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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM217B

Summary for FAM217B

Gene information	Gene symbol	FAM217B
	Ensembl ID	ENSG00000196227
	Entrez ID	63939
	Gene name	family with sequence similarity 217 member B
	Synonyms	C20orf177\|dJ551D2.5
	Gene type	protein_coding
	UniProtAcc	Q9NTX9

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Dataset with differentially expressed gene: FAM217B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.311859	3.64e-19
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.318042	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.367267	0.00e+00

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Expression of FAM217B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM217B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM217B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM217B	hsa-miR-1184	94.1535	NM_001190826
FAM217B	hsa-miR-183-5p	93.1294	NM_001190826
FAM217B	hsa-miR-3140-3p	88.8565	NM_001190826
FAM217B	hsa-miR-1205	88.8045	NM_001190826
FAM217B	hsa-miR-10394-5p	88.8045	NM_001190826
FAM217B	hsa-miR-2355-5p	87.5448	NM_001190826
FAM217B	hsa-miR-616-5p	86.197	NM_001190826
FAM217B	hsa-miR-371b-5p	86.197	NM_001190826
FAM217B	hsa-miR-373-5p	86.197	NM_001190826
FAM217B	hsa-miR-4749-3p	85.3587	NM_001190826
FAM217B	hsa-miR-1237-3p	85.1414	NM_001190826
FAM217B	hsa-miR-218-5p	84.8301	NM_001190826
FAM217B	hsa-miR-4649-3p	83.6372	NM_001190826
FAM217B	hsa-miR-27a-3p	83.6277	NM_001190826
FAM217B	hsa-miR-27b-3p	83.6277	NM_001190826
FAM217B	hsa-miR-9985	83.6277	NM_001190826
FAM217B	hsa-miR-17-3p	83.2987	NM_001190826
FAM217B	hsa-miR-3919	82.4884	NM_001190826
FAM217B	hsa-miR-493-5p	82.3516	NM_001190826
FAM217B	hsa-miR-2276-3p	82.1468	NM_001190826
FAM217B	hsa-miR-3915	80.669	NM_001190826
FAM217B	hsa-miR-4793-3p	80.5495	NM_001190826
FAM217B	hsa-miR-4690-3p	80.0236	NM_001190826
FAM217B	hsa-miR-5685	80.0236	NM_001190826

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Motifs and transcription factors (TFs) regulating FAM217B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM217B	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
FAM217B	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
FAM217B	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
FAM217B	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
FAM217B	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
FAM217B	metacluster_3.14	WT1; WT1 (directAnnotation).
FAM217B	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
FAM217B	cisbp__M07938	E2F1 (directAnnotation).
FAM217B	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
FAM217B	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
FAM217B	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
FAM217B	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
FAM217B	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
FAM217B	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
FAM217B	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
FAM217B	hdpi__ETV4	ETV4 (directAnnotation).
FAM217B	jaspar__MA1122.1	TFDP1 (directAnnotation).
FAM217B	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
FAM217B	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
FAM217B	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
FAM217B	transfac_pro__M04826	EP300 (directAnnotation).
FAM217B	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
FAM217B	transfac_pro__M04862	NRF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."