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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM222B

Summary for FAM222B

Gene information	Gene symbol	FAM222B
	Ensembl ID	ENSG00000173065
	Entrez ID	55731
	Gene name	family with sequence similarity 222 member B
	Synonyms	C17orf63\|FLJ10700
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: FAM222B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.335501	9.47e-30

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Expression of FAM222B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM222B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM222B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM222B	hsa-miR-423-5p	98.5599	NM_001077498
FAM222B	hsa-miR-3184-5p	98.5599	NM_001077498
FAM222B	hsa-miR-6825-5p	97.6507	NM_001288640
FAM222B	hsa-miR-6085	96.5674	NM_001077498
FAM222B	hsa-miR-101-3p	96.4592	NM_001077498
FAM222B	hsa-miR-4534	96.3947	NM_001288640
FAM222B	hsa-miR-4441	94.8602	NM_001288640
FAM222B	hsa-miR-199a-5p	94.8226	NM_001077498
FAM222B	hsa-miR-6813-5p	94.6771	NM_001077498
FAM222B	hsa-miR-139-5p	94.6253	NM_001077498
FAM222B	hsa-miR-8082	94.4557	NM_001288640
FAM222B	hsa-miR-548v	94.2279	NM_001077498
FAM222B	hsa-miR-4270	93.7275	NM_001288640
FAM222B	hsa-miR-4306	92.7766	NM_001288640
FAM222B	hsa-miR-199b-5p	92.6634	NM_001077498
FAM222B	hsa-miR-95-5p	91.6331	NM_001077498
FAM222B	hsa-miR-6754-5p	91.4376	NM_001288640
FAM222B	hsa-miR-6804-5p	91.4003	NM_001288640
FAM222B	hsa-miR-4280	91.115	NM_001077498
FAM222B	hsa-miR-144-3p	90.7322	NM_001077498
FAM222B	hsa-miR-5581-3p	90.7257	NM_001077498
FAM222B	hsa-miR-29b-1-5p	90.2819	NM_001288640
FAM222B	hsa-miR-6077	89.609	NM_001288640
FAM222B	hsa-miR-6842-3p	89.5061	NM_001288640
FAM222B	hsa-miR-5582-3p	89.4196	NM_001288640
FAM222B	hsa-miR-374b-5p	88.9413	NM_001288640
FAM222B	hsa-miR-374a-5p	88.8676	NM_001288640
FAM222B	hsa-miR-4779	88.2836	NM_001288640
FAM222B	hsa-miR-4657	87.9524	NM_001288640
FAM222B	hsa-miR-4491	87.9524	NM_001288640
FAM222B	hsa-miR-4771	87.3011	NM_001288640
FAM222B	hsa-miR-4732-5p	86.2591	NM_001288640
FAM222B	hsa-miR-4789-3p	84.0867	NM_001288640
FAM222B	hsa-miR-3117-3p	83.9722	NM_001288640
FAM222B	hsa-miR-185-5p	83.3776	NM_001288640
FAM222B	hsa-miR-4644	83.3776	NM_001288640
FAM222B	hsa-miR-6794-5p	83.2701	NM_001288640
FAM222B	hsa-miR-548aa	83.021	NM_001288640
FAM222B	hsa-miR-548t-3p	83.021	NM_001288640
FAM222B	hsa-miR-548ap-3p	83.021	NM_001288640
FAM222B	hsa-miR-4716-3p	82.8461	NM_001288640
FAM222B	hsa-miR-3686	82.0687	NM_001288640
FAM222B	hsa-miR-5194	81.9548	NM_001077498
FAM222B	hsa-miR-539-3p	81.0452	NM_001077498
FAM222B	hsa-miR-485-3p	81.0452	NM_001077498
FAM222B	hsa-miR-4430	80.3951	NM_001288640
FAM222B	hsa-miR-3652	80.3951	NM_001288640
FAM222B	hsa-miR-7854-3p	80.0677	NM_001288640

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Motifs and transcription factors (TFs) regulating FAM222B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM222B	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
FAM222B	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
FAM222B	metacluster_160.20	JUND; PRDM15 (directAnnotation).
FAM222B	cisbp__M00341	PAX6 (directAnnotation).
FAM222B	metacluster_198.3	ZFP64 (directAnnotation).
FAM222B	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
FAM222B	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
FAM222B	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
FAM222B	metacluster_175.1	ZNF283 (directAnnotation).
FAM222B	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
FAM222B	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
FAM222B	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
FAM222B	metacluster_151.2	ZNF23 (directAnnotation).
FAM222B	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."