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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FAM133A

Summary for FAM133A

Gene information	Gene symbol	FAM133A
	Ensembl ID	ENSG00000179083
	Entrez ID	286499
	Gene name	family with sequence similarity 133 member A
	Synonyms	CT115\|FLJ37659\|RP1-32F7.2
	Gene type	protein_coding
	UniProtAcc	Q8N9E0

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Dataset with differentially expressed gene: FAM133A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.590263	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.299313	4.22e-32
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.861245	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.351358	3.81e-30

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Expression of FAM133A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FAM133A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FAM133A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FAM133A	hsa-miR-30c-5p	91.6997	NM_001171109
FAM133A	hsa-miR-30d-5p	91.6997	NM_001171109
FAM133A	hsa-miR-30e-5p	91.6997	NM_001171109
FAM133A	hsa-miR-30a-5p	91.6997	NM_001171109
FAM133A	hsa-miR-30b-5p	91.6997	NM_001171109
FAM133A	hsa-miR-664a-3p	90.1943	NM_173698
FAM133A	hsa-miR-513a-3p	89.5402	NM_173698
FAM133A	hsa-miR-513c-3p	89.5402	NM_173698
FAM133A	hsa-miR-559	88.8121	NM_173698
FAM133A	hsa-miR-3606-3p	88.6028	NM_173698
FAM133A	hsa-miR-590-3p	87.61	NM_001171109
FAM133A	hsa-miR-607	87.0227	NM_001171109
FAM133A	hsa-miR-548a-5p	86.9825	NM_173698
FAM133A	hsa-miR-548ae-5p	86.9825	NM_173698
FAM133A	hsa-miR-548ar-5p	86.9825	NM_173698
FAM133A	hsa-miR-548w	86.9825	NM_173698
FAM133A	hsa-miR-548j-5p	86.9825	NM_173698
FAM133A	hsa-miR-548i	86.9825	NM_173698
FAM133A	hsa-miR-548as-5p	86.9825	NM_173698
FAM133A	hsa-miR-548d-5p	86.9825	NM_173698
FAM133A	hsa-miR-548ay-5p	86.9825	NM_173698
FAM133A	hsa-miR-548b-5p	86.9825	NM_173698
FAM133A	hsa-miR-548ad-5p	86.9825	NM_173698
FAM133A	hsa-miR-548y	86.9825	NM_173698
FAM133A	hsa-miR-548ak	86.9825	NM_173698
FAM133A	hsa-miR-548ap-5p	86.9825	NM_173698
FAM133A	hsa-miR-548bb-5p	86.9825	NM_173698
FAM133A	hsa-miR-548o-5p	86.9825	NM_173698
FAM133A	hsa-miR-548h-5p	86.9825	NM_173698
FAM133A	hsa-miR-548am-5p	86.9825	NM_173698
FAM133A	hsa-miR-548aq-5p	86.9825	NM_173698
FAM133A	hsa-miR-548au-5p	86.9825	NM_173698
FAM133A	hsa-miR-548c-5p	86.9825	NM_173698
FAM133A	hsa-miR-548ab	86.9825	NM_173698
FAM133A	hsa-miR-548at-5p	86.3187	NM_001171109
FAM133A	hsa-miR-3128	84.4841	NM_001171109
FAM133A	hsa-miR-6516-3p	83.5415	NM_173698
FAM133A	hsa-miR-6847-5p	82.6846	NM_173698
FAM133A	hsa-miR-5688	82.3823	NM_173698
FAM133A	hsa-miR-495-3p	82.3823	NM_173698
FAM133A	hsa-miR-2054	81.1328	NM_173698
FAM133A	hsa-miR-4686	80.7527	NM_173698
FAM133A	hsa-miR-653-3p	80.614	NM_173698
FAM133A	hsa-miR-205-3p	80.0225	NM_001171109

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Motifs and transcription factors (TFs) regulating FAM133A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FAM133A	taipale_cyt_meth__ELF3_NTGTGCGGATGCN_FL_repr	ELF3 (directAnnotation).
FAM133A	taipale_tf_pairs__ERF_DLX3_RSCGGAANNNNYAATTA_CAP_repr	DLX3; ERF (directAnnotation).
FAM133A	jaspar__MA0776.1	MYBL1 (directAnnotation).
FAM133A	kznf__ZNF653_Najafabadi2015_ChIP-seq	ZNF653 (directAnnotation).
FAM133A	jaspar__MA1957.1	ELK1 (directAnnotation).
FAM133A	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
FAM133A	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
FAM133A	c2h2_zfs__M0401	ZNF410 (inferredBy_Orthology).
FAM133A	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
FAM133A	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
FAM133A	metacluster_151.2	ZNF23 (directAnnotation).
FAM133A	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."