Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM219B

Summary for FAM219B

Gene information	Gene symbol	FAM219B
	Ensembl ID	ENSG00000178761
	Entrez ID	57184
	Gene name	family with sequence similarity 219 member B
	Synonyms	C15orf17\|FLJ00005
	Gene type	protein_coding
	UniProtAcc	Q5XKK7

Top

Dataset with differentially expressed gene: FAM219B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.277569	0.00e+00

Top

Expression of FAM219B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to FAM219B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating FAM219B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM219B	hsa-miR-339-5p	96.2789	NM_001321920
FAM219B	hsa-miR-20a-5p	93.6509	NM_001321922
FAM219B	hsa-miR-106b-5p	93.6509	NM_001321922
FAM219B	hsa-miR-3158-5p	93.3321	NM_001321920
FAM219B	hsa-miR-3692-5p	90.5491	NM_001321920
FAM219B	hsa-miR-106a-5p	90.4076	NM_001321922
FAM219B	hsa-miR-526b-3p	90.4076	NM_001321922
FAM219B	hsa-miR-20b-5p	90.2945	NM_001321922
FAM219B	hsa-miR-519d-3p	90.2945	NM_001321922
FAM219B	hsa-miR-17-5p	90.2945	NM_001321922
FAM219B	hsa-miR-93-5p	90.2945	NM_001321922
FAM219B	hsa-miR-133a-5p	89.6492	NM_001321920
FAM219B	hsa-miR-152-5p	86.7094	NM_001321920
FAM219B	hsa-miR-302e	84.5493	NM_001321922
FAM219B	hsa-miR-938	83.8829	NM_001321922
FAM219B	hsa-miR-6876-3p	83.322	NM_001321922
FAM219B	hsa-miR-6793-3p	82.9556	NM_001321920
FAM219B	hsa-miR-2276-5p	82.9231	NM_001321922
FAM219B	hsa-miR-302b-3p	81.371	NM_001321922
FAM219B	hsa-miR-302c-3p	81.371	NM_001321922
FAM219B	hsa-miR-302a-3p	81.371	NM_001321922
FAM219B	hsa-miR-302d-3p	81.371	NM_001321922
FAM219B	hsa-miR-3714	81.2666	NM_001321922
FAM219B	hsa-miR-626	80.8029	NM_001321922

Page: 1

Top

Motifs and transcription factors (TFs) regulating FAM219B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."