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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FBXO11

Summary for FBXO11

Gene information	Gene symbol	FBXO11
	Ensembl ID	ENSG00000138081
	Entrez ID	80204
	Gene name	F-box protein 11
	Synonyms	FBX11\|UBR6
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: FBXO11

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.560743	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.365294	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.252432	0.00e+00

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Expression of FBXO11 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FBXO11

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FBXO11

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FBXO11	hsa-miR-12124	99.6822	NM_001190274
FBXO11	hsa-miR-2681-5p	98.9011	NM_001190274
FBXO11	hsa-miR-548g-3p	98.8185	NM_001190274
FBXO11	hsa-miR-4747-5p	98.5154	NM_001190274
FBXO11	hsa-miR-5196-5p	98.5154	NM_001190274
FBXO11	hsa-miR-466	98.3786	NM_001190274
FBXO11	hsa-miR-1286	98.1247	NM_001190274
FBXO11	hsa-miR-130b-5p	97.1724	NM_001190274
FBXO11	hsa-miR-1287-5p	95.8326	NM_001190274
FBXO11	hsa-miR-1297	95.7438	NM_001190274
FBXO11	hsa-miR-323b-3p	94.9101	NM_001190274
FBXO11	hsa-miR-5047	94.654	NM_001190274
FBXO11	hsa-miR-1301-3p	94.654	NM_001190274
FBXO11	hsa-miR-26a-5p	94.4236	NM_001190274
FBXO11	hsa-miR-26b-5p	94.4236	NM_001190274
FBXO11	hsa-miR-3613-3p	94.3866	NM_001190274
FBXO11	hsa-miR-4427	94.1225	NM_001190274
FBXO11	hsa-miR-4722-5p	93.9962	NM_001190274
FBXO11	hsa-miR-4709-3p	93.9694	NM_001190274
FBXO11	hsa-miR-4789-3p	93.8363	NM_001190274
FBXO11	hsa-miR-1252-5p	93.679	NM_001190274
FBXO11	hsa-miR-4465	93.5426	NM_001190274
FBXO11	hsa-miR-548c-3p	93.5232	NM_001190274
FBXO11	hsa-miR-4738-3p	93.2898	NM_001190274
FBXO11	hsa-miR-3184-3p	92.874	NM_001190274
FBXO11	hsa-miR-5003-3p	92.0587	NM_001190274
FBXO11	hsa-miR-3671	92.034	NM_001190274
FBXO11	hsa-miR-1288-3p	91.8786	NM_001190274
FBXO11	hsa-miR-6782-5p	91.7867	NM_001190274
FBXO11	hsa-miR-5579-5p	91.524	NM_001190274
FBXO11	hsa-miR-4530	91.4517	NM_001190274
FBXO11	hsa-miR-1226-3p	91.3665	NM_001190274
FBXO11	hsa-miR-1244	90.6246	NM_001190274
FBXO11	hsa-miR-2052	90.4067	NM_001190274
FBXO11	hsa-miR-1263	90.2841	NM_001190274
FBXO11	hsa-miR-4672	90.2326	NM_001190274
FBXO11	hsa-miR-6787-3p	90.0688	NM_001190274
FBXO11	hsa-miR-4422	89.8563	NM_001190274
FBXO11	hsa-miR-3135b	89.778	NM_001190274
FBXO11	hsa-miR-9-3p	89.3386	NM_001190274
FBXO11	hsa-miR-4643	88.3787	NM_001190274
FBXO11	hsa-miR-4533	88.2384	NM_001190274
FBXO11	hsa-miR-4753-3p	88.1597	NM_001190274
FBXO11	hsa-miR-130a-5p	87.919	NM_001190274
FBXO11	hsa-miR-6809-3p	85.9902	NM_001190274
FBXO11	hsa-miR-4446-3p	85.58	NM_001190274
FBXO11	hsa-miR-5697	85.3345	NM_001190274
FBXO11	hsa-miR-9500	84.7218	NM_001190274
FBXO11	hsa-miR-150-3p	84.359	NM_001190274
FBXO11	hsa-miR-4666a-5p	83.6816	NM_001190274

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Motifs and transcription factors (TFs) regulating FBXO11

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FBXO11	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
FBXO11	jaspar__MA0502.2	NFYB (directAnnotation).
FBXO11	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
FBXO11	transfac_pro__M04918	EGR1 (directAnnotation).
FBXO11	metacluster_7.13	ZFX (directAnnotation).
FBXO11	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
FBXO11	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
FBXO11	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
FBXO11	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
FBXO11	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
FBXO11	cisbp__M00249	WT1 (directAnnotation).
FBXO11	cisbp__M01863	ZNF711 (inferredBy_Orthology).
FBXO11	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
FBXO11	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
FBXO11	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
FBXO11	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
FBXO11	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
FBXO11	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
FBXO11	jaspar__MA1721.1	ZNF93 (directAnnotation).
FBXO11	metacluster_151.2	ZNF23 (directAnnotation).
FBXO11	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
FBXO11	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
FBXO11	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
FBXO11	transfac_pro__M01199	TRIM28 (directAnnotation).
FBXO11	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
FBXO11	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
FBXO11	transfac_pro__M01253	CNOT3 (directAnnotation).
FBXO11	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
FBXO11	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
FBXO11	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
FBXO11	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
FBXO11	cisbp__M00968	MTF2 (directAnnotation).
FBXO11	metacluster_160.20	JUND; PRDM15 (directAnnotation).
FBXO11	swissregulon__hs__CHD1	CHD1 (directAnnotation).
FBXO11	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
FBXO11	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
FBXO11	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
FBXO11	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
FBXO11	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FBXO11	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
FBXO11	transfac_pro__M07310	SP5 (directAnnotation).
FBXO11	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
FBXO11	transfac_pro__M00938	E2F1 (directAnnotation).
FBXO11	transfac_pro__M04893	TAF1 (directAnnotation).
FBXO11	transfac_pro__M04817	ZBTB33 (directAnnotation).
FBXO11	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
FBXO11	transfac_pro__M12697	ZNF142 (directAnnotation).
FBXO11	metacluster_175.1	ZNF283 (directAnnotation).
FBXO11	cisbp__M00788	ZFY (inferredBy_Orthology).
FBXO11	tfdimers__MD00364	WT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."