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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM89A

Summary for FAM89A

Gene information	Gene symbol	FAM89A
	Ensembl ID	ENSG00000182118
	Entrez ID	375061
	Gene name	family with sequence similarity 89 member A
	Synonyms	C1orf153\|MGC15887
	Gene type	protein_coding
	UniProtAcc	Q96GI7

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Dataset with differentially expressed gene: FAM89A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.857453	3.81e-05
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.308701	4.68e-06
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.310917	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.454782	0.00e+00

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Expression of FAM89A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM89A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM89A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM89A	hsa-miR-9903	93.4285	NM_198552
FAM89A	hsa-miR-876-3p	89.0642	NM_198552
FAM89A	hsa-miR-548l	88.2879	NM_198552
FAM89A	hsa-miR-7156-5p	87.4538	NM_198552
FAM89A	hsa-miR-4273	87.4538	NM_198552
FAM89A	hsa-miR-3163	86.0755	NM_198552
FAM89A	hsa-miR-16-5p	82.259	NM_198552
FAM89A	hsa-miR-424-5p	82.259	NM_198552
FAM89A	hsa-miR-497-5p	82.259	NM_198552
FAM89A	hsa-miR-195-5p	82.259	NM_198552
FAM89A	hsa-miR-6838-5p	82.259	NM_198552
FAM89A	hsa-miR-15b-5p	82.259	NM_198552
FAM89A	hsa-miR-15a-5p	82.259	NM_198552
FAM89A	hsa-miR-6728-5p	80.3656	NM_198552

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Motifs and transcription factors (TFs) regulating FAM89A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM89A	metacluster_7.13	ZFX (directAnnotation).
FAM89A	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
FAM89A	transfac_pro__M05479	ZNF580 (directAnnotation).
FAM89A	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
FAM89A	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
FAM89A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
FAM89A	hdpi__ETV4	ETV4 (directAnnotation).
FAM89A	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
FAM89A	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
FAM89A	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FAM89A	jaspar__MA0079.5	SP1 (directAnnotation).
FAM89A	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
FAM89A	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
FAM89A	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
FAM89A	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
FAM89A	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
FAM89A	metacluster_3.14	WT1; WT1 (directAnnotation).
FAM89A	cisbp__M07938	E2F1 (directAnnotation).
FAM89A	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
FAM89A	transfac_pro__M04617	ZBTB7A (directAnnotation).
FAM89A	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
FAM89A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
FAM89A	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
FAM89A	transfac_pro__M07387	ZBTB7A (directAnnotation).
FAM89A	transfac_pro__M07436	WT1 (directAnnotation).
FAM89A	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
FAM89A	transfac_pro__M00716	ZBTB14 (directAnnotation).
FAM89A	swissregulon__hs__CHD1	CHD1 (directAnnotation).
FAM89A	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
FAM89A	transfac_pro__M04893	TAF1 (directAnnotation).
FAM89A	transfac_pro__M03876	ZBTB33 (directAnnotation).
FAM89A	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
FAM89A	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
FAM89A	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
FAM89A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
FAM89A	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
FAM89A	transfac_pro__M05908	ZNF319 (inferredBy_Orthology).
FAM89A	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."