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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FBXO21

Summary for FBXO21

Gene information	Gene symbol	FBXO21
	Ensembl ID	ENSG00000135108
	Entrez ID	23014
	Gene name	F-box protein 21
	Synonyms	FBX21\|KIAA0875
	Gene type	protein_coding
	UniProtAcc	O94952

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Dataset with differentially expressed gene: FBXO21

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.264227	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.40285	5.31e-42

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Expression of FBXO21 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FBXO21

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FBXO21

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FBXO21	hsa-miR-302c-5p	99.6877	NM_015002
FBXO21	hsa-miR-195-5p	98.9585	NM_015002
FBXO21	hsa-miR-15b-5p	98.9585	NM_015002
FBXO21	hsa-miR-16-5p	98.9585	NM_015002
FBXO21	hsa-miR-15a-5p	98.9585	NM_015002
FBXO21	hsa-miR-6838-5p	98.5745	NM_015002
FBXO21	hsa-miR-3143	98.5576	NM_033624
FBXO21	hsa-miR-8060	98.3306	NM_033624
FBXO21	hsa-miR-497-5p	98.0958	NM_015002
FBXO21	hsa-miR-424-5p	98.0958	NM_015002
FBXO21	hsa-miR-3191-5p	95.5123	NM_015002
FBXO21	hsa-miR-4531	95.4085	NM_015002
FBXO21	hsa-miR-4709-3p	94.3301	NM_033624
FBXO21	hsa-miR-651-3p	92.6171	NM_033624
FBXO21	hsa-miR-6758-3p	92.1944	NM_033624
FBXO21	hsa-miR-518c-5p	92.1564	NM_015002
FBXO21	hsa-miR-371b-3p	91.9818	NM_015002
FBXO21	hsa-let-7c-3p	91.6945	NM_033624
FBXO21	hsa-miR-4516	90.1131	NM_015002
FBXO21	hsa-miR-20a-5p	88.7075	NM_015002
FBXO21	hsa-miR-106b-5p	88.7075	NM_015002
FBXO21	hsa-miR-5703	88.3635	NM_015002
FBXO21	hsa-miR-4434	88.3635	NM_015002
FBXO21	hsa-miR-4280	88.1079	NM_015002
FBXO21	hsa-miR-769-5p	87.635	NM_033624
FBXO21	hsa-miR-380-3p	86.8103	NM_033624
FBXO21	hsa-miR-1256	85.5542	NM_033624
FBXO21	hsa-miR-579-3p	85.345	NM_033624
FBXO21	hsa-miR-664b-3p	85.345	NM_033624
FBXO21	hsa-miR-526b-3p	84.9579	NM_015002
FBXO21	hsa-miR-17-5p	84.9579	NM_015002
FBXO21	hsa-miR-519d-3p	84.9579	NM_015002
FBXO21	hsa-miR-106a-5p	84.9579	NM_015002
FBXO21	hsa-miR-20b-5p	84.9579	NM_015002
FBXO21	hsa-miR-93-5p	84.9579	NM_015002
FBXO21	hsa-miR-765	84.6863	NM_033624
FBXO21	hsa-miR-5696	83.911	NM_033624
FBXO21	hsa-miR-330-5p	82.1535	NM_015002
FBXO21	hsa-miR-11181-3p	80.8024	NM_033624
FBXO21	hsa-miR-326	80.7892	NM_015002

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Motifs and transcription factors (TFs) regulating FBXO21

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."