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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM83A

Summary for FAM83A

Gene information	Gene symbol	FAM83A
	Ensembl ID	ENSG00000147689
	Entrez ID	84985
	Gene name	family with sequence similarity 83 member A
	Synonyms	BJ-TSA-9\|MGC14128
	Gene type	protein_coding
	UniProtAcc	Q86UY5

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Dataset with differentially expressed gene: FAM83A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.490353	1.26e-02
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.440065	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.315206	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.613872	1.07e-35

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Expression of FAM83A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM83A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM83A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM83A	hsa-miR-196a-1-3p	92.1802	NM_207006
FAM83A	hsa-miR-873-5p	91.4165	NM_032899
FAM83A	hsa-miR-449a	87.7126	NM_032899
FAM83A	hsa-miR-34a-5p	87.7126	NM_032899
FAM83A	hsa-miR-4297	86.3355	NM_001288587
FAM83A	hsa-miR-766-5p	83.9543	NM_032899
FAM83A	hsa-miR-34c-5p	83.8996	NM_032899
FAM83A	hsa-miR-449b-5p	83.8996	NM_032899
FAM83A	hsa-miR-6773-5p	83.5788	NM_032899
FAM83A	hsa-miR-6828-3p	82.1625	NM_001288587
FAM83A	hsa-miR-12118	80.7151	NM_032899
FAM83A	hsa-miR-3173-3p	80.7151	NM_032899

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Motifs and transcription factors (TFs) regulating FAM83A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM83A	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
FAM83A	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
FAM83A	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
FAM83A	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
FAM83A	transfac_pro__M01968	FOXO1 (directAnnotation).
FAM83A	homer__GKTAATGR_Nkx6.1	NKX6-1 (inferredBy_Orthology).
FAM83A	metacluster_22.28	BACH1 (directAnnotation).
FAM83A	metacluster_51.10	HOXA5 (directAnnotation).
FAM83A	metacluster_161.16	NKX3-2 (directAnnotation).
FAM83A	metacluster_51.30	HOXB7 (directAnnotation).
FAM83A	metacluster_51.12	PDX1 (directAnnotation).
FAM83A	hocomoco__PDX1_MOUSE.H11MO.0.B	PDX1 (inferredBy_Orthology).
FAM83A	metacluster_51.22	MEOX1 (directAnnotation).
FAM83A	metacluster_51.7	VAX1 (directAnnotation).
FAM83A	metacluster_51.8	HOXB2 (directAnnotation).
FAM83A	metacluster_51.9	HOXA2 (directAnnotation).
FAM83A	metacluster_51.17	HOXB5 (directAnnotation).
FAM83A	taipale_tf_pairs__HOXA4_RTMATTAN_HT	HOXA4 (directAnnotation).
FAM83A	taipale_cyt_meth__LMX1B_CTCGTTAW_FL_meth	LMX1B (directAnnotation).
FAM83A	jaspar__MA0707.2	MNX1 (directAnnotation).
FAM83A	metacluster_51.29	HOXD8 (directAnnotation).
FAM83A	metacluster_51.15	HOXA5 (directAnnotation).
FAM83A	metacluster_51.19	HOXD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."