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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM174B

Summary for FAM174B

Gene information	Gene symbol	FAM174B
	Ensembl ID	ENSG00000185442
	Entrez ID	400451
	Gene name	family with sequence similarity 174 member B
	Synonyms	LOC400451\|MGC102891
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: FAM174B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.346875	0.00e+00

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Expression of FAM174B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM174B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM174B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM174B	hsa-miR-615-5p	92.5292	NM_207446
FAM174B	hsa-miR-4470	91.4715	NM_207446
FAM174B	hsa-miR-505-3p	90.278	NM_207446
FAM174B	hsa-miR-5698	89.8112	NM_207446
FAM174B	hsa-miR-4723-5p	89.8112	NM_207446
FAM174B	hsa-miR-6870-5p	89.8112	NM_207446
FAM174B	hsa-miR-7111-5p	89.8112	NM_207446
FAM174B	hsa-miR-8485	83.032	NM_207446
FAM174B	hsa-miR-519b-5p	82.5442	NM_207446
FAM174B	hsa-miR-520c-5p	82.5442	NM_207446
FAM174B	hsa-miR-518e-5p	82.5442	NM_207446
FAM174B	hsa-miR-518d-5p	82.5442	NM_207446
FAM174B	hsa-miR-518f-5p	82.5442	NM_207446
FAM174B	hsa-miR-522-5p	82.5442	NM_207446
FAM174B	hsa-miR-526a-5p	82.5442	NM_207446
FAM174B	hsa-miR-519c-5p	82.5442	NM_207446
FAM174B	hsa-miR-523-5p	82.5442	NM_207446
FAM174B	hsa-miR-519a-5p	82.5442	NM_207446
FAM174B	hsa-miR-5195-3p	80.0792	NM_207446
FAM174B	hsa-miR-145-5p	80.0792	NM_207446

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Motifs and transcription factors (TFs) regulating FAM174B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM174B	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
FAM174B	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
FAM174B	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
FAM174B	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."