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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAS

Summary for FAS

Gene information	Gene symbol	FAS
	Ensembl ID	ENSG00000026103
	Entrez ID	355
	Gene name	Fas cell surface death receptor
	Synonyms	APO-1\|APT1\|CD95\|FAS1\|TNFRSF6
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: FAS

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.460018	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.483589	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.269719	3.18e-09
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.324012	6.04e-03

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Expression of FAS in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAS

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAS

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAS	hsa-miR-3605-5p	96.2776	NM_152872
FAS	hsa-miR-431-5p	96.1613	NM_001320619
FAS	hsa-miR-192-3p	94.2231	NM_001320619
FAS	hsa-miR-5704	90.448	NM_152871
FAS	hsa-miR-513c-3p	89.2869	NM_152871
FAS	hsa-miR-513a-3p	89.2869	NM_152871
FAS	hsa-miR-3606-3p	88.5535	NM_152871
FAS	hsa-miR-7160-5p	88.2663	NM_152871
FAS	hsa-miR-4786-3p	87.9075	NM_001320619
FAS	hsa-miR-24-3p	85.9197	NM_152871
FAS	hsa-miR-3121-3p	84.8259	NM_152871
FAS	hsa-miR-6866-5p	84.5828	NM_152871
FAS	hsa-miR-23b-3p	83.0277	NM_001320619
FAS	hsa-miR-23c	83.0277	NM_001320619
FAS	hsa-miR-23a-3p	83.0277	NM_001320619
FAS	hsa-miR-766-3p	82.9281	NM_152872
FAS	hsa-miR-4257	82.7686	NM_152871
FAS	hsa-miR-625-5p	81.7857	NM_152871
FAS	hsa-miR-3119	81.6331	NM_152872
FAS	hsa-miR-5001-3p	81.355	NM_152871
FAS	hsa-miR-338-3p	80.7263	NM_001320619
FAS	hsa-miR-3191-5p	80.328	NM_001320619
FAS	hsa-miR-106b-5p	80.2706	NM_152871
FAS	hsa-miR-20a-5p	80.2706	NM_152871
FAS	hsa-miR-517-5p	80.079	NM_152872

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Motifs and transcription factors (TFs) regulating FAS

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAS	tfdimers__MD00147	ELF5; TFAP2C (directAnnotation).
FAS	jaspar__MA1952.1	FOXJ2 (directAnnotation).
FAS	metacluster_2.6	IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).
FAS	kznf__ZNF200_Najafabadi2015_ChIP-seq	ZNF200 (directAnnotation).
FAS	swissregulon__mm__Elf3	ELF3 (inferredBy_Orthology).
FAS	kznf__ZNF555_Imbeault2017_RP_ChIP-seq	ZNF555 (directAnnotation).
FAS	transfac_pro__M06282	ZSCAN10 (inferredBy_Orthology).
FAS	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
FAS	transfac_pro__M00801	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM (directAnnotation). ATF7-NPFF (inferredBy_Orthology).
FAS	metacluster_148.1	ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6; ATF6B; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB3; CREB3; CREB5; CREB5; CREB5; CREM; CREM; FOS; FOS; FOSB; FOSB; FOSB; FOSL1; JDP2; JDP2; JUN; JUN; JUN; JUNB; JUND; MAF; MAF; MAFA; MAFA; MAFF; MAFF; MAFF; MAFF; MAFG; MAFG; ZBTB21 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM; JDP2; JUN; JUNB; JUND; MAFB (inferredBy_Orthology).
FAS	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
FAS	transfac_pro__M02089	E2F3 (directAnnotation).
FAS	metacluster_180.3	ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6B; ATF7; ATF7; BACH2; BATF3; BATF3; CREB1; CREB1; CREB3; FOSL1; FOSL2; JDP2; JUN; JUN; JUN; JUND; JUND; XBP1; ZBTB21 (directAnnotation). JDP2; JDP2; JUND (inferredBy_Orthology).
FAS	transfac_pro__M07436	WT1 (directAnnotation).
FAS	hdpi__NRL	NRL (directAnnotation).
FAS	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
FAS	transfac_pro__M04817	ZBTB33 (directAnnotation).
FAS	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
FAS	transfac_pro__M01199	TRIM28 (directAnnotation).
FAS	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
FAS	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
FAS	transfac_pro__M07329	SP7 (directAnnotation).
FAS	transfac_pro__M00938	E2F1 (directAnnotation).
FAS	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
FAS	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
FAS	metacluster_3.14	WT1; WT1 (directAnnotation).
FAS	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
FAS	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
FAS	transfac_pro__M00716	ZBTB14 (directAnnotation).
FAS	cisbp__M07938	E2F1 (directAnnotation).
FAS	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
FAS	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
FAS	transfac_pro__M07310	SP5 (directAnnotation).
FAS	transfac_pro__M02092	EGR2 (directAnnotation).
FAS	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
FAS	jaspar__MA1122.1	TFDP1 (directAnnotation).
FAS	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
FAS	hdpi__RARA	RARA (directAnnotation).
FAS	transfac_pro__M04893	TAF1 (directAnnotation).
FAS	hocomoco__FEV_HUMAN.H11MO.0.B	FEV (directAnnotation).
FAS	hdpi__HIP2	UBE2K (directAnnotation).
FAS	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
FAS	hdpi__PDLIM5	PDLIM5 (directAnnotation).
FAS	hdpi__HTATIP2	HTATIP2 (directAnnotation).
FAS	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
FAS	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
FAS	hdpi__OTUD4	OTUD4 (directAnnotation).
FAS	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
FAS	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."