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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM43A

Summary for FAM43A

Gene information	Gene symbol	FAM43A
	Ensembl ID	ENSG00000185112
	Entrez ID	131583
	Gene name	family with sequence similarity 43 member A
	Synonyms	FLJ90022
	Gene type	protein_coding
	UniProtAcc	Q8N2R8

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Dataset with differentially expressed gene: FAM43A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.29005	6.37e-42
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.314468	1.43e-16
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.346478	1.03e-19
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.27607	1.12e-36

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Expression of FAM43A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM43A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM43A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM43A	hsa-miR-548f-5p	98.3792	NM_153690
FAM43A	hsa-miR-548x-5p	98.3792	NM_153690
FAM43A	hsa-miR-548aj-5p	98.3792	NM_153690
FAM43A	hsa-miR-548g-5p	98.3792	NM_153690
FAM43A	hsa-miR-19a-3p	97.1427	NM_153690
FAM43A	hsa-miR-19b-3p	97.1427	NM_153690
FAM43A	hsa-miR-545-3p	95.7828	NM_153690
FAM43A	hsa-miR-30d-5p	95.6893	NM_153690
FAM43A	hsa-miR-30a-5p	95.6893	NM_153690
FAM43A	hsa-miR-30c-5p	94.3875	NM_153690
FAM43A	hsa-miR-30e-5p	94.3875	NM_153690
FAM43A	hsa-miR-30b-5p	94.3875	NM_153690
FAM43A	hsa-miR-148b-3p	92.9589	NM_153690
FAM43A	hsa-miR-148a-3p	92.9589	NM_153690
FAM43A	hsa-miR-152-3p	92.9589	NM_153690
FAM43A	hsa-miR-2681-3p	89.3866	NM_153690
FAM43A	hsa-miR-507	89.0096	NM_153690
FAM43A	hsa-miR-7162-3p	88.9465	NM_153690
FAM43A	hsa-miR-182-5p	86.9969	NM_153690
FAM43A	hsa-miR-557	85.8143	NM_153690
FAM43A	hsa-miR-3120-3p	84.1781	NM_153690
FAM43A	hsa-miR-4789-5p	83.9524	NM_153690
FAM43A	hsa-miR-96-5p	83.3293	NM_153690
FAM43A	hsa-miR-3059-5p	82.697	NM_153690
FAM43A	hsa-let-7a-2-3p	81.8958	NM_153690
FAM43A	hsa-let-7g-3p	81.8958	NM_153690
FAM43A	hsa-miR-548aw	81.8155	NM_153690
FAM43A	hsa-miR-12133	80.8788	NM_153690
FAM43A	hsa-miR-1271-5p	80.8788	NM_153690
FAM43A	hsa-miR-6867-5p	80.516	NM_153690
FAM43A	hsa-miR-8055	80.3601	NM_153690
FAM43A	hsa-miR-12129	80.3242	NM_153690

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Motifs and transcription factors (TFs) regulating FAM43A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM43A	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
FAM43A	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
FAM43A	metacluster_187.7	FEZF1; FEZF1; ZNF384; ZNF384; ZNF384 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
FAM43A	metacluster_22.37	BACH1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."