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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FBXO22

Summary for FBXO22

Gene information	Gene symbol	FBXO22
	Ensembl ID	ENSG00000167196
	Entrez ID	26263
	Gene name	F-box protein 22
	Synonyms	FBX22\|FISTC1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: FBXO22

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.3054	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.250389	0.00e+00

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Expression of FBXO22 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FBXO22

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FBXO22

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FBXO22	hsa-miR-4328	98.4218	NM_147188
FBXO22	hsa-miR-5011-5p	97.2254	NM_012170
FBXO22	hsa-miR-4261	96.8123	NM_012170
FBXO22	hsa-miR-30e-3p	96.7921	NM_147188
FBXO22	hsa-miR-30d-3p	96.7921	NM_147188
FBXO22	hsa-miR-30a-3p	96.7921	NM_147188
FBXO22	hsa-miR-7856-5p	96.0449	NM_147188
FBXO22	hsa-miR-147b-5p	95.5952	NM_012170
FBXO22	hsa-miR-4698	94.0098	NM_012170
FBXO22	hsa-miR-187-5p	93.4133	NM_147188
FBXO22	hsa-miR-548aa	93.219	NM_147188
FBXO22	hsa-miR-548ap-3p	93.219	NM_147188
FBXO22	hsa-miR-548t-3p	93.219	NM_147188
FBXO22	hsa-miR-12136	90.4283	NM_147188
FBXO22	hsa-miR-561-3p	90.3667	NM_147188
FBXO22	hsa-miR-190a-5p	90.3536	NM_012170
FBXO22	hsa-miR-190b-5p	90.3536	NM_012170
FBXO22	hsa-miR-1283	90.225	NM_012170
FBXO22	hsa-miR-6071	89.9308	NM_147188
FBXO22	hsa-miR-4776-3p	89.8293	NM_012170
FBXO22	hsa-miR-548ar-3p	89.3242	NM_147188
FBXO22	hsa-miR-7114-5p	88.9301	NM_012170
FBXO22	hsa-miR-496	87.9347	NM_147188
FBXO22	hsa-miR-4307	87.1473	NM_147188
FBXO22	hsa-miR-10524-5p	86.4445	NM_012170
FBXO22	hsa-miR-202-3p	86.4135	NM_147188
FBXO22	hsa-miR-4477b	85.741	NM_147188
FBXO22	hsa-miR-6828-3p	85.6554	NM_147188
FBXO22	hsa-miR-205-5p	85.5201	NM_147188
FBXO22	hsa-miR-4672	85.253	NM_147188
FBXO22	hsa-miR-548t-5p	85.0357	NM_147188
FBXO22	hsa-miR-548az-5p	85.0357	NM_147188
FBXO22	hsa-miR-802	84.9786	NM_012170
FBXO22	hsa-miR-190a-3p	84.344	NM_012170
FBXO22	hsa-miR-934	84.2453	NM_012170
FBXO22	hsa-miR-2054	83.964	NM_147188
FBXO22	hsa-miR-548bc	83.1746	NM_147188
FBXO22	hsa-miR-548f-3p	83.1746	NM_147188
FBXO22	hsa-miR-548a-3p	83.1746	NM_147188
FBXO22	hsa-miR-548az-3p	83.1746	NM_147188
FBXO22	hsa-miR-548e-3p	83.1746	NM_147188
FBXO22	hsa-miR-4729	82.4769	NM_147188
FBXO22	hsa-miR-548ab	82.4718	NM_147188
FBXO22	hsa-miR-548at-5p	81.9615	NM_147188
FBXO22	hsa-miR-4677-5p	81.4391	NM_147188
FBXO22	hsa-miR-4775	80.8317	NM_147188

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Motifs and transcription factors (TFs) regulating FBXO22

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FBXO22	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
FBXO22	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
FBXO22	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
FBXO22	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
FBXO22	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
FBXO22	jaspar__MA1933.1	SREBF2 (directAnnotation).
FBXO22	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
FBXO22	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
FBXO22	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
FBXO22	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
FBXO22	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
FBXO22	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
FBXO22	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."