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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FBXO28

Summary for FBXO28

Gene information	Gene symbol	FBXO28
	Ensembl ID	ENSG00000143756
	Entrez ID	23219
	Gene name	F-box protein 28
	Synonyms	CENP-30\|Fbx28\|FLJ10766\|KIAA0483
	Gene type	protein_coding
	UniProtAcc	Q9NVF7

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Dataset with differentially expressed gene: FBXO28

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.280539	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.27821	4.02e-22

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Expression of FBXO28 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FBXO28

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FBXO28

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FBXO28	hsa-miR-8080	99.6627	NM_001136115
FBXO28	hsa-miR-12136	98.3997	NM_015176
FBXO28	hsa-miR-1297	97.9541	NM_001136115
FBXO28	hsa-miR-3180-5p	97.7879	NM_001136115
FBXO28	hsa-miR-26a-5p	97.416	NM_001136115
FBXO28	hsa-miR-26b-5p	97.416	NM_001136115
FBXO28	hsa-miR-4516	97.0144	NM_001136115
FBXO28	hsa-miR-454-3p	95.5426	NM_001136115
FBXO28	hsa-miR-4465	95.2018	NM_001136115
FBXO28	hsa-miR-323a-3p	95.1111	NM_015176
FBXO28	hsa-miR-3140-3p	94.2468	NM_001136115
FBXO28	hsa-miR-4434	94.0709	NM_001136115
FBXO28	hsa-miR-5703	94.0709	NM_001136115
FBXO28	hsa-miR-376c-3p	93.7303	NM_015176
FBXO28	hsa-miR-301b-3p	93.6749	NM_001136115
FBXO28	hsa-miR-301a-3p	93.6749	NM_001136115
FBXO28	hsa-miR-130a-3p	93.6749	NM_001136115
FBXO28	hsa-miR-3666	93.6749	NM_001136115
FBXO28	hsa-miR-130b-3p	93.6749	NM_001136115
FBXO28	hsa-miR-4295	93.6749	NM_001136115
FBXO28	hsa-miR-32-3p	93.5245	NM_001136115
FBXO28	hsa-miR-651-3p	92.3903	NM_001136115
FBXO28	hsa-miR-195-3p	91.9848	NM_015176
FBXO28	hsa-miR-16-2-3p	91.9848	NM_015176
FBXO28	hsa-miR-5581-3p	91.1302	NM_001136115
FBXO28	hsa-miR-1323	90.4062	NM_001136115
FBXO28	hsa-miR-548o-3p	89.513	NM_001136115
FBXO28	hsa-miR-527	89.2432	NM_001136115
FBXO28	hsa-miR-518a-5p	89.2432	NM_001136115
FBXO28	hsa-miR-9-3p	89.2286	NM_001136115
FBXO28	hsa-miR-5688	89.041	NM_001136115
FBXO28	hsa-miR-335-5p	88.4748	NM_001136115
FBXO28	hsa-miR-1263	88.3344	NM_015176
FBXO28	hsa-miR-7154-3p	87.9812	NM_001136115
FBXO28	hsa-miR-373-5p	87.9482	NM_001136115
FBXO28	hsa-miR-616-5p	87.9482	NM_001136115
FBXO28	hsa-miR-371b-5p	87.9482	NM_001136115
FBXO28	hsa-miR-7-1-3p	87.6114	NM_001136115
FBXO28	hsa-miR-7-2-3p	87.6114	NM_001136115
FBXO28	hsa-miR-3664-3p	86.2514	NM_015176
FBXO28	hsa-miR-495-3p	85.2421	NM_001136115
FBXO28	hsa-miR-3145-5p	85.1362	NM_015176
FBXO28	hsa-miR-12131	85.0141	NM_001136115
FBXO28	hsa-miR-3121-3p	84.7121	NM_001136115
FBXO28	hsa-miR-5579-3p	84.4876	NM_015176
FBXO28	hsa-miR-6165	83.3485	NM_015176
FBXO28	hsa-miR-7-5p	83.2545	NM_001136115
FBXO28	hsa-miR-12127	82.3553	NM_001136115
FBXO28	hsa-miR-4521	82.0894	NM_001136115
FBXO28	hsa-miR-550b-3p	81.9243	NM_015176

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Motifs and transcription factors (TFs) regulating FBXO28

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FBXO28	metacluster_135.11	NR2C2 (directAnnotation).
FBXO28	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FBXO28	tfdimers__MD00038	TFAP2C (directAnnotation).
FBXO28	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
FBXO28	cisbp__M00968	MTF2 (directAnnotation).
FBXO28	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
FBXO28	metacluster_160.20	JUND; PRDM15 (directAnnotation).
FBXO28	cisbp__M00341	PAX6 (directAnnotation).
FBXO28	metacluster_198.3	ZFP64 (directAnnotation).
FBXO28	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
FBXO28	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
FBXO28	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
FBXO28	cisbp__M00788	ZFY (inferredBy_Orthology).
FBXO28	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
FBXO28	hdpi__ZNF304	ZNF304 (directAnnotation).
FBXO28	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
FBXO28	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
FBXO28	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
FBXO28	transfac_pro__M01199	TRIM28 (directAnnotation).
FBXO28	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
FBXO28	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
FBXO28	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
FBXO28	transfac_pro__M03806	ZBTB7C (directAnnotation).
FBXO28	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
FBXO28	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
FBXO28	transfac_pro__M02089	E2F3 (directAnnotation).
FBXO28	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
FBXO28	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
FBXO28	tfdimers__MD00483	ZBTB14 (directAnnotation).
FBXO28	cisbp__M07938	E2F1 (directAnnotation).
FBXO28	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
FBXO28	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
FBXO28	jaspar__MA1122.1	TFDP1 (directAnnotation).
FBXO28	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."