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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM53C

Summary for FAM53C

Gene information	Gene symbol	FAM53C
	Ensembl ID	ENSG00000120709
	Entrez ID	51307
	Gene name	family with sequence similarity 53 member C
	Synonyms	C5orf6
	Gene type	protein_coding
	UniProtAcc	Q9NYF3

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Dataset with differentially expressed gene: FAM53C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.500227	0.00e+00

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Expression of FAM53C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM53C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM53C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM53C	hsa-miR-1246	98.5425	NM_001135647
FAM53C	hsa-miR-6734-3p	96.8075	NM_001135647
FAM53C	hsa-miR-7976	95.5832	NM_001135647
FAM53C	hsa-miR-3121-5p	94.3373	NM_001135647
FAM53C	hsa-miR-4267	93.5775	NM_001135647
FAM53C	hsa-miR-6852-5p	93.1999	NM_001135647
FAM53C	hsa-miR-3667-3p	92.5042	NM_001135647
FAM53C	hsa-miR-185-3p	91.8946	NM_001135647
FAM53C	hsa-miR-4436b-5p	91.5354	NM_001135647
FAM53C	hsa-miR-6825-5p	91.1231	NM_001135647
FAM53C	hsa-miR-5582-3p	90.5295	NM_001135647
FAM53C	hsa-miR-8485	88.5912	NM_001135647
FAM53C	hsa-miR-6866-5p	88.4066	NM_001135647
FAM53C	hsa-miR-4731-5p	88.4063	NM_001135647
FAM53C	hsa-miR-1827	87.4812	NM_001135647
FAM53C	hsa-miR-6799-3p	87.2486	NM_001135647
FAM53C	hsa-miR-3173-5p	87.2486	NM_001135647
FAM53C	hsa-miR-4489	87.0151	NM_001135647
FAM53C	hsa-miR-499b-5p	86.5015	NM_001135647
FAM53C	hsa-miR-1226-3p	86.4428	NM_001135647
FAM53C	hsa-miR-4283	86.0125	NM_001135647
FAM53C	hsa-miR-6071	85.5022	NM_001135647
FAM53C	hsa-miR-299-5p	85.479	NM_001135647
FAM53C	hsa-miR-3135b	84.8719	NM_001135647
FAM53C	hsa-miR-4691-3p	84.6899	NM_001135647
FAM53C	hsa-miR-450a-1-3p	84.3729	NM_001135647
FAM53C	hsa-miR-874-3p	84.1018	NM_001135647
FAM53C	hsa-miR-10527-5p	84.0895	NM_001135647
FAM53C	hsa-miR-3692-3p	82.8629	NM_001135647
FAM53C	hsa-miR-4672	81.9169	NM_001135647
FAM53C	hsa-miR-4668-5p	81.2812	NM_001135647
FAM53C	hsa-miR-892a	81.1341	NM_001135647
FAM53C	hsa-miR-939-3p	81.1074	NM_001135647
FAM53C	hsa-miR-1290	80.2817	NM_001135647

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Motifs and transcription factors (TFs) regulating FAM53C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM53C	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
FAM53C	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
FAM53C	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."