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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM229B

Summary for FAM229B

Gene information	Gene symbol	FAM229B
	Ensembl ID	ENSG00000203778
	Entrez ID	619208
	Gene name	family with sequence similarity 229 member B
	Synonyms	C6orf225\|DKFZp586F0922\|LOC619208
	Gene type	protein_coding
	UniProtAcc	Q4G0N7

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Dataset with differentially expressed gene: FAM229B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.994895	1.34e-04
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.525897	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.420071	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.441851	1.89e-25
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.312159	0.00e+00

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Expression of FAM229B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM229B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM229B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM229B	hsa-miR-10397-5p	89.0573	NM_001033564
FAM229B	hsa-miR-6841-5p	85.815	NM_001033564
FAM229B	hsa-miR-5196-3p	84.8958	NM_001033564
FAM229B	hsa-miR-629-3p	84.266	NM_001033564
FAM229B	hsa-miR-30a-5p	82.6031	NM_001033564
FAM229B	hsa-miR-30e-5p	82.6031	NM_001033564
FAM229B	hsa-miR-30d-5p	82.6031	NM_001033564
FAM229B	hsa-miR-30c-5p	82.6031	NM_001033564
FAM229B	hsa-miR-30b-5p	82.6031	NM_001033564
FAM229B	hsa-miR-4778-5p	80.3321	NM_001033564

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Motifs and transcription factors (TFs) regulating FAM229B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM229B	jaspar__MA1933.1	SREBF2 (directAnnotation).
FAM229B	hdpi__ETV4	ETV4 (directAnnotation).
FAM229B	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
FAM229B	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
FAM229B	jaspar__MA1483.2	ELF2 (directAnnotation).
FAM229B	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
FAM229B	cisbp__M08198	ELF1 (directAnnotation).
FAM229B	metacluster_19.7	GMEB1; GMEB2 (inferredBy_Orthology).
FAM229B	transfac_pro__M04826	EP300 (directAnnotation).
FAM229B	transfac_pro__M05981	ZNF233 (directAnnotation).
FAM229B	dbtfbs__E4F1_K562_ENCSR731LHZ_merged_N1	E4F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."