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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM8A1

Summary for FAM8A1

Gene information	Gene symbol	FAM8A1
	Ensembl ID	ENSG00000137414
	Entrez ID	51439
	Gene name	family with sequence similarity 8 member A1
	Synonyms	AHCP
	Gene type	protein_coding
	UniProtAcc	Q9UBU6

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Dataset with differentially expressed gene: FAM8A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.272851	1.12e-16

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Expression of FAM8A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM8A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM8A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM8A1	hsa-miR-429	98.522	NM_016255
FAM8A1	hsa-miR-200c-3p	98.522	NM_016255
FAM8A1	hsa-miR-200b-3p	98.522	NM_016255
FAM8A1	hsa-miR-590-3p	98.0672	NM_016255
FAM8A1	hsa-miR-452-5p	97.723	NM_016255
FAM8A1	hsa-miR-4676-3p	96.5716	NM_016255
FAM8A1	hsa-miR-892c-3p	96.5716	NM_016255
FAM8A1	hsa-miR-4775	96.3234	NM_016255
FAM8A1	hsa-miR-570-3p	94.3487	NM_016255
FAM8A1	hsa-miR-122b-5p	92.6171	NM_016255
FAM8A1	hsa-miR-3163	91.7205	NM_016255
FAM8A1	hsa-miR-9-5p	91.3725	NM_016255
FAM8A1	hsa-miR-3121-3p	91.0308	NM_016255
FAM8A1	hsa-miR-5011-5p	90.6939	NM_016255
FAM8A1	hsa-miR-7161-3p	88.8457	NM_016255
FAM8A1	hsa-miR-633	88.1807	NM_016255
FAM8A1	hsa-miR-6511a-5p	88.0922	NM_016255
FAM8A1	hsa-miR-1910-3p	88.0922	NM_016255
FAM8A1	hsa-miR-1297	87.8888	NM_016255
FAM8A1	hsa-miR-6823-5p	87.1575	NM_016255
FAM8A1	hsa-miR-372-5p	86.8011	NM_016255
FAM8A1	hsa-miR-126-5p	86.4241	NM_016255
FAM8A1	hsa-miR-944	85.8238	NM_016255
FAM8A1	hsa-miR-4999-5p	85.8178	NM_016255
FAM8A1	hsa-miR-7112-3p	85.6627	NM_016255
FAM8A1	hsa-miR-2355-5p	85.6428	NM_016255
FAM8A1	hsa-miR-514a-3p	85.2074	NM_016255
FAM8A1	hsa-miR-514b-3p	85.2074	NM_016255
FAM8A1	hsa-miR-6507-5p	85.1229	NM_016255
FAM8A1	hsa-miR-32-3p	84.3531	NM_016255
FAM8A1	hsa-miR-3977	83.5701	NM_016255
FAM8A1	hsa-miR-7154-5p	83.5167	NM_016255
FAM8A1	hsa-miR-3658	83.4384	NM_016255
FAM8A1	hsa-miR-17-3p	81.6952	NM_016255
FAM8A1	hsa-miR-421	81.6195	NM_016255
FAM8A1	hsa-miR-26a-5p	80.6992	NM_016255
FAM8A1	hsa-miR-26b-5p	80.6992	NM_016255

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Motifs and transcription factors (TFs) regulating FAM8A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM8A1	metacluster_132.4	MEF2B; MEF2B; MEF2B; MEF2B; MEF2C; MEF2C; MEF2D; MEF2D; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF (directAnnotation). SRF; SRF; SRF; SRF (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."