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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM13A

Summary for FAM13A

Gene information	Gene symbol	FAM13A
	Ensembl ID	ENSG00000138640
	Entrez ID	10144
	Gene name	family with sequence similarity 13 member A
	Synonyms	ARHGAP48\|FAM13A1\|KIAA0914
	Gene type	protein_coding
	UniProtAcc	O94988

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Dataset with differentially expressed gene: FAM13A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.494561	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.304693	2.23e-06

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Expression of FAM13A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM13A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM13A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM13A	hsa-miR-10522-5p	96.6106	NM_001015045
FAM13A	hsa-miR-4786-3p	94.5093	NM_001015045
FAM13A	hsa-miR-21-5p	94.1246	NM_001015045
FAM13A	hsa-miR-590-5p	92.8088	NM_001015045
FAM13A	hsa-miR-4450	90.6769	NM_001265580
FAM13A	hsa-miR-20a-5p	88.7162	NM_001015045
FAM13A	hsa-miR-106b-5p	88.7162	NM_001015045
FAM13A	hsa-miR-7113-5p	88.4541	NM_001015045
FAM13A	hsa-miR-607	88.3159	NM_001015045
FAM13A	hsa-miR-6867-5p	87.8848	NM_001265580
FAM13A	hsa-miR-302a-5p	87.6934	NM_001265580
FAM13A	hsa-miR-526b-3p	87.2717	NM_001015045
FAM13A	hsa-miR-3920	87.0888	NM_001265580
FAM13A	hsa-miR-106a-5p	86.8079	NM_001015045
FAM13A	hsa-miR-93-5p	86.8079	NM_001015045
FAM13A	hsa-miR-17-5p	86.8079	NM_001015045
FAM13A	hsa-miR-519d-3p	86.8079	NM_001015045
FAM13A	hsa-miR-20b-5p	86.8079	NM_001015045
FAM13A	hsa-miR-3661	85.1664	NM_001265580
FAM13A	hsa-miR-4721	84.5672	NM_001015045
FAM13A	hsa-miR-4729	83.4346	NM_001265580
FAM13A	hsa-miR-6073	82.9309	NM_001015045
FAM13A	hsa-miR-4446-3p	82.6673	NM_001015045
FAM13A	hsa-miR-30a-5p	82.0894	NM_001015045
FAM13A	hsa-miR-30b-5p	82.0894	NM_001015045
FAM13A	hsa-miR-30e-5p	82.0894	NM_001015045
FAM13A	hsa-miR-30d-5p	82.0894	NM_001015045
FAM13A	hsa-miR-30c-5p	82.0894	NM_001015045
FAM13A	hsa-miR-3191-5p	81.9691	NM_001015045
FAM13A	hsa-miR-4261	81.9046	NM_001265580
FAM13A	hsa-miR-631	81.5776	NM_001265580
FAM13A	hsa-miR-3156-5p	80.9697	NM_001265580
FAM13A	hsa-miR-605-5p	80.5188	NM_001265580
FAM13A	hsa-miR-1257	80.1386	NM_001265580

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Motifs and transcription factors (TFs) regulating FAM13A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM13A	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
FAM13A	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."