012176
FBXO4	hsa-miR-199b-5p	82.4428	NM_033484
FBXO4	hsa-miR-199a-5p	82.4428	NM_033484
FBXO4	hsa-miR-6715a-3p	81.5592	NM_033484
FBXO4	hsa-miR-584-3p	80.4651	NM_012176
FBXO4	hsa-miR-4489	80.2653	NM_012176

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Motifs and transcription factors (TFs) regulating FBXO4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."