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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FARP1

Summary for FARP1

Gene information	Gene symbol	FARP1
	Ensembl ID	ENSG00000152767
	Entrez ID	10160
	Gene name	FERM, ARH/RhoGEF and pleckstrin domain protein 1
	Synonyms	CDEP\|GLCC1\|MGC87400\|PLEKHC2\|PPP1R75
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: FARP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.263678	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.369118	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.26915	1.16e-36

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Expression of FARP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FARP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FARP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FARP1	hsa-miR-1324	93.3932	NM_005766
FARP1	hsa-miR-548x-3p	93.3637	NM_001001715
FARP1	hsa-miR-548aj-3p	93.3637	NM_001001715
FARP1	hsa-miR-4430	93.107	NM_001001715
FARP1	hsa-miR-3652	93.107	NM_001001715
FARP1	hsa-miR-96-5p	91.535	NM_005766
FARP1	hsa-miR-4499	91.4899	NM_005766
FARP1	hsa-miR-211-5p	90.8142	NM_005766
FARP1	hsa-miR-204-5p	90.8142	NM_005766
FARP1	hsa-miR-6797-5p	90.7794	NM_005766
FARP1	hsa-miR-1249-5p	90.7794	NM_005766
FARP1	hsa-miR-548ae-3p	89.622	NM_001001715
FARP1	hsa-miR-548j-3p	89.622	NM_001001715
FARP1	hsa-miR-548am-3p	89.622	NM_001001715
FARP1	hsa-miR-548ah-3p	89.622	NM_001001715
FARP1	hsa-miR-548aq-3p	89.622	NM_001001715
FARP1	hsa-miR-4695-3p	88.8197	NM_005766
FARP1	hsa-miR-1271-5p	88.7639	NM_005766
FARP1	hsa-miR-12133	88.7639	NM_005766
FARP1	hsa-miR-3978	87.2884	NM_005766
FARP1	hsa-miR-6715b-3p	87.228	NM_005766
FARP1	hsa-miR-3662	87.1705	NM_005766
FARP1	hsa-miR-3938	87.0204	NM_005766
FARP1	hsa-miR-6832-3p	86.8965	NM_005766
FARP1	hsa-miR-1294	86.7918	NM_005766
FARP1	hsa-miR-9986	86.7918	NM_005766
FARP1	hsa-miR-6887-5p	86.6725	NM_005766
FARP1	hsa-miR-6795-5p	86.6725	NM_005766
FARP1	hsa-miR-4678	86.4251	NM_005766
FARP1	hsa-miR-506-3p	85.9734	NM_005766
FARP1	hsa-miR-124-3p	85.9734	NM_005766
FARP1	hsa-miR-4524b-3p	85.7906	NM_005766
FARP1	hsa-miR-1183	85.5073	NM_001001715
FARP1	hsa-miR-200c-3p	85.134	NM_005766
FARP1	hsa-miR-429	85.134	NM_005766
FARP1	hsa-miR-200b-3p	85.134	NM_005766
FARP1	hsa-miR-6892-3p	85.12	NM_001001715
FARP1	hsa-miR-3910	84.4476	NM_005766
FARP1	hsa-miR-3714	84.4476	NM_005766
FARP1	hsa-miR-548u	82.671	NM_005766
FARP1	hsa-miR-7161-5p	82.671	NM_005766
FARP1	hsa-miR-19a-5p	81.24	NM_005766
FARP1	hsa-miR-19b-1-5p	81.24	NM_005766
FARP1	hsa-miR-19b-2-5p	81.24	NM_005766
FARP1	hsa-miR-3152-5p	80.2583	NM_005766
FARP1	hsa-miR-4774-3p	80.2583	NM_005766

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Motifs and transcription factors (TFs) regulating FARP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FARP1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
FARP1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
FARP1	hdpi__ETV4	ETV4 (directAnnotation).
FARP1	cisbp__M02645	ETS1 (directAnnotation).
FARP1	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
FARP1	taipale_tf_pairs__ETV2_TCF3_CASSTGNNCCGGAWRYN_CAP_repr	ETV2; TCF3 (directAnnotation).
FARP1	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
FARP1	cisbp__M00808	MYPOP (inferredBy_Orthology).
FARP1	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
FARP1	kznf__PRDM1_modENCODE.2_ChIP-seq	PRDM1 (directAnnotation).
FARP1	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
FARP1	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
FARP1	metacluster_52.11	ZNF184 (directAnnotation).
FARP1	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
FARP1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
FARP1	jaspar__MA1933.1	SREBF2 (directAnnotation).
FARP1	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
FARP1	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
FARP1	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."