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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FBXL5

Summary for FBXL5

Gene information	Gene symbol	FBXL5
	Ensembl ID	ENSG00000118564
	Entrez ID	26234
	Gene name	F-box and leucine rich repeat protein 5
	Synonyms	FBL4\|FBL5\|FLR1
	Gene type	protein_coding
	UniProtAcc	Q9UKA1

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Dataset with differentially expressed gene: FBXL5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.296936	7.51e-10
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.304787	7.54e-13

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Expression of FBXL5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FBXL5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FBXL5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FBXL5	hsa-miR-519b-3p	98.4809	NM_001193534
FBXL5	hsa-miR-519a-3p	98.4809	NM_001193534
FBXL5	hsa-miR-519c-3p	98.4809	NM_001193534
FBXL5	hsa-miR-106b-5p	97.7883	NM_001193534
FBXL5	hsa-miR-20a-5p	97.7883	NM_001193534
FBXL5	hsa-miR-106a-5p	97.3176	NM_001193534
FBXL5	hsa-miR-526b-3p	97.3176	NM_001193534
FBXL5	hsa-miR-17-5p	97.1316	NM_001193534
FBXL5	hsa-miR-93-5p	97.1316	NM_001193534
FBXL5	hsa-miR-20b-5p	97.1316	NM_001193534
FBXL5	hsa-miR-519d-3p	97.1316	NM_001193534
FBXL5	hsa-miR-4731-3p	96.8619	NM_001193534
FBXL5	hsa-miR-4801	96.8619	NM_001193534
FBXL5	hsa-miR-3973	96.111	NM_001193534
FBXL5	hsa-miR-4659a-3p	95.4172	NM_001193535
FBXL5	hsa-miR-4659b-3p	95.4172	NM_001193535
FBXL5	hsa-miR-9851-3p	94.0261	NM_001193535
FBXL5	hsa-miR-411-5p	93.9939	NM_001193534
FBXL5	hsa-miR-653-3p	93.4005	NM_001193535
FBXL5	hsa-miR-5003-5p	92.9748	NM_001193534
FBXL5	hsa-miR-651-3p	92.6181	NM_001193534
FBXL5	hsa-miR-4261	92.1843	NM_001193534
FBXL5	hsa-miR-6845-5p	90.9691	NM_001193535
FBXL5	hsa-miR-6762-5p	90.9691	NM_001193535
FBXL5	hsa-miR-12124	90.9152	NM_001193534
FBXL5	hsa-miR-6784-3p	90.7717	NM_001193535
FBXL5	hsa-miR-4796-3p	90.2396	NM_001193534
FBXL5	hsa-miR-150-5p	90.1954	NM_001193535
FBXL5	hsa-miR-6862-3p	89.9525	NM_001193535
FBXL5	hsa-miR-1227-5p	89.692	NM_001193535
FBXL5	hsa-miR-5585-5p	89.6327	NM_001193534
FBXL5	hsa-miR-548l	89.2962	NM_001193534
FBXL5	hsa-miR-147b-5p	88.1423	NM_001193534
FBXL5	hsa-miR-6787-3p	87.7356	NM_001193535
FBXL5	hsa-miR-1229-3p	87.6993	NM_001193535
FBXL5	hsa-miR-3609	87.5938	NM_001193534
FBXL5	hsa-miR-548ah-5p	87.5938	NM_001193534
FBXL5	hsa-miR-4422	87.4085	NM_001193535
FBXL5	hsa-miR-593-5p	86.6225	NM_001193535
FBXL5	hsa-miR-5696	86.2093	NM_001193535
FBXL5	hsa-miR-6875-3p	85.8454	NM_001193535
FBXL5	hsa-miR-488-3p	85.4235	NM_001193535
FBXL5	hsa-miR-589-5p	85.3546	NM_001193534
FBXL5	hsa-miR-548ax	84.9279	NM_001193534
FBXL5	hsa-miR-548ao-5p	84.9279	NM_001193534
FBXL5	hsa-miR-7845-5p	84.2049	NM_001193535
FBXL5	hsa-miR-4496	83.8176	NM_001193534
FBXL5	hsa-miR-95-5p	83.7316	NM_001193535
FBXL5	hsa-miR-374a-5p	83.0335	NM_001193535
FBXL5	hsa-miR-6507-3p	82.449	NM_001193534

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Motifs and transcription factors (TFs) regulating FBXL5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FBXL5	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
FBXL5	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
FBXL5	swissregulon__hs__CHD1	CHD1 (directAnnotation).
FBXL5	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FBXL5	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
FBXL5	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
FBXL5	transfac_pro__M12686	ZBTB10 (directAnnotation).
FBXL5	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
FBXL5	metacluster_143.14	ZNF320 (directAnnotation).
FBXL5	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
FBXL5	dbtfbs__ZBTB10_HEK293_ENCSR004PLU_merged_N1	ZBTB10 (directAnnotation).
FBXL5	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
FBXL5	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
FBXL5	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
FBXL5	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
FBXL5	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
FBXL5	kznf__ZNF141_Imbeault2017_RP_RCADE	ZNF141 (directAnnotation).
FBXL5	transfac_pro__M04617	ZBTB7A (directAnnotation).
FBXL5	transfac_pro__M01973	PLAG1 (directAnnotation).
FBXL5	metacluster_151.2	ZNF23 (directAnnotation).
FBXL5	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
FBXL5	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
FBXL5	metacluster_66.1	MTF1; ZNF320; ZNF320; ZNF320; ZNF782 (directAnnotation).
FBXL5	cisbp__M01864	EGR1 (inferredBy_Orthology).
FBXL5	tfdimers__MD00391	KLF4 (directAnnotation).
FBXL5	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
FBXL5	transfac_pro__M05479	ZNF580 (directAnnotation).
FBXL5	tfdimers__MD00151	CHURC1 (directAnnotation).
FBXL5	transfac_pro__M04817	ZBTB33 (directAnnotation).
FBXL5	cisbp__M00139	ZNF281 (inferredBy_Orthology).
FBXL5	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
FBXL5	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
FBXL5	transfac_public__M00491	PATZ1 (directAnnotation).
FBXL5	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
FBXL5	metacluster_3.10	KLF2; KLF4 (directAnnotation).
FBXL5	jaspar__MA1122.1	TFDP1 (directAnnotation).
FBXL5	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
FBXL5	transfac_pro__M01253	CNOT3 (directAnnotation).
FBXL5	metacluster_159.5	ZIC1; ZIC4; ZNF423 (directAnnotation). SP1 (inferredBy_Orthology).
FBXL5	cisbp__M00968	MTF2 (directAnnotation).
FBXL5	tfdimers__MD00038	TFAP2C (directAnnotation).
FBXL5	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
FBXL5	transfac_pro__M01199	TRIM28 (directAnnotation).
FBXL5	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
FBXL5	metacluster_3.14	WT1; WT1 (directAnnotation).
FBXL5	transfac_pro__M12697	ZNF142 (directAnnotation).
FBXL5	metacluster_84.2	RARA (directAnnotation).
FBXL5	transfac_pro__M01122	ZNF219 (directAnnotation).
FBXL5	transfac_pro__M07387	ZBTB7A (directAnnotation).
FBXL5	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."