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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM210B

Summary for FAM210B

Gene information	Gene symbol	FAM210B
	Ensembl ID	ENSG00000124098
	Entrez ID	116151
	Gene name	family with sequence similarity 210 member B
	Synonyms	C20orf108\|dJ1167H4.1\|DKFZP434A1114
	Gene type	protein_coding
	UniProtAcc	Q96KR6

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Dataset with differentially expressed gene: FAM210B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.26558	2.53e-21
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.44689	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.407224	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.476099	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.311133	3.16e-18
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.250846	6.63e-05
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.682776	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.337319	1.35e-12
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.444192	0.00e+00

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Expression of FAM210B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM210B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM210B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM210B	hsa-miR-32-3p	97.0473	NM_080821
FAM210B	hsa-miR-4760-5p	96.6715	NM_080821
FAM210B	hsa-miR-6766-3p	95.3265	NM_080821
FAM210B	hsa-miR-219a-5p	95.3265	NM_080821
FAM210B	hsa-miR-4782-3p	95.3265	NM_080821
FAM210B	hsa-miR-8061	94.7381	NM_080821
FAM210B	hsa-miR-30b-5p	93.0752	NM_080821
FAM210B	hsa-miR-30c-5p	93.0752	NM_080821
FAM210B	hsa-miR-30a-5p	93.0752	NM_080821
FAM210B	hsa-miR-30d-5p	93.0752	NM_080821
FAM210B	hsa-miR-30e-5p	93.0752	NM_080821
FAM210B	hsa-miR-548aa	90.6788	NM_080821
FAM210B	hsa-miR-548t-3p	90.6788	NM_080821
FAM210B	hsa-miR-548ap-3p	90.6788	NM_080821
FAM210B	hsa-miR-153-5p	90.4943	NM_080821
FAM210B	hsa-miR-3201	89.2812	NM_080821
FAM210B	hsa-miR-6128	88.5259	NM_080821
FAM210B	hsa-miR-4772-3p	88.11	NM_080821
FAM210B	hsa-miR-590-3p	88.103	NM_080821
FAM210B	hsa-miR-6886-3p	86.6733	NM_080821
FAM210B	hsa-miR-6516-3p	85.6664	NM_080821
FAM210B	hsa-miR-4791	85.2714	NM_080821
FAM210B	hsa-miR-4531	85.0317	NM_080821
FAM210B	hsa-miR-938	84.5377	NM_080821
FAM210B	hsa-miR-3658	83.9476	NM_080821
FAM210B	hsa-miR-628-5p	83.0842	NM_080821
FAM210B	hsa-miR-9718	82.9549	NM_080821
FAM210B	hsa-miR-9983-3p	81.068	NM_080821
FAM210B	hsa-miR-138-5p	80.9128	NM_080821
FAM210B	hsa-miR-12115	80.7541	NM_080821
FAM210B	hsa-miR-4474-3p	80.5566	NM_080821
FAM210B	hsa-miR-9851-5p	80.4799	NM_080821

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Motifs and transcription factors (TFs) regulating FAM210B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM210B	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
FAM210B	metacluster_151.2	ZNF23 (directAnnotation).
FAM210B	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
FAM210B	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
FAM210B	transfac_pro__M05628	ZNF735 (directAnnotation).
FAM210B	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
FAM210B	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
FAM210B	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
FAM210B	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
FAM210B	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
FAM210B	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
FAM210B	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
FAM210B	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
FAM210B	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
FAM210B	transfac_pro__M02090	E2F4 (directAnnotation).
FAM210B	transfac_pro__M02089	E2F3 (directAnnotation).
FAM210B	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
FAM210B	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
FAM210B	cisbp__M07938	E2F1 (directAnnotation).
FAM210B	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
FAM210B	transfac_pro__M02898	SMAD3 (directAnnotation).
FAM210B	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
FAM210B	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
FAM210B	transfac_pro__M04866	HDAC2 (directAnnotation).
FAM210B	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
FAM210B	dbtfbs__ZNF121_HEK293_ENCSR224QDY_merged_N3	ZNF121 (directAnnotation).
FAM210B	transfac_pro__M06331	ZNF343 (directAnnotation).
FAM210B	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
FAM210B	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
FAM210B	jaspar__MA0079.5	SP1 (directAnnotation).
FAM210B	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
FAM210B	transfac_pro__M01253	CNOT3 (directAnnotation).
FAM210B	transfac_pro__M07270	TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."