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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FASLG

Summary for FASLG

Gene information	Gene symbol	FASLG
	Ensembl ID	ENSG00000117560
	Entrez ID	356
	Gene name	Fas ligand
	Synonyms	APT1LG1\|CD178\|FasL\|TNFSF6
	Gene type	protein_coding
	UniProtAcc	P48023

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Dataset with differentially expressed gene: FASLG

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	0.359781	1.06e-33
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.465914	1.15e-20

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Expression of FASLG in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FASLG

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
FASLG	NK cells	CPI-SS0D168412F	FASLG_FAS	FASLG	FAS	False	NK cells	CD4+ T cells	GSE169246_PacAteTissue	pre	resistant
FASLG	NK cells	CPI-SS0D168412F	FASLG_FAS	FASLG	FAS	False	NK cells	CD8+ T cells	GSE169246_PacAteTissue	pre	resistant
FASLG	CD8+ T cells	CPI-SS0D168412F	FASLG_FAS	FASLG	FAS	False	CD8+ T cells	CD4+ T cells	GSE207422_Sin	post	resistant
FASLG	CD8+ T cells	CPI-SS0D168412F	FASLG_FAS	FASLG	FAS	False	CD8+ T cells	CD8+ T cells	GSE207422_Sin	post	resistant
FASLG	CD8+ T cells	CPI-SS0D168412F	FASLG_FAS	FASLG	FAS	False	CD8+ T cells	Fibroblasts	GSE207422_Sin	post	resistant
FASLG	CD8+ T cells	CPI-SS0D168412F	FASLG_FAS	FASLG	FAS	False	CD8+ T cells	Neutrophils	GSE207422_Sin	post	resistant
FASLG	CD8+ T cells	CPI-SS0D168412F	FASLG_FAS	FASLG	FAS	False	NK cells	CD8+ T cells	GSE207422_Sin	post	resistant
FASLG	CD8+ T cells	CPI-SS0D168412F	FASLG_FAS	FASLG	FAS	False	CD8+ T cells	CD4+ T cells	GSE207422_Sin	post	sensitive
FASLG	CD8+ T cells	CPI-SS0D168412F	FASLG_FAS	FASLG	FAS	False	CD8+ T cells	CD8+ T cells	GSE207422_Sin	post	sensitive
FASLG	CD8+ T cells	CPI-SS0D168412F	FASLG_FAS	FASLG	FAS	False	CD8+ T cells	Mono/Macro	GSE207422_Sin	post	sensitive
FASLG	CD8+ T cells	CPI-SS0D168412F	FASLG_FAS	FASLG	FAS	False	CD8+ T cells	Neutrophils	GSE207422_Sin	post	sensitive
FASLG	CD8+ T cells	CPI-SS0D168412F	FASLG_FAS	FASLG	FAS	False	NK cells	CD8+ T cells	GSE207422_Sin	post	sensitive

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FASLG

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FASLG	hsa-miR-8485	99.8067	NM_000639
FASLG	hsa-miR-21-5p	98.9344	NM_001302746
FASLG	hsa-miR-590-5p	98.359	NM_001302746
FASLG	hsa-miR-6873-3p	91.4045	NM_000639
FASLG	hsa-miR-105-5p	91.1822	NM_000639
FASLG	hsa-miR-7853-5p	91.1822	NM_000639
FASLG	hsa-miR-149-5p	90.0516	NM_000639
FASLG	hsa-miR-5579-3p	87.9535	NM_001302746
FASLG	hsa-miR-4424	87.6481	NM_000639
FASLG	hsa-miR-6740-3p	87.4532	NM_001302746
FASLG	hsa-miR-1258	87.4419	NM_000639
FASLG	hsa-miR-12129	86.9752	NM_000639
FASLG	hsa-miR-6514-3p	86.8738	NM_001302746
FASLG	hsa-miR-214-5p	85.4018	NM_001302746
FASLG	hsa-let-7g-5p	84.7578	NM_001302746
FASLG	hsa-let-7a-5p	84.7578	NM_001302746
FASLG	hsa-let-7f-5p	84.7578	NM_001302746
FASLG	hsa-miR-4500	84.7578	NM_001302746
FASLG	hsa-let-7c-5p	84.7578	NM_001302746
FASLG	hsa-let-7b-5p	84.7578	NM_001302746
FASLG	hsa-let-7e-5p	84.7578	NM_001302746
FASLG	hsa-let-7i-5p	84.7578	NM_001302746
FASLG	hsa-miR-98-5p	84.7578	NM_001302746
FASLG	hsa-miR-4269	84.2938	NM_000639
FASLG	hsa-miR-6715b-5p	84.2938	NM_000639
FASLG	hsa-miR-219a-1-3p	83.5553	NM_001302746
FASLG	hsa-miR-670-3p	83.2044	NM_001302746
FASLG	hsa-miR-586	83.0872	NM_000639
FASLG	hsa-miR-24-3p	82.5729	NM_001302746
FASLG	hsa-miR-4474-3p	82.2107	NM_001302746
FASLG	hsa-miR-4503	82.0467	NM_000639
FASLG	hsa-miR-4458	81.3658	NM_001302746
FASLG	hsa-let-7d-5p	81.3658	NM_001302746
FASLG	hsa-miR-6811-3p	80.1719	NM_001302746
FASLG	hsa-miR-659-5p	80.0314	NM_001302746

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Motifs and transcription factors (TFs) regulating FASLG

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FASLG	transfac_pro__M00805	LEF1; TCF7; TCF7L1 (directAnnotation).
FASLG	cisbp__M00767	ZSCAN10 (inferredBy_Orthology).
FASLG	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
FASLG	metacluster_22.13	MAFK (inferredBy_Orthology).
FASLG	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
FASLG	metacluster_22.32	NFE2L2 (directAnnotation).
FASLG	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
FASLG	metacluster_22.29	NFE2 (directAnnotation).
FASLG	metacluster_22.25	NFE2L2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."