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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAXC

Summary for FAXC

Gene information	Gene symbol	FAXC
	Ensembl ID	ENSG00000146267
	Entrez ID	84553
	Gene name	failed axon connections homolog, metaxin like GST domain containing
	Synonyms	C6orf168\|dJ273F20\|MGC2817
	Gene type	protein_coding
	UniProtAcc	Q5TGI0

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Dataset with differentially expressed gene: FAXC

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.339322	0.00e+00

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Expression of FAXC in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAXC

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAXC

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAXC	hsa-let-7c-3p	99.1918	NM_032511
FAXC	hsa-miR-570-3p	97.447	NM_032511
FAXC	hsa-miR-204-3p	96.6165	NM_032511
FAXC	hsa-miR-4646-5p	96.5987	NM_032511
FAXC	hsa-miR-6074	96.0183	NM_032511
FAXC	hsa-miR-876-5p	94.6177	NM_032511
FAXC	hsa-miR-5192	93.0173	NM_032511
FAXC	hsa-miR-3680-3p	92.9147	NM_032511
FAXC	hsa-miR-4790-3p	92.5237	NM_032511
FAXC	hsa-miR-8068	92.4183	NM_032511
FAXC	hsa-miR-1250-3p	92.2918	NM_032511
FAXC	hsa-miR-3167	90.8709	NM_032511
FAXC	hsa-miR-3529-3p	90.7647	NM_032511
FAXC	hsa-miR-450b-5p	90.5515	NM_032511
FAXC	hsa-miR-1305	90.5121	NM_032511
FAXC	hsa-miR-1251-3p	90.3973	NM_032511
FAXC	hsa-miR-551b-5p	90.0247	NM_032511
FAXC	hsa-miR-4500	89.9055	NM_032511
FAXC	hsa-miR-576-5p	89.4476	NM_032511
FAXC	hsa-miR-5580-3p	89.261	NM_032511
FAXC	hsa-miR-6739-5p	89.1537	NM_032511
FAXC	hsa-miR-6733-5p	89.1537	NM_032511
FAXC	hsa-miR-3671	88.8998	NM_032511
FAXC	hsa-miR-6514-3p	88.897	NM_032511
FAXC	hsa-let-7a-2-3p	88.8032	NM_032511
FAXC	hsa-let-7g-3p	88.8032	NM_032511
FAXC	hsa-miR-4662a-3p	88.7371	NM_032511
FAXC	hsa-miR-493-5p	88.2591	NM_032511
FAXC	hsa-miR-4762-5p	88.1381	NM_032511
FAXC	hsa-miR-4458	87.7731	NM_032511
FAXC	hsa-miR-3065-5p	87.7527	NM_032511
FAXC	hsa-miR-3692-3p	87.193	NM_032511
FAXC	hsa-miR-4640-5p	87.0601	NM_032511
FAXC	hsa-miR-3064-3p	86.8981	NM_032511
FAXC	hsa-miR-1290	86.8935	NM_032511
FAXC	hsa-let-7e-5p	86.8375	NM_032511
FAXC	hsa-let-7g-5p	86.8375	NM_032511
FAXC	hsa-let-7f-5p	86.8375	NM_032511
FAXC	hsa-let-7c-5p	86.8375	NM_032511
FAXC	hsa-miR-98-5p	86.8375	NM_032511
FAXC	hsa-let-7i-5p	86.8375	NM_032511
FAXC	hsa-let-7b-5p	86.8375	NM_032511
FAXC	hsa-let-7a-5p	86.8375	NM_032511
FAXC	hsa-miR-7-1-3p	86.7288	NM_032511
FAXC	hsa-miR-7-2-3p	86.7288	NM_032511
FAXC	hsa-miR-520f-5p	86.3103	NM_032511
FAXC	hsa-miR-411-3p	86.2335	NM_032511
FAXC	hsa-miR-379-3p	86.2335	NM_032511
FAXC	hsa-miR-3153	85.8481	NM_032511
FAXC	hsa-miR-126-5p	85.8317	NM_032511

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Motifs and transcription factors (TFs) regulating FAXC

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAXC	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
FAXC	cisbp__M00808	MYPOP (inferredBy_Orthology).
FAXC	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."