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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: FBP1

Summary for FBP1

Gene information	Gene symbol	FBP1
	Ensembl ID	ENSG00000165140
	Entrez ID	2203
	Gene name	fructose-bisphosphatase 1
	Synonyms	FBP
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: FBP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	0.55159	3.89e-37
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.681256	2.18e-05
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.771562	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.962296	2.41e-12
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.384474	1.02e-17
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	-0.703746	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	1.60624	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	1.36563	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.767331	0.00e+00

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Expression of FBP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FBP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
FBP1	Regulation by the Disease Microenvironment

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MicroRNAs (miRNA) regulating FBP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FBP1	hsa-miR-6891-5p	93.5453	NM_000507
FBP1	hsa-miR-3173-3p	91.6965	NM_000507
FBP1	hsa-miR-12118	91.6965	NM_000507
FBP1	hsa-miR-7856-5p	89.7748	NM_000507
FBP1	hsa-miR-3059-3p	85.7749	NM_000507
FBP1	hsa-miR-4310	83.7236	NM_000507

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Motifs and transcription factors (TFs) regulating FBP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FBP1	metacluster_139.7	XBP1 (directAnnotation). XBP1 (inferredBy_Orthology).
FBP1	metacluster_173.2	ATF3; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; BATF3; CREB3; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L4; XBP1; XBP1; XBP1; XBP1 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM (inferredBy_Orthology).
FBP1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
FBP1	taipale_tf_pairs__CEBPG_CREB3L1_NGCCACGCAAYN_CAP_repr	CEBPG; CREB3L1 (directAnnotation).
FBP1	transfac_pro__M06516	ZNF418 (directAnnotation).
FBP1	jaspar__MA1125.1	ZNF384 (directAnnotation).
FBP1	transfac_pro__M05798	ZNF517 (directAnnotation).
FBP1	metacluster_151.2	ZNF23 (directAnnotation).
FBP1	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_2	SPIB; TEAD4 (directAnnotation).
FBP1	tfdimers__MD00554	CUX1; EP300 (directAnnotation).
FBP1	tfdimers__MD00438	E2F1; NKX3-2 (directAnnotation).
FBP1	metacluster_70.16	POU5F1; POU5F1 (directAnnotation).
FBP1	transfac_pro__M06642	ZSCAN10 (directAnnotation).
FBP1	transfac_pro__M05612	ZNF189 (directAnnotation).
FBP1	transfac_pro__M06334	ZNF782 (directAnnotation).
FBP1	transfac_pro__M06267	ZNF805 (directAnnotation).
FBP1	metacluster_31.7	FOXO1; FOXO3; FOXO6 (directAnnotation).
FBP1	tfdimers__MD00330	FOXP3; HSF1 (directAnnotation).
FBP1	metacluster_29.4	BCL6; BCL6; BCL6; BCL6; BCL6B; BCL6B; BCL6B; BCL6B; BCL6B (directAnnotation). BCL6; BCL6; BCL6 (inferredBy_Orthology).
FBP1	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).
FBP1	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
FBP1	transfac_pro__M06313	ZNF678 (directAnnotation).
FBP1	metacluster_31.6	ZNF569 (directAnnotation). ZNF569 (inferredBy_Orthology).
FBP1	hdpi__ZBED1	ZBED1 (directAnnotation).
FBP1	transfac_pro__M06192	ZNF135 (directAnnotation).
FBP1	tfdimers__MD00404	FOXA1; FOXA2; FOXA3; FOXP3 (directAnnotation).
FBP1	transfac_pro__M06085	ZNF26 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
FBP1	"2,5-Anhydroglucitol-1,6-Biphosphate"	DB02778	small molecule
FBP1	"2,5-DICHLORO-N-(5-CHLORO-1,3-BENZOXAZOL-2-YL)BENZENESULFONAMIDE"	DB07312	small molecule
FBP1	"2,5-DICHLORO-N-[5-METHOXY-7-(6-METHOXYPYRIDIN-3-YL)-1,3-BENZOXAZOL-2-YL]BENZENESULFONAMIDE"	DB07321	small molecule
FBP1	"4-AMINO-N-[(2-SULFANYLETHYL)CARBAMOYL]BENZENESULFONAMIDE"	DB08484	small molecule
FBP1	"Adenosine phosphate"	DB00131	small molecule
FBP1	"Fructose-6-phosphate"	DB04493	small molecule
FBP1	"Managlinat dialanetil"	DB05518	small molecule
FBP1	"MB-07803"	DB05053	small molecule
FBP1	"Mdl-29951"	DB04175	small molecule
FBP1	"N-[7-(3-AMINOPHENYL)-5-METHOXY-1,3-BENZOXAZOL-2-YL]-2,5-DICHLOROBENZENESULFONAMIDE"	DB07270	small molecule
FBP1	"{4-[3-(6,7-Diethoxy-Quinazolin-4-Ylamino)-Phenyl]-Thiazol-2-Yl}-Methanol"	DB02848	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."