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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM168A

Summary for FAM168A

Gene information	Gene symbol	FAM168A
	Ensembl ID	ENSG00000054965
	Entrez ID	23201
	Gene name	family with sequence similarity 168 member A
	Synonyms	KIAA0280\|TCRP1
	Gene type	protein_coding
	UniProtAcc	Q92567

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Dataset with differentially expressed gene: FAM168A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.973051	3.90e-02

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Expression of FAM168A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM168A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
FAM168A	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating FAM168A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM168A	hsa-miR-4795-3p	100	NM_001286050
FAM168A	hsa-miR-126-5p	100	NM_001286050
FAM168A	hsa-miR-548ap-3p	99.4284	NM_001286050
FAM168A	hsa-miR-548aa	99.4284	NM_001286050
FAM168A	hsa-miR-548t-3p	99.4284	NM_001286050
FAM168A	hsa-miR-9500	98.0974	NM_001286050
FAM168A	hsa-miR-3662	97.7298	NM_001286050
FAM168A	hsa-miR-1266-5p	97	NM_001286050
FAM168A	hsa-miR-4518	97	NM_001286050
FAM168A	hsa-miR-206	95.5293	NM_001286050
FAM168A	hsa-miR-1-3p	95.5293	NM_001286050
FAM168A	hsa-miR-6515-3p	95.4322	NM_001286050
FAM168A	hsa-miR-4267	94.561	NM_001286050
FAM168A	hsa-miR-5689	94.2116	NM_001286050
FAM168A	hsa-miR-330-5p	94.0966	NM_001286050
FAM168A	hsa-miR-182-5p	94.03	NM_001286050
FAM168A	hsa-miR-508-5p	93.9644	NM_001286050
FAM168A	hsa-miR-548aw	93.8099	NM_001286050
FAM168A	hsa-miR-613	93.692	NM_001286050
FAM168A	hsa-miR-326	93.6355	NM_001286050
FAM168A	hsa-miR-1323	93.227	NM_001286050
FAM168A	hsa-miR-6072	93.1904	NM_001286050
FAM168A	hsa-miR-6876-5p	93.0972	NM_001286050
FAM168A	hsa-miR-4476	93.0972	NM_001286050
FAM168A	hsa-miR-597-3p	92.6222	NM_001286050
FAM168A	hsa-miR-6735-3p	92.3115	NM_001286050
FAM168A	hsa-miR-670-3p	91.9558	NM_001286050
FAM168A	hsa-miR-6852-5p	91.6686	NM_001286050
FAM168A	hsa-miR-3175	91.5527	NM_001286050
FAM168A	hsa-miR-376a-2-5p	91.4221	NM_001286050
FAM168A	hsa-miR-4784	91.1784	NM_001286050
FAM168A	hsa-miR-548o-3p	91.1541	NM_001286050
FAM168A	hsa-miR-137-3p	90.7564	NM_001286050
FAM168A	hsa-miR-6891-3p	90.7175	NM_001286050
FAM168A	hsa-miR-4689	90.5018	NM_001286050
FAM168A	hsa-miR-6858-5p	90.4744	NM_001286050
FAM168A	hsa-miR-518a-5p	90.3871	NM_001286050
FAM168A	hsa-miR-527	90.3871	NM_001286050
FAM168A	hsa-miR-6884-5p	90.3836	NM_001286050
FAM168A	hsa-miR-485-5p	90.3836	NM_001286050
FAM168A	hsa-miR-3163	90.1758	NM_001286050
FAM168A	hsa-miR-4325	90.0557	NM_001286050
FAM168A	hsa-miR-548ah-5p	90.0471	NM_001286050
FAM168A	hsa-miR-3609	90.0471	NM_001286050
FAM168A	hsa-miR-7973	89.58	NM_001286050
FAM168A	hsa-miR-4768-3p	89.4758	NM_001286050
FAM168A	hsa-miR-6728-3p	89.4684	NM_001286050
FAM168A	hsa-miR-6731-5p	89.4184	NM_001286050
FAM168A	hsa-miR-8085	89.4184	NM_001286050
FAM168A	hsa-miR-7-5p	89.2281	NM_001286050

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Motifs and transcription factors (TFs) regulating FAM168A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM168A	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
FAM168A	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
FAM168A	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
FAM168A	transfac_pro__M04617	ZBTB7A (directAnnotation).
FAM168A	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
FAM168A	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
FAM168A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
FAM168A	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
FAM168A	transfac_pro__M07387	ZBTB7A (directAnnotation).
FAM168A	transfac_pro__M07436	WT1 (directAnnotation).
FAM168A	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
FAM168A	transfac_pro__M00716	ZBTB14 (directAnnotation).
FAM168A	swissregulon__hs__CHD1	CHD1 (directAnnotation).
FAM168A	hdpi__HIP2	UBE2K (directAnnotation).
FAM168A	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
FAM168A	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
FAM168A	transfac_pro__M04893	TAF1 (directAnnotation).
FAM168A	transfac_pro__M03876	ZBTB33 (directAnnotation).
FAM168A	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
FAM168A	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
FAM168A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
FAM168A	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."